Aflapin®: A novel and selective 5-lipoxygenase inhibitor for arthritis management
Indian Journal of Pain, 2018 Osteoarthritis (OA) is the most common form of arthritis characterized by progressive destruction of joint cartilage tissue, pain and inflammation, stiffness, and impaired physical activity.
Manoj A Suva +2 more
doaj +1 more source
Modulation of the lipid mediator class switch in inflammation by phytomedical natural products [PDF]
, 2022 Professionelle Zellen des angeborenen Immunsystems kontrollieren die Entstehung, Erhaltung und Auflösung von Entzündungsreaktionen. Eine entscheidende Rolle spielen dabei durch Lipoxygenasen (LOX) und Cyclooxygenasen gebildete Lipidmediatoren, die sowohl
Börner, Friedemann
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Survey on the Quality of the Top-Selling European and American Botanical Dietary Supplements Containing Boswellic Acids [PDF]
, 2016 n/
Abdel-Tawab, Mona +5 more
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Veterinary Medicine and Science, Volume 12, Issue 3, May 2026.YSK‐AB, a botanical mixture, reduced nitric oxide production in RAW 264.7 cells and chemokine expression in canine keratinocytes, suggesting its potential as a natural therapeutic agent for inflammatory skin diseases in dogs. ABSTRACT Background Botanical ingredients can function as adjunctive therapies for managing inflammatory skin diseases ...
Danbee Ha +3 more
wiley +1 more source
An association of boswellia, betaine and myo-inositol (Eumastós) in the treatment of mammographic breast density. A randomized, double-blind study [PDF]
, 2015 Mammographic breast density is a recognized risk factor for breast cancer. The causes that lead to the proliferation of the glandular breast tissue and, therefore, to an increase of breast density are still unclear.
Alwasel, S. H +7 more
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Real world evidence of effectiveness and safety of an oral formulation containing un-denatured type-II collagen 40 mg and aflapin 100 mg (HAPID®) in the management of osteoarthritis of knee: findings of a prospective, multi-center, observational study [PDF]
, 2022 Background: Osteoarthritis (OA) of knee is a common progressive multifactorial joint disorder affecting the quality of life, and surgical repair is the final option which has substantial impact on healthcare costs.
., Shivarajaiah +18 more
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Advanced Science, Volume 13, Issue 21, 13 April 2026.RvD5 effectively alleviates UC by inhibiting STAT1 signaling to reduce CXCL8 expression in colonic epithelial cells via activation of GPR101, which subsequently decreases the infiltration of neutrophils in the colonic mucosal epithelium. Epimedin A1, a natural allosteric inhibitor of 5‐LOX, demonstrates potential as a therapeutic agent for UC by ...
Pengxiang Guo +9 more
wiley +1 more source
Pharmacological Activities of Boswellia serrata Roxb. - Mini Review [PDF]
, 2009 Boswellia serrata (Salai Guggal) is one of the most ancient and respected herbs in Ayurveda. “Gajabhakshya” a Sanskrit name sometimes used for Boswellia suggests that elephants enjoy this herb as a part of their diet.
Ghule, Balu, Upaganlawar, Aman
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Molecular Informatics, Volume 45, Issue 3, March 2026.Starting from incomplete structural information of 5‐lipoxygenase (5‐LOX), a multistep computational pipeline in silico led to powerful tools for the rational design and identification of novel chelator inhibitors. A reconstruction of the first full‐length 5‐LOX was performed and used to apply docking studies to enable to create a pharmacophore model ...
Lisa Lombardo +3 more
wiley +1 more source
Complementary medicine treatment options for children with diffuse intrinsic pontine gliomas [PDF]
Diffuse intrinsic pontine glioma is a rare but lethal brain tumor with a median survival of eleven months after diagnosis. There has been no significant improvement in survival over the past 50 and more years despite intensive research.
Pohlmeier, Bente
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