hsa_circ_0008305 facilitates the malignant progression of hepatocellular carcinoma by regulating AKR1C3 expression and sponging miR-379-5p [PDF]
Scientific ReportsCircular RNAs (circRNAs) are widely involved in diverse biological processes of cancers. Nonetheless, the potential function of hsa_circ_0008305 in hepatocellular carcinoma (HCC) remains largely unknown.
Shenglan Huang +5 more
doaj +4 more sources
Expression Analysis of miR-519a-3p and miR-379-5p in Colorectal Cancer Patients: A Combined Experimental and Bioinformatic Approach [PDF]
DiagnosticsBackground/Objectives: Colorectal cancer (CRC) is one of the most common malignancies worldwide. microRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression post-transcriptionally and have emerged as important regulators in cancer
Turkan Gurer +3 more
doaj +4 more sources
MiR-379-5p aggravates experimental autoimmune uveitis in mice via the regulation of SEMA3A
Autoimmunity, 2021 Uveitis is a disease resulting in the inflammation of uveal tracts, but the factors resulting in uveitis is still obscure. Previous studies have shown that miR-379-5p was involved in the pathogenesis of several diseases, however, the role and regulatory ...
Mohan Li +4 more
doaj +3 more sources
MIR-379-5p Expression in Endometrial Cancer and Its Correlation with ROR1 Expression. [PDF]
Asian Pac J Cancer Prev, 2023 To asses miR-379-5p expression in endometrial cancer (EC) and its correlation with ROR1 expression and to investigate the relation between miR-379-5p and ROR1 expressions and the clinicopathological picture of EC.Fifty female of EC were joined to this study.
Mosaad H +6 more
europepmc +3 more sources
Gazi Medical JournalObjective: To develop an optimized polyethylenimine (PEI)-based nanocarrier for the intracellular delivery of miR-379-5p and to evaluate its efficacy in suppressing the oncogenic targets metadherin (MTDH) and Forkhead box P2 (FOXP2) in KRAS-wild-type ...
Ekin Çelik +6 more
doaj +2 more sources
Linchuang shenzangbing zazhi, 2022 ObjectiveTo explore the effect of chikusetsu saponin Ⅳa （CHS） on high glucose-induced human renal tubular epithelial cells （HK-2） injury and examine whether or not its mechanism is correlated with the regulation of circEIF4G2 and miR-379-5p expression ...
Qin Li +3 more
doaj +1 more source
MiR-379-5p Promotes Chondrocyte Proliferation via Inhibition of PI3K/Akt Pathway by Targeting YBX1 in Osteoarthritis. [PDF]
Cartilage, 2022 Objective We evaluated the ability of miR-379-5p to influence the proliferation of osteoarthritis chondrocytes and elucidated the regulatory mechanism of miR-379-5p in osteoarthritis. Methods Real time polymerase chain reaction (RT ...
Zhang H, Zheng W, Li D, Zheng J.
europepmc +4 more sources
LINC00665 promotes breast cancer progression through regulation of the miR-379-5p/LIN28B axis. [PDF]
Cell Death Dis, 2020 AbstractBreast cancer is the most common malignant tumor among women worldwide. Although increasing evidence indicates that long noncoding RNAs (lncRNAs) play critical roles during breast tumorigenesis and progression, the involvement of most lncRNAs in breast cancer remains largely unknown. In the current study, we demonstrated that LINC00665 promotes
Ji W +5 more
europepmc +4 more sources
miR-379-5P INHIBITION ENHANCES INTESTINAL EPITHELIAL PROLIFERATION AND BARRIER FUNCTION RECOVERY AFTER ISCHEMIA/REPERFUSION BY TARGETING EIF4G2. [PDF]
Shock, 2023 ABSTRACT Gut barrier dysfunction caused by intestinal ischemia/reperfusion (I/R) injury is associated with substantial death and morbidity. In this research, the role of microRNAs (miRNAs) in regulating intestinal I/R injury was investigated. We used miRNA sequencing to analyze clinical ischemic and normal intestinal samples.
Jia Z +5 more
europepmc +3 more sources
Blocking hsa_circ_0074027 suppressed non-small cell lung cancer chemoresistance via the miR-379-5p/IGF1 axis. [PDF]
Bioengineered, 2021 Cancer cell chemoresistance is the primary reason behind cancer treatment failure. Previous reports suggest that circular RNA (circRNA) hsa_circ_0074027 (HC0074027) is a crucial modulator of non-small cell lung cancer (NSCLC) disease progression. Herein, we delineated the underlying mechanism of HC0074027-regulated chemoresistance in NSCLC. We employed
Zheng S, Wang C, Yan H, Du Y.
europepmc +4 more sources