Molecular Signature of Aluminum Hydroxide Adjuvant in Ovine PBMCs by Integrated mRNA and microRNA Transcriptome Sequencing [PDF]
, 2018 There have been few in vivo studies on the effect of aluminum hydroxide adjuvant and its influence on the immune response to vaccination. In this study, lambs received a parallel subcutaneous treatment with either commercial vaccines containing aluminum ...
Abendaño Carbajo, Naiara +8 more
core +9 more sources
Could the Anti-Chaperone VER155008 Replace Temozolomide for Glioma Treatment [PDF]
, 2015 Cancer inducible molecular chaperone HSP90 is of great importance as an anticancer target. Proteomic analysis showed that inhibiting HSP90 by the geldanamycin derivative, 17-AAG elevated the expression of the co-chaperone Hsp70.
Patil, Harshada Shashikant +2 more
core +1 more source
mir-374-5p, mir-379-5p, and mir-503-5p Regulate Proliferation and Hypertrophic Differentiation of Growth Plate Chondrocytes in Male Rats. [PDF]
Endocrinology, 2018 Growth plate chondrocytes undergo sequential differentiation to form the resting zone, the proliferative zone (PZ), and the hypertrophic zone (HZ). The important role of microRNAs (miRNAs) in the growth plate was previously revealed by cartilage-specific ablation of Dicer, an enzyme essential for biogenesis of many miRNAs.
Jee YH +7 more
europepmc +4 more sources
Altered microRNA and target gene expression related to Tetralogy of Fallot [PDF]
, 2019 MicroRNAs (miRNAs) play an important role in guiding development and maintaining function of the human heart. Dysregulation of miRNAs has been linked to various congenital heart diseases including Tetralogy of Fallot (TOF), which represents the most ...
Appelt, Sandra +4 more
core +2 more sources
Altered microRNA profile during fracture healing in rats with diabetes
Journal of Orthopaedic Surgery and Research, 2020 Background MicroRNAs (miRNAs) are a class of small non-coding RNA molecules that regulate gene expression. There is increasing evidence that some miRNAs are involved in the pathology of diabetes mellitus (DM) and its complications.
Shunsuke Takahara +11 more
doaj +1 more source
Pro-fibrotic and apoptotic activities of circARAP1 in myocardial ischemia–reperfusion injury
European Journal of Medical Research, 2023 Reperfusion modality can cause damage to cardiomyocytes, known as myocardial ischemia–reperfusion injury (MI/RI). Circular RNAs (circRNAs) are fundamental regulators associated with many cardiac diseases, including MI/RI. However, their functional impact
Xi Li, Lei Guo, Jingjing Wang, Xing Yang
doaj +1 more source
Exploring a role for regulatory miRNAs in wound healing during ageing: involvement of miR-200c in wound repair [PDF]
, 2017 YesMultiple factors and conditions can lead to impaired wound healing. Chronic non-healing wounds are a common problem among the elderly. To identify microRNAs negatively impacting the wound repair, global miRNA profiling of wounds collected from young
Ahmed, Mohammed I. +4 more
core +1 more source
Functional Roles and Biological Mechanisms of Circular RNAs and Their Encoded Peptides in Glioma: A Narrative Review [PDF]
, 2021 Circular RNAs (circRNAs) are a complicated class of non-coding RNAs that have a covalently closed loop structure and are very stable and cautious. Multiple biological processes of malignancy, including tumorigenesis, development, invasion, metastasis ...
Bakhti, Seyedeh Zahra +3 more
core +2 more sources
Evaluating the expression of miRNAs in the culture medium of human embryos with normal sex chromosomes and embryos with an X sex chromosome (Turner syndrome) [PDF]
Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām, 2023 Introduction: Assisted reproductive techniques and Preimplantation Genetic Test (PGT) are performed to detect aneuploidy to achieve a euploid baby's birth in infertile or low-fertility couples.
Shahrzad Aghajani +3 more
doaj
microRNAs profiling of small extracellular vesicles from midbrain tissue of Parkinson’s disease
Frontiers in Molecular Neuroscience, 2023 Small extracellular vesicles (sEVs) are generated by all types of cells during physiological or pathological conditions. There is growing interest in tissue-derived small extracellular vesicles (tdsEVs) because they can be isolated from a single tissue ...
Zhengzhe Li +12 more
doaj +1 more source