Results 161 to 170 of about 335,877 (277)

Impact of Dual Interleukin‐17A and Interleukin‐17F Inhibition with Bimekizumab on Inflammatory and Structural Lesions in Axial Spondyloarthritis: MRI and Radiographic Outcomes from the Phase 3 BE MOBILE 1 and 2 Studies and their Open‐Label Extension

open access: yesArthritis &Rheumatology, Accepted Article.
Objectives To evaluate the impact of bimekizumab, a dual IL‐17A and IL‐17F inhibitor, on sacroiliac joint (SIJ) and spine inflammation/structural damage in axSpA using MRIs/radiographs from the phase 3 studies BE MOBILE 1 (nr‐axSpA) and 2 (r‐axSpA) and their open‐label extension (OLE).
Walter P. Maksymowych   +10 more
wiley   +1 more source

MDL‐800‐induced SIRT6 activation decreases age‐associated osteoarthritis in mice

open access: yesArthritis &Rheumatology, Accepted Article.
Objective SIRT6 is a nuclear‐localized histone deacetylase that regulates multiple pathways associated with aging. This study aimed to determine whether systemic administration of a small molecule activator of SIRT6, MDL‐800, decreases the severity of age‐associated osteoarthritis (OA) in mice.
Matheus Moreira Perez   +13 more
wiley   +1 more source

Alarming bradycardia in a patient with Dengue fever [PDF]

open access: yesAl Ameen Journal of Medical Sciences, 2016
I.A. Khan   +3 more
doaj  

Trajectory analysis in clinical research. [PDF]

open access: yesClin Kidney J
D'Arrigo G   +7 more
europepmc   +1 more source

Associating cognitive abilities with naturalistic search behavior

open access: yesJournal of the Association for Information Science and Technology, Volume 76, Issue 4, Page 665-685, April 2025.
Abstract Differences in cognitive abilities affect search behaviors, but this has mostly been observed in laboratory experiments. There is limited research on how users search for information in real‐world, naturalistic settings and how real‐world search behaviors relate to cognitive abilities.
Tung Vuong   +2 more
wiley   +1 more source

Principal Component‐Based Classification of Blazar Candidates of Uncertain Type in the 4FGL/LAT

open access: yesAstronomische Nachrichten, EarlyView.
ABSTRACT We adopted principal component analysis (PCA), linear discriminant analysis (LDA), and support vector machines (SVM), to study classification for a sample of 2708 Fermi blazars: 1142 BL Lac objects (BLLs), 759 flat spectrum radio quasars (FSRQs), and 807 blazar candidates of uncertain type (BCUs).
Wen‐Xin Yang   +13 more
wiley   +1 more source

Impact of delayed medical consultation on dengue severity and mortality during the 2023 outbreak in Burkina Faso. [PDF]

open access: yesIJID Reg
Ouedraogo D   +6 more
europepmc   +1 more source

Evaluating the (comparative) safety profile of the novel oral polio vaccine type 2 using individual case safety reports in VigiBase

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aim Novel oral polio vaccine type 2 (nOPV2) was used under the WHO emergency use listing for circulating vaccine‐derived polio virus (cVDPV) outbreaks from 2021 to 2023. We assessed nOPV2 adverse events following immunization (AEFIs) and compared its safety profile to other vaccines using VigiBase.
Comfort Kunak Ogar   +6 more
wiley   +1 more source

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