hsa_circ_0008305 facilitates the malignant progression of hepatocellular carcinoma by regulating AKR1C3 expression and sponging miR-379-5p [PDF]
Scientific ReportsCircular RNAs (circRNAs) are widely involved in diverse biological processes of cancers. Nonetheless, the potential function of hsa_circ_0008305 in hepatocellular carcinoma (HCC) remains largely unknown.
Shenglan Huang +5 more
doaj +4 more sources
Expression Analysis of miR-519a-3p and miR-379-5p in Colorectal Cancer Patients: A Combined Experimental and Bioinformatic Approach [PDF]
DiagnosticsBackground/Objectives: Colorectal cancer (CRC) is one of the most common malignancies worldwide. microRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression post-transcriptionally and have emerged as important regulators in cancer
Turkan Gurer +3 more
doaj +4 more sources
MiR-379-5p Promotes Chondrocyte Proliferation via Inhibition of PI3K/Akt Pathway by Targeting YBX1 in Osteoarthritis [PDF]
Cartilage, 2022 Objective We evaluated the ability of miR-379-5p to influence the proliferation of osteoarthritis chondrocytes and elucidated the regulatory mechanism of miR-379-5p in osteoarthritis. Methods Real time polymerase chain reaction (RT- PCR) was used to detect the expression of miR-379-5p and YBX1 in knee articular cartilages of human.
Jia Zheng
exaly +5 more sources
Blocking hsa_circ_0074027 suppressed non-small cell lung cancer chemoresistance via the miR-379-5p/IGF1 axis [PDF]
Bioengineered, 2021 Cancer cell chemoresistance is the primary reason behind cancer treatment failure. Previous reports suggest that circular RNA (circRNA) hsa_circ_0074027 (HC0074027) is a crucial modulator of non-small cell lung cancer (NSCLC) disease progression. Herein, we delineated the underlying mechanism of HC0074027-regulated chemoresistance in NSCLC. We employed
Yuejun Du
exaly +5 more sources
LINC00665/miR-379-5p/GRP78 regulates cisplatin sensitivity in gastric cancer by modulating endoplasmic reticulum stress [PDF]
Cytotechnology, 2021 Acquired resistance to cisplatin (DDP)-based chemotherapy greatly hinders the treatment of gastric cancer (GC). LINC00665 serves as an oncogene in GC. Hence, the current study was designed to investigate the regulatory effects of LINC00665 on DDP-resistance of GC.
Lin Xu
exaly +4 more sources
Extracellular Vesicles and Their miRNA Content in Amniotic and Tracheal Fluids of Fetuses with Severe Congenital Diaphragmatic Hernia Undergoing Fetal Intervention [PDF]
Cells, 2021 Infants with congenital diaphragmatic hernia (CDH) are at high risk of postnatal mortality due to lung hypoplasia and arterial pulmonary hypertension.
Isabella Fabietti +10 more
doaj +3 more sources
Small RNA Sequencing Uncovers New miRNAs and moRNAs Differentially Expressed in Normal and Primary Myelofibrosis CD34+ Cells. [PDF]
PLoS ONE, 2015 Myeloproliferative neoplasms (MPN) are chronic myeloid cancers thought to arise at the level of CD34+ hematopoietic stem/progenitor cells. They include essential thrombocythemia (ET), polycythemia vera (PV) and primary myelofibrosis (PMF).
Paola Guglielmelli +6 more
doaj +6 more sources
MIR-379-5p Expression in Endometrial Cancer and Its Correlation with ROR1 Expression. [PDF]
Asian Pac J Cancer Prev, 2023 To asses miR-379-5p expression in endometrial cancer (EC) and its correlation with ROR1 expression and to investigate the relation between miR-379-5p and ROR1 expressions and the clinicopathological picture of EC.Fifty female of EC were joined to this study.
Mosaad H +6 more
europepmc +3 more sources
Gazi Medical JournalObjective: To develop an optimized polyethylenimine (PEI)-based nanocarrier for the intracellular delivery of miR-379-5p and to evaluate its efficacy in suppressing the oncogenic targets metadherin (MTDH) and Forkhead box P2 (FOXP2) in KRAS-wild-type ...
Ekin Çelik +6 more
doaj +2 more sources
Linchuang shenzangbing zazhi, 2022 ObjectiveTo explore the effect of chikusetsu saponin Ⅳa （CHS） on high glucose-induced human renal tubular epithelial cells （HK-2） injury and examine whether or not its mechanism is correlated with the regulation of circEIF4G2 and miR-379-5p expression ...
Qin Li +3 more
doaj +1 more source