Results 161 to 170 of about 9,962,525 (239)

Identification and Biological Evaluation of Fisetin as a Novel DYRK1B Inhibitor in Ovarian Cancer with Apoptotic and Ferroptotic Effects. [PDF]

Drug Des Devel Ther
Sam A, Peng CH, Hsu KC, HuangFu WC.
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

An Inverse-Selection-Probability Weighted Approach for Real-World Progression-Free Survival With Left-Truncated Clinico-Genomic Data. [PDF]

Pharm Stat
Liu Y, Hyun SW, Sangli C, Beauchamp K, Islam F, Shin D.   +5 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

30 Years of Methods

BioTechniques, 2013
openaire   +3 more sources

Three-Dimensional Computed Tomography-Based Mapping of the Intraosseous Safe Zone for Acetabular Cup Screw Fixation: A Retrospective, Single-Center Cohort Study. [PDF]

JB JS Open Access
Sato T, Hirasawa R, Hagiwara S, Kaneko H, Hamano H, Kawarai Y, Nakamura J, Ohtori S.   +7 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Does Hospital Accreditation Increase Inpatient Expenditure and Improve Quality of Care? Evidence from Heart Failure Admissions in County-Level Public Hospitals in China. [PDF]

Risk Manag Healthc Policy
Tan H, Fang H.
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source