Results 11 to 20 of about 319,465 (163)

Memory-promoting function of miR-379-5p attenuates CD8+ T cell exhaustion by targeting immune checkpoints [PDF]

Journal for ImmunoTherapy of Cancer
Background MicroRNAs (miRNAs) are epigenetic regulators of T cell maturation and exhaustion. However, the mechanisms by which miRNAs influence T cell function in tumor environments remain unclear.
Chia-Hsin Liu, Hong-Wei Li, Liang-Chih Liu, You-Zhe Lin, Wan-Rong Wu, Ting-Yi Liao, Chuan-Chun Lee, Feng-Chi Chung, Yi-Chun Shen, Guan-Yu Zhuo, Wei-Chung Cheng, Shao-Chun Wang   +11 more
doaj   +3 more sources

Expression Analysis of miR-519a-3p and miR-379-5p in Colorectal Cancer Patients: A Combined Experimental and Bioinformatic Approach [PDF]

Diagnostics
Background/Objectives: Colorectal cancer (CRC) is one of the most common malignancies worldwide. microRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression post-transcriptionally and have emerged as important regulators in cancer
Turkan Gurer, Mehmet Emin Kizakoglu, Alper Aytekin, Rusen Avsar   +3 more
doaj   +3 more sources

hsa_circ_0008305 facilitates the malignant progression of hepatocellular carcinoma by regulating AKR1C3 expression and sponging miR-379-5p [PDF]

Scientific Reports
Circular RNAs (circRNAs) are widely involved in diverse biological processes of cancers. Nonetheless, the potential function of hsa_circ_0008305 in hepatocellular carcinoma (HCC) remains largely unknown.
Shenglan Huang, Kan Liu, Yongkan Xu, Hua Wang, Shumin Fu, Jianbing Wu   +5 more
doaj   +3 more sources

MiR-379-5p aggravates experimental autoimmune uveitis in mice via the regulation of SEMA3A

Autoimmunity, 2021
Uveitis is a disease resulting in the inflammation of uveal tracts, but the factors resulting in uveitis is still obscure. Previous studies have shown that miR-379-5p was involved in the pathogenesis of several diseases, however, the role and regulatory ...
Mohan Li, Xiang Gao, Kou Liu, Ning Bao, Zhengxuan Jiang   +4 more
doaj   +2 more sources

The miR-15b-5p/miR-379-3p-FOXO axis regulates cell cycle and apoptosis in scleral remodeling during experimental myopia

Journal of Translational Medicine
Background Myopia is one of the most common eye diseases in children and adolescents worldwide, and scleral remodeling plays a role in myopia progression.
Ruixue Zhang, Ying Wen, Jinpeng Liu, Jiawen Hao, Yuan Peng, Miao Zhang, Yunxiao Xie, Zhaohui Yang, Xuewei Yin, Yongwei Shi, Hongsheng Bi, Dadong Guo   +11 more
doaj   +2 more sources

The Effect of miR-34a-5p and miR-145-5p Ectopic Expression on Cell Proliferation and Target Gene Expression in the MDA-MB-231 Cell Line [PDF]

, 2021
Aim:It was aimed to investigate the effect of miR-34a-5p and miR-145-5p on breast cancer cell line MDA-MB-231 and to determine the expression of target genes of these microRNAs (miRNAs).Materials and Methods:Firstly, literature search and in silico ...
Emre ÖZGÜR, Kaya, Murat, İlknur SUER, Özgür, Emre, Murat KAYA, Suer, İlknur   +5 more
core   +1 more source

mir-374-5p, mir-379-5p, and mir-503-5p Regulate Proliferation and Hypertrophic Differentiation of Growth Plate Chondrocytes in Male Rats.

Endocrinology, 2018
Growth plate chondrocytes undergo sequential differentiation to form the resting (RZ), proliferative (PZ), and hypertrophic zones (HZ). The important role of microRNAs (miRNAs) in the growth plate was previously revealed by cartilage-specific ablation of
Jee YH, Wang J, Yue S, Jennings M, Clokie SJ, Nilsson O, Lui JC, Baron J.   +7 more
europepmc   +2 more sources

From Gut to Fat: Intestinal Epithelial Exosomes Target PDGFRα⁺ Progenitors to Promote Lipogenesis and Counteract Subcutaneous Adipose Tissue Atrophy in Aging. [PDF]

Aging Cell
Young small intestinal epithelial‐derived exosomes (young‐SI‐Exos) deliver miR‐379‐5p, which targets Usp34 to suppress the Wnt/β‐catenin pathway, thereby promoting adipocyte differentiation, enhancing lipid metabolism, and increasing lipid droplets in PDGFRα+ progenitors, ultimately reversing age‐related subcutaneous adipose tissue (SAT) atrophy ...
Huang T, Huang Y, Zhou Y, Lu X, Yang L, Yu J, Sheng Y, Xia F, Ding G, Lv Y, Lv S.   +10 more
europepmc   +2 more sources

MicroRNA‐379‐5p targets MAP3K2 to reduce autophagy and alleviate neuronal injury following cerebral ischemia via the JNK/c‐Jun signaling pathway

Kaohsiung Journal of Medical Sciences, 2022
MicroRNAs (miRNAs) are abundant in neurons and play key roles in the function and development of the nervous system. This study focuses on the function of miR‐379‐5p in neurological function recovery during ischemic stroke.
Yun Mo, Yin‐Yi Sun, Erli Yue, Yuan Liu, Kang‐Yong Liu   +4 more
doaj   +1 more source

MicroRNA-379-5p regulates free cholesterol accumulation and relieves diet induced-liver damage in db/db mice via STAT1/HMGCS1 axis

Molecular Biomedicine, 2022
Lipotoxicity induced by the overload of lipid in the liver, especially excess free cholesterol (FC), has been recognized as one of driving factors in the transition from non-alcoholic fatty liver (NAFL) to non-alcoholic steatohepatitis (NASH).
Yunxia Dong, Chuwei Yu, Ningning Ma, Xiaoding Xu, Qian Wu, Henglei Lu, Likun Gong, Jing Chen, Jin Ren   +8 more
doaj   +1 more source