Results 11 to 20 of about 248,159 (173)

Memory-promoting function of miR-379-5p attenuates CD8+ T cell exhaustion by targeting immune checkpoints [PDF]

Journal for ImmunoTherapy of Cancer
Background MicroRNAs (miRNAs) are epigenetic regulators of T cell maturation and exhaustion. However, the mechanisms by which miRNAs influence T cell function in tumor environments remain unclear.
Chia-Hsin Liu, Hong-Wei Li, Liang-Chih Liu, You-Zhe Lin, Wan-Rong Wu, Ting-Yi Liao, Chuan-Chun Lee, Feng-Chi Chung, Yi-Chun Shen, Guan-Yu Zhuo, Wei-Chung Cheng, Shao-Chun Wang   +11 more
doaj   +6 more sources

Expression Analysis of miR-519a-3p and miR-379-5p in Colorectal Cancer Patients: A Combined Experimental and Bioinformatic Approach [PDF]

Diagnostics
Background/Objectives: Colorectal cancer (CRC) is one of the most common malignancies worldwide. microRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression post-transcriptionally and have emerged as important regulators in cancer
Turkan Gurer, Mehmet Emin Kizakoglu, Alper Aytekin, Rusen Avsar   +3 more
doaj   +6 more sources

hsa_circ_0008305 facilitates the malignant progression of hepatocellular carcinoma by regulating AKR1C3 expression and sponging miR-379-5p [PDF]

Scientific Reports
Circular RNAs (circRNAs) are widely involved in diverse biological processes of cancers. Nonetheless, the potential function of hsa_circ_0008305 in hepatocellular carcinoma (HCC) remains largely unknown.
Shenglan Huang, Kan Liu, Yongkan Xu, Hua Wang, Shumin Fu, Jianbing Wu   +5 more
doaj   +6 more sources

MiR-379-5p Promotes Chondrocyte Proliferation via Inhibition of PI3K/Akt Pathway by Targeting YBX1 in Osteoarthritis [PDF]

Cartilage, 2022
Objective We evaluated the ability of miR-379-5p to influence the proliferation of osteoarthritis chondrocytes and elucidated the regulatory mechanism of miR-379-5p in osteoarthritis. Methods Real time polymerase chain reaction (RT ...
Wendi Zheng, Jia Zheng, Jia Zheng
exaly   +5 more sources

Blocking hsa_circ_0074027 suppressed non-small cell lung cancer chemoresistance via the miR-379-5p/IGF1 axis [PDF]

Bioengineered, 2021
Cancer cell chemoresistance is the primary reason behind cancer treatment failure. Previous reports suggest that circular RNA (circRNA) hsa_circ_0074027 (HC0074027) is a crucial modulator of non-small cell lung cancer (NSCLC) disease progression. Herein, we delineated the underlying mechanism of HC0074027-regulated chemoresistance in NSCLC. We employed
Yuejun Du
exaly   +5 more sources

LINC00665/miR-379-5p/GRP78 regulates cisplatin sensitivity in gastric cancer by modulating endoplasmic reticulum stress [PDF]

Cytotechnology, 2021
Acquired resistance to cisplatin (DDP)-based chemotherapy greatly hinders the treatment of gastric cancer (GC). LINC00665 serves as an oncogene in GC. Hence, the current study was designed to investigate the regulatory effects of LINC00665 on DDP-resistance of GC.
Lin Xu, Yue Chao
exaly   +4 more sources

mir-374-5p, mir-379-5p, and mir-503-5p Regulate Proliferation and Hypertrophic Differentiation of Growth Plate Chondrocytes in Male Rats. [PDF]

Endocrinology, 2018
Growth plate chondrocytes undergo sequential differentiation to form the resting zone, the proliferative zone (PZ), and the hypertrophic zone (HZ). The important role of microRNAs (miRNAs) in the growth plate was previously revealed by cartilage-specific ablation of Dicer, an enzyme essential for biogenesis of many miRNAs.
Jee YH, Wang J, Yue S, Jennings M, Clokie SJ, Nilsson O, Lui JC, Baron J.   +7 more
europepmc   +6 more sources

Additional file 1 of Androgen-induced exosomal miR-379-5p release determines granulosa cell fate: cellular mechanism involved in polycystic ovaries [PDF]

, 2023
Additional file 1: Supplementary Figure 1. Androgen excess in human PCOS subjects is associated with reduced follicular fluid-derived exosomal mir-379-5p content and granulosa cell proliferation. (A) Follicular fluids from the dominant follicles (≥ 20 mm; n = 25 Non-PCOS and 13 PCOS subjects) of PCOS subjects exhibited significantly higher free ...
Salehi, Reza, Wyse, Brandon A., Asare-Werehene, Meshach, Esfandiarinezhad, Fereshteh, Abedini, Atefeh, Pan, Bo, Urata, Yoko, Gutsol, Alex, Vinas, Jose L., Jahangiri, Sahar, Xue, Kai, Xue, Yunping, Burns, Kevin D., Vanderhyden, Barbara, Li, Julang, Osuga, Yutaka, Burger, Dylan, Tan, Seang-Lin, Librach, Clifford L., Tsang, Benjamin K.   +19 more
openaire   +2 more sources

MIR-379-5p Expression in Endometrial Cancer and Its Correlation with ROR1 Expression. [PDF]

Asian Pac J Cancer Prev, 2023
To asses miR-379-5p expression in endometrial cancer (EC) and its correlation with ROR1 expression and to investigate the relation between miR-379-5p and ROR1 expressions and the clinicopathological picture of EC.Fifty female of EC were joined to this study.
Mosaad H, Abdelrahman AE, Abdullatif A, Lashin ME, Ramadan MSH, El-Azony A, Hussien MHS.   +6 more
europepmc   +3 more sources

Polyethylenimine-Mediated Delivery of miR-379-5p Suppresses MTDH and FOXP2 in Colorectal Cancer Cells

Gazi Medical Journal
Objective: To develop an optimized polyethylenimine (PEI)-based nanocarrier for the intracellular delivery of miR-379-5p and to evaluate its efficacy in suppressing the oncogenic targets metadherin (MTDH) and Forkhead box P2 (FOXP2) in KRAS-wild-type ...
Ekin Çelik, Ertan Kanbur, Cem Bayram, Çağrı Aydoğan, Miraç Berkay Köksal, Selahattin Ata Aydın, Yiğit Emre Kurt   +6 more
doaj   +2 more sources