Results 31 to 40 of about 324,581 (238)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Data Set S4 - Offsets applied to cores from IODP Holes 342-U1408A, 342-U1408B, 342-U1408C

, 2019
Data Set S4 - Offsets applied to cores from IODP Holes 342-U1408A, 342-U1408B, 342 ...
Paul R Bown (6964958), Steven M Bohaty (6963266), Westerhold, Thomas, Carlotta Cappelli (8286180), Veronica Lobba (8286186), Martina de Riu (8286183), Cappelli, Carlotta, Lobba, Veronica, Agnini, Claudia, Yamamoto, Yuhji, Yuhji Yamamoto (7983032), de Riu, Martina, Bohaty, Steven M, Thomas Westerhold (6960026), Bown, Paul R, Claudia Agnini (7908953)   +15 more
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Presidential Control of High Courts in Latin America: A Long-term View (1904-2006) Control presidencial de las cortes supremas en América Latina. Una mirada histórica (1904-2006)

Journal of Politics in Latin America, 2009
In many Latin American countries the executive branch manipulatesthe composition of the Supreme Court, and judicial independence hasremained elusive. Because high courts can exercise judicial review and influencelower courts, incoming presidents often ...
Aníbal Pérez-Liñán, Andrea Castagnola   +1 more
doaj  

Risk Factors for Periprosthetic Infection Following Limb Salvage Surgery in Bone Sarcomas

Onco
Background: Multimodal treatment of bone sarcomas has improved survival and allowed limb salvage surgery in the majority of these patients. Periprosthetic joint infection (PJI) constitutes a challenging complication.
Diogo Nóbrega Catelas, Lucinda Correia, Alexandra Santos, Catarina Pereira, Diogo Rodrigues, Afonso Faria, Guilherme Madeira, Pedro Cardoso, Vânia Oliveira   +8 more
doaj   +1 more source

Domain Structure and Magnetization Reversal Mechanism in Co/Pd Nanopatterned Multilayer

Proceedings, 2019
Fabrication and modeling of patterned thin films with perpendicular. [...]
Paweł Sobieszczyk, Michał Krupiński, Piotr Zieliński, Marta Marszałek   +3 more
doaj   +1 more source

Investigations of Muon Flux Variations Detected Using Veto Detectors of the Digital Gamma-rays Spectrometer

Applied Sciences, 2021
This paper presents the results of cosmic ray muons flux monitoring registered by a digital gamma-ray spectrometer’s active shield made of five large plastic scintillators.
Krzysztof Gorzkiewicz, Jerzy W. Mietelski, Zbigniew Ustrnul, Piotr Homola, Renata Kierepko, Ewa Nalichowska, Kamil Brudecki   +6 more
doaj   +1 more source

Data Set S1 - Offsets applied to cores from IODP Holes 342-U1410A, 342-U1410B, 342-U1410C

, 2019
Data Set S1 - Offsets applied to cores from IODP Holes 342-U1410A, 342-U1410B, 342 ...
Paul R Bown (6964958), Steven M Bohaty (6963266), Westerhold, Thomas, Carlotta Cappelli (8286180), Veronica Lobba (8286186), Martina de Riu (8286183), Cappelli, Carlotta, Lobba, Veronica, Agnini, Claudia, Yamamoto, Yuhji, Yuhji Yamamoto (7983032), de Riu, Martina, Bohaty, Steven M, Thomas Westerhold (6960026), Bown, Paul R, Claudia Agnini (7908953)   +15 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Influence of Different Levels of Fertilizer and Post-Emergence Herbicides on Weed Control Efficiency, Nutrient Depletion by Weeds and Production of Wheat [Triticum aestivum (L.)]

International Journal of Bio-Resource and Stress Management, 2022
The field studies were conducted at Instructional Farm, College of Agriculture, Jodhpur (Agriculture University, Jodhpur), Rajasthan, India on Wheat during rabi seasons (November to April) of both the 2018–2019 and 2019–2020.
Sarita, Ishwar Singh, M. L. Mehriya
doaj