Results 171 to 180 of about 8,269,734 (342)

Application of Underwater Photo Transect Method to Understand Coral Reefs Cover in Pombo Island, Maluku [PDF]

open access: yes, 2016
Methods to understand coral reefs health are increasingly diverse. One of the promising method is georeferenced photo transect. In this method, a diver took benthic community photos using a camera installed or connected with a Global Positioning System ...
Adji, A. S. (Arif)   +2 more
core  

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

open access: yesFEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello   +6 more
wiley   +1 more source

Handling the dry-off problem in organic dairy herds by teat sealing or homeopathy com-pared to therapy omission [PDF]

open access: yes, 2006
Avoiding antibiotics is one of the crucial goals in organic dairy herd health management. Thus, a trial with 102 cows (408 quarters) was conducted to com-pare 2 common medical dry-off practices in organic dairying, internal teat sealant (Orbeseal ...
Heil, Fritz   +4 more
core  

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

open access: yesMolecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

SDG 3: Good Health and Well-Being – Framing Targets to Maximise Co-Benefits for Forests and People

open access: green, 2019
R. A. McFarlane   +10 more
openalex   +2 more sources

Social Capital and Health of Older Europeans [PDF]

open access: yes
This research uses a time-based approach of the causal relationship (Granger-like)between health and social capital for older people in Europe. We use panel data from waves 1 and 2 of SHARE (the Survey of Health, Ageing, and Retirement in Europe)for the ...
Nicolas Sirven, Thierry Debrand
core  

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

open access: yesMolecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser   +11 more
wiley   +1 more source

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