Results 61 to 70 of about 30,542 (196)

Cardiorespiratory fitness and type 2 diabetes risk: A prospective cohort study with mediation analysis of biological aging in the UK Biobank

Diabetes, Obesity and Metabolism, Volume 28, Issue 2, Page 914-924, February 2026.
Abstract Aims Higher cardiorespiratory fitness is associated with reduced type 2 diabetes mellitus (T2D) risk, but the underlying mechanisms remain incompletely understood. We investigated whether biological aging mediates the association between maximal oxygen uptake (VO2max) and incident T2D risk.
Xiangliang Liu, Xinqiao Chen, Wang Yang, Guanran Ding, Yixin Zhao, Yuguang Li, Naifei Chen, Jiuwei Cui   +7 more
wiley   +1 more source

Managing Newborn Screening Repeat Collections for Sick and Preterm Neonates

International Journal of Neonatal Screening
Some preterm and sick neonates have altered biochemical profiles and follow-up newborn screening (NBS) collections are recommended. The Victorian NBS program historically recommended repeat collections for babies with birth weight < 1500 g (managed by ...
Ronda F. Greaves, Jo-Ann Northfield, Lauren Cross, Nazha Mawad, Thanh Nguyen, Maggie Tan, Michele A. O’Connell, James Pitt   +7 more
doaj   +1 more source

Severe Impairment of TNF Post-transcriptional Regulation Leads to Embryonic Death

iScience, 2020
Summary: Post-transcriptional regulation mechanisms control mRNA stability or translational efficiency via ribosomes, and recent evidence indicates that it is a major determinant of the accurate levels of cytokine mRNAs. Transcriptional regulation of Tnf
Elise Clayer, Destiny Dalseno, Andrew Kueh, Derek Lacey, Minhsuang Tsai, Elysa Carr, Verena C. Wimmer, Philippe Bouillet   +7 more
doaj   +1 more source

The Massive Binary Pulsar J1740-3052

, 2002
The young pulsar J1740-3052 is in an 8-month orbit with a companion of at least 11 solar masses. We present multifrequency GBT and Parkes timing observations, and discuss implications for the nature of the companion.
Stairs, I. H., Manchester, R. N., Lyne, A. G., Kramer, M., Kaspi, V. M., Camilo, F., D'Amico, N.   +6 more
openaire   +2 more sources

Sodium glucose co‐transporter 2 inhibitors versus dipeptidyl peptidase‐4 inhibitors and the risk of ventricular arrhythmia among patients with type 2 diabetes: A population‐based cohort study

Diabetes, Obesity and Metabolism, Volume 28, Issue 2, Page 935-945, February 2026.
Abstract Aims To determine whether sodium glucose co‐transporter 2 inhibitors (SGLT2i) use, compared with dipeptidyl peptidase‐4 inhibitors (DPP4i) use, is associated with the risk of ventricular arrhythmias (VA) among patients with type 2 diabetes. Materials and Methods We conducted a population‐based cohort study using a prevalent new‐user design and
Wang‐Choi Tang, Pauline Reynier, Antonios Douros, Oriana H. Y. Yu, Robert W. Platt, Kristian B. Filion   +5 more
wiley   +1 more source

An Inducible Lentiviral Guide RNA Platform Enables the Identification of Tumor-Essential Genes and Tumor-Promoting Mutations In Vivo

Cell Reports, 2015
The CRISPR/Cas9 technology enables the introduction of genomic alterations into almost any organism; however, systems for efficient and inducible gene modification have been lacking, especially for deletion of essential genes.
Brandon J. Aubrey, Gemma L. Kelly, Andrew J. Kueh, Margs S. Brennan, Liam O’Connor, Liz Milla, Stephen Wilcox, Lin Tai, Andreas Strasser, Marco J. Herold   +9 more
doaj   +1 more source

#3052 mTOR inhibitors in kidney transplant recipients with high immunological risk: practical insights from clinical experience

Nephrology, Dialysis and Transplantation
The use of mTOR inhibitors (mTORi) is not usually considered in high immunological risk kidney transplant recipients (KTR) for a perceived increased risk of rejection.
Judit Cacho, Matthias Cassia, Veronica Torres, Hugo Vergara Pérez, Ángela González, Diana Rodríguez, Enrique Montagud‐Marrahi, Elena Cuadrado, Fritz Diekmann, D. Cucchiari   +9 more
semanticscholar   +1 more source

Cyclic Peptide–Polymer Conjugate Nanotubes for Delivery of SN‐38 in Treatment of Colorectal Cancer Model

Advanced Healthcare Materials, Volume 15, Issue 4, 26 January 2026.
This study develops cyclic peptidepolymer conjugate nanotubes with hydrophobic, drug‐rich cores to enhance drug loading and stability, and demonstrates their responsive disassembly, pharmacokinetics, and anti‐tumour efficacy in colorectal cancer models using the anticancer drug SN‐38.
Sophie K. Hill, Min Zeng, Santhosh Kalash Rajendrakumar, Robert Dallmann, Sébastien Perrier   +4 more
wiley   +1 more source

Polyphenol‐Mediated Engineering of Lipid Nanoparticles With Crystalline Mesophases

Advanced Materials, Volume 38, Issue 6, 27 January 2026.
A polyphenol‐mediated strategy enables the one‐step formation of lipid nanoparticles with nonlamellar mesophases, including micellar cubic and hexagonal structures. These highly ordered nanostructures accommodate a wide range of cargos—from metal ions to mRNA—and offer a modular and versatile platform for constructing functional lipid‐based delivery ...
Shiyao Li, Patrick Charchar, Haitao Yu, Zhixing Lin, Hamish G. Brown, Wanjun Xu, Chan‐Jin Kim, Irene Yarovsky, Yi Ju, Frank Caruso   +9 more
wiley   +1 more source

Evaluating the “right@home” randomised trial of nurse home visiting using linked administrative data at school transition

International Journal of Population Data Science
Introduction Nurse home visiting (NHV) is designed to redress child and maternal health inequities, but long-term evaluation is hampered by sample attrition.
Anna Price, Jiaxin Zhang, Sharon Goldfeld, John Carlin, Fiona Mensah   +4 more
doaj   +1 more source