Results 1 to 10 of about 4,116 (175)

miR-379-5p Inhibited the Proliferation of Acute Myeloid Leukemia Cells Through Negative Regulation of YBX1 [PDF]

Turkish Journal of Hematology
Objective: Acute myeloid leukemia (AML) highly lethal hematological malignancy that is difficult to treat. This study aimed to clarify the molecular mechanisms of miR-379-5p in AML progression.
Huichao Wu, Lin Zhao, Huanyu Guo, Yingjie Xie, Jianhua Hu, Xinxia Tan   +5 more
doaj   +6 more sources

miR-379-5p affects breast cancer cell behavior by targeting UBE2E3 ubiquitin conjugating enzyme. [PDF]

PLoS ONE
MicroRNAs (miRNAs) play an increasingly recognized role in modulating cancer development. Due to their function in regulating gene expression, miRNAs can suppress or promote tumorigenesis. miR-379-5p expression is downregulated in multiple human cancers,
Araya K Schroder, Conor J Loy, Fernanda Aiala, Jazmyn Rafique, Arnob Ghosh, Lina I Yoo   +5 more
doaj   +8 more sources

MiR‐379‐5p inhibits the proliferation, migration, and invasion of breast cancer by targeting KIF4A [PDF]

Thoracic Cancer, 2022
Background Many studies have shown that microRNAs (miRNAs) play an essential role in gene regulation and tumor development. This study aimed to explore the expression of miR‐379‐5p and its mechanisms of affecting proliferation, migration, and invasion in
Ke Yang, Hongli Li, Yunbo Sun
exaly   +5 more sources

MiR-379-5p aggravates experimental autoimmune uveitis in mice via the regulation of SEMA3A

Autoimmunity, 2021
Uveitis is a disease resulting in the inflammation of uveal tracts, but the factors resulting in uveitis is still obscure. Previous studies have shown that miR-379-5p was involved in the pathogenesis of several diseases, however, the role and regulatory ...
Mohan Li, Xiang Gao, Kou Liu, Ning Bao, Zhengxuan Jiang   +4 more
exaly   +4 more sources

Androgen-induced exosomal miR-379-5p release determines granulosa cell fate: cellular mechanism involved in polycystic ovaries [PDF]

Journal of Ovarian Research, 2023
Polycystic ovarian syndrome (PCOS) is a complex multi-factorial syndrome associated with androgen excess and anovulatory infertility. In the current study, we investigated the role of dihydrotestosterone-induced exosomal miR-379-5p release in determining
Reza Salehi, Brandon A. Wyse, Meshach Asare-Werehene, Fereshteh Esfandiarinezhad, Atefeh Abedini, Bo Pan, Yoko Urata, Alex Gutsol, Jose L. Vinas, Sahar Jahangiri, Kai Xue, Yunping Xue, Kevin D. Burns, Barbara Vanderhyden, Julang Li, Yutaka Osuga, Dylan Burger, Seang-Lin Tan, Clifford L. Librach, Benjamin K. Tsang   +19 more
doaj   +5 more sources

miR-379-5p retards the proliferation and differentiation of goat skeletal muscle satellite cells by targeting LIN28B [PDF]

Frontiers in Veterinary Science
MicroRNAs (miRNAs) are emerging as crucial regulators of skeletal muscle development and regeneration; however, the biological functions of many miRNAs remain to be elucidated.
Wenyue Hou, Shiyu Huang, Zihao Zhao, Xiaoli Xu, Hongping Zhang, Jiazhong Guo, Jiaxue Cao, Dinghui Dai, Li Li   +8 more
doaj   +4 more sources

Granulosa cell-derived miR-379-5p regulates macrophage polarization in polycystic ovarian syndrome [PDF]

Frontiers in Immunology, 2023
Polycystic ovarian syndrome (PCOS) is associated with hyperandrogenemia and ovarian antral follicle growth arrest. We have previously demonstrated that androgen-induced exosomal release of miR-379-5p (miR379) from preantral follicle granulosa cells ...
Reza Salehi, Reza Salehi, Reza Salehi, Reza Salehi, Meshach Asare-Werehene, Meshach Asare-Werehene, Meshach Asare-Werehene, Brandon A. Wyse, Atefeh Abedini, Bo Pan, Alex Gutsol, Sahar Jahangiri, Peter Szaraz, Kevin D. Burns, Barbara Vanderhyden, Barbara Vanderhyden, Barbara Vanderhyden, Julang Li, Dylan Burger, Dylan Burger, Dylan Burger, Clifford L. Librach, Clifford L. Librach, Clifford L. Librach, Clifford L. Librach, Benjamin K. Tsang, Benjamin K. Tsang, Benjamin K. Tsang   +27 more
doaj   +4 more sources

Circ_0010235 confers cisplatin resistance in lung cancer by upregulating E2F7 through absorbing miR‐379‐5p [PDF]

Thoracic Cancer, 2023
Background Cisplatin (DDP) treatment is one of the most predominant chemotherapeutic strategies for lung cancer patients. Circular RNAs (circRNAs) have been revealed to participate in the chemoresistance in lung cancer.
Lifei Wang, Dongchang Wang, Zhen Xu, Yali Qiu, Gang Chen, Furong Tan   +5 more
doaj   +4 more sources

Memory-promoting function of miR-379-5p attenuates CD8+ T cell exhaustion by targeting immune checkpoints [PDF]

Journal for ImmunoTherapy of Cancer
Background MicroRNAs (miRNAs) are epigenetic regulators of T cell maturation and exhaustion. However, the mechanisms by which miRNAs influence T cell function in tumor environments remain unclear.
Chia-Hsin Liu, Hong-Wei Li, Liang-Chih Liu, You-Zhe Lin, Wan-Rong Wu, Ting-Yi Liao, Chuan-Chun Lee, Feng-Chi Chung, Yi-Chun Shen, Guan-Yu Zhuo, Wei-Chung Cheng, Shao-Chun Wang   +11 more
doaj   +4 more sources

Total flavonoids of Abelmoschus manihot (L.) medic attenuate early renal injury in diabetic kidney disease by modulating the LINC00665/miR-379-5p axis [PDF]

Pharmaceutical Biology
‌Context:‌ Huangkui capsule (HKC), derived from Abelmoschus manihot (L.) Medic, is clinically utilized for diabetic kidney disease (DKD) treatment. Its primary bioactive components are the total flavonoids of A. manihot (L.) (TFA).
Nan Li, Yuhe Zeng, Yaohui Fang, Jie Wu, Harvest F. Gu, Ying Wang   +5 more
doaj   +4 more sources