Results 171 to 180 of about 8,097,373 (363)

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

open access: yesMolecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka   +10 more
wiley   +1 more source

The behaviour and health of dairy lambs reared artificially with and without early access to meal : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Animal Science at Massey University. [PDF]

open access: yes, 2017
Many large-scale dairy sheep producers use lamb-rearing systems and provide lambs with milk replacer (MR) ad libitum and grain-based meal to accelerate rumen development to support early weaning methods.
Nieper, Bradley Allan
core  

Perpetuating global inequalities in the knowledge economy: The case of HIV social science research in East Africa

open access: yesGlobal Public Health
Despite almost a century’s research capacity strengthening in Africa, HIV/AIDS research has been dominated by high-income countries (HICs), illustrating broader inequalities in the global knowledge economy.
Daniel Wight
doaj   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

open access: yesMolecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Achieving equitable access to health technologies during a pandemic: Lessons learned from UK universities’ technology transfer practices & policies 2019–2023

open access: yesGlobal Public Health
The COVID-19 pandemic underlined stark inequalities in timely access to health technologies worldwide. Universities, by conducting a significant amount of early biomedical research and development, have a critical but often overlooked role in determining
Ayolola Eni-Olotu   +4 more
doaj   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

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