Results 91 to 100 of about 343,956 (260)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

On fuzzy quasi-prime ideals in near left almost rings [PDF]

open access: yes, 2019
In this investigation we studied fuzzy quasi-prime, weakly fuzzy quasi-prime, fuzzy completely prime and weakly fuzzy completely prime ideals in nLA-rings.
Pairote Yiarayong
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Semigroup ideal in Prime Near-Rings with Derivations [PDF]

open access: yes, 2011
In this paper we generalize some of the results due to Bell and Mason on a near-ring N admitting a derivation D , and we will show that the body of evidence on prime near-rings with derivations have the behavior of the ring.
Ahmed, Hiba A., Majeed, Abdullrahman H.
core   +2 more sources

Translating whole‐genome doubling into precision medicine in cancer

open access: yesMolecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Weakly Prime Ideals in Near-Rings [PDF]

open access: yes, 2016
[[abstract]]In this short note, we introduce the notion of prime ideals in nearring and obtain equivalent conditions for an ideal to be a weakly prime ...
P. Dheena, B. Elavarasan
core  

PANoptosis in the pathogenesis of myelodysplastic syndromes

open access: yesMolecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla   +4 more
wiley   +1 more source

Prime Ideals And Bi - Ideals In Gamma Near - Rings [PDF]

open access: yes, 2013
Throughout this paper we introduce the concept of prime ideals, maximalideals and bi - ideals in - near - rings obtaining some characterizations and theirlinks.
Eduard Domi; Department of Mathematics,University "A.Xhuvani"
core  

Characterization of 3-prime near-rings via multiplicative derivations

open access: yesAlgebra and Discrete Mathematics
Summary: In this paper, we will prove some theorems concerning the commutativity of 3-prime near-rings which satisfy some differential identities on semigroup ideals and Jordan ideals of a near-ring \(\mathcal{N}\) admitting a multiplicative derivation.
El Amrani, Slimane   +2 more
openaire   +2 more sources

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