Results 41 to 50 of about 4,048 (141)

Identification of miRNA biomarkers for stomach adenocarcinoma

BMC Bioinformatics, 2022
Background Stomach adenocarcinoma (STAD) is a common malignant tumor in the world and its prognosis is poor, miRNA plays a role mainly by influencing the expression of mRNAs, and participates in the occurrence and development of tumors. However, reliable
Hao Qian, Nanxue Cui, Qiao Zhou, Shihai Zhang   +3 more
doaj   +1 more source

MicroRNA Signatures in Cartilage Ageing and Osteoarthritis

Biomedicines, 2023
Osteoarthritis is the most common degenerative joint disorder. MicroRNAs are gene expression regulators that act post-transcriptionally to control tissue homeostasis.
Panagiotis Balaskas, Katarzyna Goljanek-Whysall, Peter D. Clegg, Yongxiang Fang, Andy Cremers, Aibek Smagul, Tim J. M. Welting, Mandy J. Peffers   +7 more
doaj   +1 more source

First Detailed Record of Jikradia olitoria (Hemiptera: Cicadellidae) in the Swiss Southern Alps and Evaluation of Its Current Potential as a Vector of 16SrV‐Phytoplasmas

Journal of Applied Entomology, EarlyView.
ABSTRACT Jikradia olitoria Say is a Nearctic leafhopper that was recently reported in several European countries. Given its role as the vector of phytoplasmas associated with Grapevine Yellows diseases (GYD) in its native range, its presence in European vineyard agroecosystems could represent an important phytosanitary risk.
Alan Oggier, Christophe Debonneville, Marco Conedera, Attilio Rizzoli   +3 more
wiley   +1 more source

Androgen-induced exosomal miR-379-5p release determines granulosa cell fate: The cellular mechanism of anovulatory polycystic ovaries

, 2023
Abstract Polycystic ovarian syndrome (PCOS) is a complex multi-factorial syndrome associated with androgen excess and anovulatory infertility. In the current study, we investigated the role of dihydrotestosterone-induced exosomal miR-379-5p release in determining the destiny of the developing follicles.
Reza Salehi, Brandon A. Wyse, Meshach Asare-Werehene, Fereshteh Esfandiarinezhad, Atefeh Abedini, Bo Pan, Yoko Urata, Alex Gutsol, Jose L. Vinas, Sahar Jahangiri, Kai Xue, Yunping Xue, Kevin D. Burns, Barbara Vanderhyden, Julang Li, Yutaka Osuga, Dylan Burger, Seang-Lin Tan, Clifford L. Librach, Benjamin K. Tsang   +19 more
openaire   +1 more source

Exosomal miRNA-223-3p derived from tumor associated macrophages promotes pulmonary metastasis of breast cancer 4T1 cells

Translational Oncology, 2023
Research about the effect of exosomes derived from tumor associated macrophages (TAM-exos) in the distant organ metastasis of breast cancer is limited. In this study, we found that TAM-exos could promote the migration of 4T1 cells.
Ziyuan Wang, Chen Zhang, Jian Guo, Wei Wang, Qin Si, Chong Chen, Yunping Luo, Zhaojun Duan   +7 more
doaj   +1 more source

Understanding of Molecular Mechanisms and Breeding Strategies for Enhancing Oleic Acid Biosynthesis in Oil Crops

Food Frontiers, Volume 7, Issue 4, July 2026.
ABSTRACT Oleic acid (C18:1), a monounsaturated fatty acid, is a key determinant of nutritional value and oxidative stability of vegetable oils. Increasing its concentration has therefore become a central objective in oilseed crop improvement. This review summarizes current knowledge on the molecular mechanisms and breeding strategies underlying oleic ...
Muhammad Jawad Umer, Yuanxiao Zhu, Qing Lu, Hao Liu, Shaoxiong Li, Haifen Li, Runfeng Wang, Qianxia Yu, Yanbin Hong, Xuanqiang Liang, Lu Huang, Shengchun Zhang, Xiaoping Chen   +12 more
wiley   +1 more source

MicroRNA-379-5p/YBX1 Axis Regulates Cellular EMT to Suppress Migration and Invasion of Nasopharyngeal Carcinoma Cells

Cancer Management and Research, 2020
Fei Zhang,1 Chuanxin Duan,1 Shucheng Yin,2 Ying Tian1 1Department of Otolaryngology, Maternal and Child Health Care Hospital of Hubei Province and Women and Children’s Hospital of Hubei Province, Wuhan 430070, People’s Republic of China ...
Zhang F, Duan C, Yin S, Tian Y
doaj  

Osteoarthritis: Epidemiology, Diagnosis, and Treatment

MedComm, Volume 7, Issue 7, July 2026.
Osteoarthritis (OA) is a multifactorial degenerative joint disease and a leading cause of disability worldwide. This graphical abstract summarizes the epidemiology, diagnostic strategies, and therapeutic approaches of OA. OA development is driven by aging, metabolic dysregulation, and mechanical stress, leading to progressive joint degeneration ...
Qin Ru, Dongliang Yuan, Shide Jiang, Xiaoxuan Zhao, Xu Liu, Yusheng Li, Shuguang Liu, Yuxiang Wu   +7 more
wiley   +1 more source

Diagnostic and prognostic potential of eight whole blood microRNAs for equine sarcoid disease.

PLoS ONE, 2021
MicroRNAs have been proposed as biomarkers for equine sarcoids, the most prevalent equine skin tumors globally. This study served to validate the diagnostic and prognostic potential of whole blood microRNAs identified in a previous study for long-term ...
Jeanne Cosandey, Eman Hamza, Vinzenz Gerber, Alessandra Ramseyer, Tosso Leeb, Vidhya Jagannathan, Klaudia Blaszczyk, Lucia Unger   +7 more
doaj   +1 more source

From Gut to Fat: Intestinal Epithelial Exosomes Target PDGFRα+ Progenitors to Promote Lipogenesis and Counteract Subcutaneous Adipose Tissue Atrophy in Aging

Aging Cell, Volume 25, Issue 7, July 2026.
Young small intestinal epithelial‐derived exosomes (young‐SI‐Exos) deliver miR‐379‐5p, which targets Usp34 to suppress the Wnt/β‐catenin pathway, thereby promoting adipocyte differentiation, enhancing lipid metabolism, and increasing lipid droplets in PDGFRα+ progenitors, ultimately reversing age‐related subcutaneous adipose tissue (SAT) atrophy ...
Tingting Huang, Ye Huang, Yin Zhou, Xuanbei Lu, Lijun Yang, Jing Yu, Yunlu Sheng, Fan Xia, Guoxian Ding, Yifan Lv, Shan Lv   +10 more
wiley   +1 more source