Results 41 to 50 of about 3,078,220 (286)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Axial Spondyloarthritis in the Era of Precision Medicine: Biomarkers, Microbiota, and Multimodal Therapy

Quality in Sport
Introduction and Purpose Axial spondyloarthritis (axSpA) is a chronic inflammatory rheumatic disease affecting the axial skeleton. It includes both radiographic (r-axSpA) and non-radiographic (nr-axSpA) forms.
Karolina Kopeć, Aleksandra Bartoszek , Julia Adamiuk , Agnieszka Marut, Marta Biskup, Jagoda Misiuk, Adriana Skuba, Katarzyna Załuska, Wiktoria Śmigiel , Agnieszka Świdniak   +9 more
doaj   +1 more source

In Vitro Evaluation of Lipopolyplexes for Gene Transfection: Comparing 2D, 3D and Microdroplet-Enabled Cell Culture

Molecules, 2020
Complexes combining nucleic acids with lipids and polymers (lipopolyplexes) show great promise for gene therapy since they enable compositional, physical and functional versatility to be optimized for therapeutic efficiency.
Juan L. Paris, Filipe Coelho, Alexandra Teixeira, Lorena Diéguez, Bruno F. B. Silva, Sara Abalde-Cela   +5 more
doaj   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

2-(3-Cyano-4-{3-[1-(2-hydroxyethyl)-3,3-dimethyl-1,3-dihydroindol-2-ylidene]prop-2-enyl}-5,5-dimethyl-5H-furan-2-ylidene)malononitrile

Acta Crystallographica Section E, 2014
The title compound, C25H24N4O2, adopts a cisoid configuration and has twofold orientational disorder of the 2-hydroxyethyl group. The molecule is twisted from planarity so that the dihedral angle between the terminating indol-2-ylidene and the furan-2 ...
Graeme J. Gainsford, M. Delower H. Bhuiyan, Andrew J. Kay   +2 more
doaj   +1 more source

An Approach for Shipping Emissions Estimation in Ports: The Case of Ro–Ro Vessels in Port of Vigo

Journal of Marine Science and Engineering, 2023
Despite most atmospheric emissions being produced by vessels when navigating at sea, they are also important when in port because of their proximity to urban areas and their harmful effects on climate change and health.
Ana B. Albo-López, Camilo Carrillo, Eloy Díaz-Dorado   +2 more
doaj   +1 more source

XMM-Newton Observation of IC 310 in the Outer Region of the Perseus Cluster of Galaxies

, 2005
We present results from an XMM-Newton observation of the head-tail radio galaxy IC 310 located in the southwest region of the Perseus cluster. The spectrum is well-fitted by an absorbed power-law model with a photon index of $2.50 \pm 0.02$ with no ...
Furusho, T., Ishida, M., Matsushita, K., Ohashi, T., Sato, K., Yamasaki, N. Y.   +5 more
core   +5 more sources

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source

Comparison of the impact of e-cigarettes and new tobacco heating devices on the human body and their potential in the fight against smoking

Journal of Education, Health and Sport, 2022
Nicotine is one of the most common stimulants used by humans in the world. Its addictive potential is almost the same as that of cocaine. [1] The most popular way of delivering nicotine to the body, which is cigarette smoking, has many negative effects,
Kamil Pondel, Kinga Kawałko, Krzysztof Bielewicz, Katarzyna Skowrońska, Patrycja Baciur   +4 more
doaj   +1 more source

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source