Results 151 to 160 of about 9,649,671 (339)

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

open access: yesFEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan   +6 more
wiley   +1 more source

Towards a More Democratic Regime and Society? The Politics of Faith and Ethnicity in a Transitional Multi-Ethnic Malaysia

open access: yesJournal of Current Southeast Asian Affairs, 2013
The rising antagonistic attitudes and tension between the Malay majority and ethnic and religious minorities in Malaysia since 2007 is intriguing because it has occurred when society experienced an unprecedentedly large-scale and assertive multi-ethnic ...
Kikue Hamayotsu
doaj  

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

open access: yesFEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani   +7 more
wiley   +1 more source

Malapportionment and Geographical Bases of Electoral Support in the Brazilian Senate Desproporcionalidade de Representação e Geografia de Bases Eleitorais no Senado Brasileiro

open access: yesJournal of Politics in Latin America, 2013
This paper analyzes the relationship between malapportionment and electoral bases of support for Brazilian senators. The conventional wisdom asserts that malapportionment contributes to the “politics of backwardness” – that it facilitates clientelism and
Taeko Hiroi, Pedro Neiva
doaj  

Effects of high energy radiation on the mechanical properties of epoxy/graphite fiber reinforced composites [PDF]

open access: yes
Publications and theses generated on composite research are listed. Surface energy changes of an epoxy based on tetraglycidyl diaminodiphenyl methane (TGDDM)/diaminodiphenyl sulfone (DDS), T-300 graphite fiber and T-300/5208 (graphite fiber/epoxy ...
Fornes, R. E.   +2 more
core   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

open access: yesFEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Book Review: Heiduk, Felix (ed.): Security Sector Reform in Southeast Asia: From Policy to Practice

open access: yesJournal of Current Southeast Asian Affairs, 2015
Book Review of the edited volume by Heiduk, Felix (ed.) (2014), Security Sector Reform in Southeast Asia: From Policy to Practice. Basingstoke, Hampshire: Palgrave MacMillan, ISBN 978-0-230-22 896-2, 264 pages.
Leanne-Marie McCarthy-Cotter
doaj  

The Role of the Structural Transformation in Aggregate Productivity [PDF]

open access: yes
We investigate the role of sectoral differences in labor productivity and the process of structural transformation (the secular reallocation of labor across sectors) in accounting for the time path of aggregate productivity across countries.
Diego Restuccia, Margarida Duarte
core  

Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe

open access: yesFEBS Open Bio, EarlyView.
Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley   +1 more source

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