Results 91 to 100 of about 235,900 (237)

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

EDTA‐Functionalized Nanoscale Metal–Organic Framework for Onco‐Cardiology via Radiochemotherapy Synergy and Spatiotemporally Matched Iron Chelation

Advanced Science, EarlyView.
Doxorubicin (DOX)‐induced cardiotoxicity is a major limitation to its broader clinical application, while cardioprotective interventions often risk reducing the anticancer efficacy of DOX. To address these challenges, this work constructs an EDTA‐functionalized metal–organic framework that enhances tumor therapy and provides efficient cardioprotection ...
Daojing Yuan, Liyang Tian, Luwen Zhuang, Yongyu Liang, Lingfei Chen, Xuetao Wang, Yanli Li, Xiyong Yu, Teng Gong   +8 more
wiley   +1 more source

Activity of Aztreonam/Avibactam and Recently Approved β-Lactamase Inhibitor Combinations against Enterobacterales and Pseudomonas aeruginosa from Intensive Care Unit and Non-Intensive Care Unit Patients

Antibiotics
We evaluated the activities of aztreonam/avibactam and recently approved β-lactamase inhibitor combinations (BLICs) to compare the antimicrobial susceptibility patterns of Enterobacterales and Pseudomonas aeruginosa isolated from intensive care unit (ICU)
Helio S. Sader, Rodrigo E. Mendes, John H. Kimbrough, Cory M. Hubler, Mariana Castanheira   +4 more
doaj   +1 more source

Expanding the Chemical Space of Cyclic Polyphthalaldehyde via Post‐Functionalization

Advanced Science, EarlyView.
In this work, we developed a post‐functionalization approach to achieve water‐soluble cyclic polyphthalaldehyde (cPPA) polymers via click chemistry. ABSTRACT Cyclic polyphthalaldehydes (cPPAs) are hydrophobic cyclic polymers with stimuli‐responsive depolymerization property. The introduction of hydrophilic functionalities to cPPAs is challenging due to
Liting He, Haiyan Zhou, Qiushi Chen, Xing Guo, Han Liu, Xuechen Li   +5 more
wiley   +1 more source

Unveiling Copper‐Induced Phase Transitions and Degradation Mechanisms of Transition Metal Sulfide Anodes for Sodium‐Ion Batteries

Advanced Science, EarlyView.
Sodium polysulfides, which are generated from TMS anodes, react with the Cu current collector, thereby triggering Na‐Cu–S interfacial phase formation. Simultaneously, transition metals undergo ionization and redeposition on the counter electrode. The coupled processes drive the phase evolution of TMS toward the stable Cu1.8S phase.
Jacob Choe, Junpyo Hur, Sanghyeon Park, Jeongmin Kim, Jaeeun Joo, Jae Yeol Park, Chan‐Woo Lee, Jong Min Yuk   +7 more
wiley   +1 more source

Interplay Between Structure and Interfacial Interactions in Fe‐Gd Synthetic Ferrimagnets

Advanced Electronic Materials, EarlyView.
Synthetic ferrimagnets with nearly identical Gd–Fe compositions but different architectures and crystallinity were investigated by element‐resolved microscopy, structural analysis and atomistic spin simulations. The results show that Curie temperature and domain evolution are governed primarily by structural order and interface quality, demonstrating ...
Álvaro González‐García, Alejandro Álvarez‐Chico, Jairo Obando‐Guevara, Silvia Gallego, Unai Atxitia, Iulia Cojocariu, Matteo Jugovac, Tevfik Onur Menteş, Andrea Locatelli, Arantzazu Mascaraque, Miguel Ángel González‐Barrio   +10 more
wiley   +1 more source

Aqueous Zinc‐Based Batteries: Active Materials, Device Design, and Future Perspectives

Advanced Energy Materials, EarlyView.
This review conducts a comprehensive analysis of aqueous zinc‐based batteries (AZBs) based on their intrinsic mechanisms, including redox reactions, ion intercalation reactions, alloying reactions, electrochemical double‐layer reactions, and mixed mechanisms, systematically discussing recent advancements in each type of AZBs.
Yan Ran, Fang Dong, Shuhui Sun, Yong Lei
wiley   +1 more source

Beyond Imperfect Match: Silicon/Graphite Hybrid Anodes for High‐Energy–Density Lithium‐Ion Batteries

Advanced Energy Materials, EarlyView.
Silicon/graphite (Si/Gr) hybrid anodes are limited by Si's large volume change and mismatch with Gr. This review offers mechanistic insights into imperfectly matched Si/Gr hybrid anodes, elucidating heterogeneous lithiation behavior and interfacial failure pathways, and thereby informing the design of durable, high‐energy–density lithium‐ion batteries.
Jing Li, Karol Viviana Mejía‐Centeno, Malik Dilshad Khan, Guifang Zeng, Lijie Ci, Andreu Cabot, Qing Sun   +6 more
wiley   +1 more source

Stability of Perovskite Indoor Photovoltaics: A Focused Review and a Call for Standardized Stability Reporting

Advanced Energy Materials, EarlyView.
While perovskite solar cells have been widely studied, including their stability, perovskite indoor photovoltaics (IPVs) have only recently emerged. Nevertheless, more studies are appearing in the literature. The systematic stability study of IPVs is crucial, particularly given the inconsistencies in reported methodologies and results, which call for ...
Ivy Mawusi Asuo, Arezo Mahdavi Varposhti, Cyril Chu Fubin Kumachang, Gopal Krishnamurthy Grandhi, Vincenzo Pecunia, Thomas Meredith Brown, Paola Vivo, Nutifafa Yao Doumon   +7 more
wiley   +1 more source

Assessing Haitian Consumers' Willingness to Pay a Premium for Aflatoxin‐Compliant Peanut Butter in the Informal Market

Agribusiness, EarlyView.
ABSTRACT Market‐based solutions are increasingly tested to address aflatoxin issues in peanuts in developing countries. Although previous studies have found that Haitian grocery store shoppers are willing to pay a 21% premium for peanut butter with levels of aflatoxin that meet international standards, no information is available for the much larger ...
Phendy Jacques, Stevens Azima, Maurice Doyon   +2 more
wiley   +1 more source