Results 91 to 100 of about 2,158,309 (327)

p16Ink4a‐Positive Hepatocytes Drive Liver Fibrosis Through Activation of LIFR Family Pathway

Advanced Science, EarlyView.
This study found that, following the long‐term CCl4 treatment, p16high hepatocytes appeared in zone 3, spatially co‐localizing with fibrotic areas. A specific cluster of p16high hepatocytes upregulated CTF1/LIF expression which induced HSC activation and further liver fibrosis, as revealed by single cell transcriptomic analysis.
Koji Nishikawa, Teh‐Wei Wang, Satoshi Kawakami, Shota Tanimoto, Kiyoshi Yamaguchi, Taketomo Kido, Masamichi Kimura, Tsunekazu Hishima, Yuki T. Okamura, Satotaka Omori, Takumi Iritani, Toshikaze Chiba, Takehiro Jimbo, Michio Katano, Kansuporn Kamataki, Ryoichi Yokoyama, Eigo Shimizu, Kiminori Kimura, Satoshi Yamzaki, Seiya Imoto, Yoichi Furukawa, Atsushi Miyajima, Yoshikazu Johmura, Makoto Nakanishi   +23 more
wiley   +1 more source

miR‑379 inhibits cell proliferation and epithelial‑mesenchymal transition by targeting CHUK through the NF‑κB pathway in non‑small cell lung cancer.

Molecular Medicine Reports, 2019
An increasing body of evidence has demonstrated that microRNA (miR) deregulation serves pivotal roles in tumor progression and metastasis. However, the function of miR‑379 in lung cancer remains understudied, particularly in non‑small cell lung cancer ...
Bin Liu, Z. Wang, Shizhao Cheng, Lin Du, Yanjun Yin, Zhen Yang, Jingmin Zhou   +6 more
semanticscholar   +1 more source

RNF213 Is an Interferon‐Stimulated Gene That Targets Influenza A Virus NP and Activates MDA5 to Restrict Infection

Advanced Science, EarlyView.
RNF213 is characterized as a dual‐functional antiviral effector. It directly mediates the degradation of the influenza A virus nucleoprotein (NP) while simultaneously activating the MDA5‐mediated innate immune signaling pathway. This coordinated response establishes a powerful host defense system against viral infection. ABSTRACT Influenza A virus (IAV)
Haoning Li, Yuying Zhang, Jingjing Wang, Qianqian Zhang, Hailiang Sun, Fanhua Wei   +5 more
wiley   +1 more source

Serum miR-379 expression is related to the development and progression of hypercholesterolemia in non-alcoholic fatty liver disease.

PLoS ONE, 2020
INTRODUCTION:Non-alcoholic fatty liver disease (NAFLD) has a wide spectrum, eventually leading to cirrhosis and hepatic carcinogenesis. We previously reported that a series of microRNAs (miRNAs) mapped in the 14q32.2 maternally imprinted gene region ...
Kinya Okamoto, Masahiko Koda, Toshiaki Okamoto, Takumi Onoyama, Kenichi Miyoshi, Manabu Kishina, Tomomitsu Matono, Jun Kato, Shiho Tokunaga, Takaaki Sugihara, Akira Hiramatsu, Hideyuki Hyogo, Hiroshi Tobita, Shuichi Sato, Miwa Kawanaka, Yuichi Hara, Keisuke Hino, Kazuaki Chayama, Yoshikazu Murawaki, Hajime Isomoto   +19 more
doaj   +1 more source

MicroRNA-379-5p is associated with biochemical premature ovarian insufficiency through PARP1 and XRCC6

Cell Death and Disease, 2018
Premature ovarian insufficiency (POI) imposes great challenges on women’s fertility and lifelong health. POI is highly heterogeneous and encompasses occult, biochemical, and overt stages.
Yujie Dang, Xiaoyan Wang, Yajing Hao, Xinyue Zhang, Shidou Zhao, Jin-long Ma, Yingying Qin, Zi-jiang Chen   +7 more
semanticscholar   +1 more source

Stabilization of Single Metal Atoms on Graphitic Carbon Nitride: Synthetic Strategies and Emerging Applications

Advanced Science, EarlyView.
This review highlights recent advancements in stabilizing single metal atoms on graphitic carbon nitride emphasizing innovative synthesis strategies and emerging applications in electrocatalysis, photocatalysis and organic transformations, along with key challenges and future perspective. Abstract Emerging as a new frontier in catalysis science, single‐
Wenyao Zhang, Junjie Cui, Zhenjie Yao, Boyuan Zhu, Nithinraj Panangattu Dharmarajan, Ajayan Vinu, Junwu Zhu   +6 more
wiley   +1 more source

BL LAC PKSB1144-379 an extreme scintillator

, 2012
Rapid variability in the radio flux density of the BL Lac object PKSB1144-379 has been observed at four frequencies, ranging from 1.5 to 15 GHz, with the VLA and the University of Tasmania's Ceduna antenna.
Baars, Bignall, Bolton, Camenzind, Cordes, Dennett-Thorpe, Gardner, Kedziora-Chudczer, Lovell, Lovell, Ma, McCulloch, Nicolson, Senkbeil, Shimmins, Stickel, Stinebring   +16 more
core   +1 more source

mir-374-5p, mir-379-5p, and mir-503-5p Regulate Proliferation and Hypertrophic Differentiation of Growth Plate Chondrocytes in Male Rats

Endocrinology, 2018
Growth plate chondrocytes undergo sequential differentiation to form the resting zone, the proliferative zone (PZ), and the hypertrophic zone (HZ). The important role of microRNAs (miRNAs) in the growth plate was previously revealed by cartilage-specific
Y. Jee, JIN-HANG Wang, Shanna Yue, Melissa S. Jennings, S. Clokie, O. Nilsson, J. Lui, J. Baron   +7 more
semanticscholar   +1 more source

NanoLoop: A Deep Learning Framework Leveraging Nanopore Sequencing for Chromatin Loop Prediction

Advanced Science, EarlyView.
Chromatin loops are central to gene regulation and 3D genome organization. Leveraging Nanopore sequencing's ability to jointly capture DNA sequence and methylation, we present NanoLoop, the first framework for genome‐wide chromatin loop prediction using Nanopore data.
Wenjie Huang, Li Tang, Matthew C. Hill, Yonghao Zhang, Jun Xie, Min Li   +5 more
wiley   +1 more source

Lysophosphatidylethanolamine in Grifola frondosa as a neurotrophic activator via activation of MAPK

Journal of Lipid Research, 2006
We found that Grifola frondosa extracts induced the activation of mitogen-activated protein kinase (MAPK) in cultured PC12 cells, a line of rat pheochromocytoma cells.
Atsuyoshi Nishina, Hirokazu Kimura, Akihiro Sekiguchi, Ryo-hei Fukumoto, Satoshi Nakajima, Shoei Furukawa   +5 more
doaj   +1 more source