Altered microRNA profile during fracture healing in rats with diabetes
Journal of Orthopaedic Surgery and Research, 2020 Background MicroRNAs (miRNAs) are a class of small non-coding RNA molecules that regulate gene expression. There is increasing evidence that some miRNAs are involved in the pathology of diabetes mellitus (DM) and its complications.
Shunsuke Takahara +11 more
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Pro-fibrotic and apoptotic activities of circARAP1 in myocardial ischemia–reperfusion injury
European Journal of Medical Research, 2023 Reperfusion modality can cause damage to cardiomyocytes, known as myocardial ischemia–reperfusion injury (MI/RI). Circular RNAs (circRNAs) are fundamental regulators associated with many cardiac diseases, including MI/RI. However, their functional impact
Xi Li, Lei Guo, Jingjing Wang, Xing Yang
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Evaluating the expression of miRNAs in the culture medium of human embryos with normal sex chromosomes and embryos with an X sex chromosome (Turner syndrome) [PDF]
Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām, 2023 Introduction: Assisted reproductive techniques and Preimplantation Genetic Test (PGT) are performed to detect aneuploidy to achieve a euploid baby's birth in infertile or low-fertility couples.
Shahrzad Aghajani +3 more
doaj
microRNAs profiling of small extracellular vesicles from midbrain tissue of Parkinson’s disease
Frontiers in Molecular Neuroscience, 2023 Small extracellular vesicles (sEVs) are generated by all types of cells during physiological or pathological conditions. There is growing interest in tissue-derived small extracellular vesicles (tdsEVs) because they can be isolated from a single tissue ...
Zhengzhe Li +12 more
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miR-149-5p mitigates tumor necrosis factor-α-induced chondrocyte apoptosis by inhibiting TRADD [PDF]
, 2020 Introduction Chondrocyte apoptosis as a prominent characteristic is usually accompanied by cartilage degeneration in osteoarthritis (OA). Herein, we aimed to determine the roles of miR-149-5p in tumor necrosis factor-α (TNF-α)-induced chondrocyte ...
Shi-cheng Xie +4 more
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miR-34a-5p affects the EZH2 protein pathway. [PDF]
, 2023 (A) Binding sites of EZH2 and miR-34a-5p were predicted through bioinformatics analysis. (BⅠ-Ⅱ) Double luciferase reporter experiment confirmed this prediction.
Chengcheng Liao (12402943) +16 more
core +1 more source
Bioinformatics predicted oar-miR-3955-5p binding sites on XLOC005698, and oar-miR-544-5p binding sites on XLOC000629. [PDF]
, 2016 (a) Alignment between XLOC005698 and oar-miR-3955-5p as well as between XLOC000629 and oar-miR-544-5p. (b) The oar-miR-3955-5p miRNA binding sites on XLOC005698. (c)The oar-miR-544-5p miRNA binding sites on XLOC000629.
Tingting Guo (101831) +8 more
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TGIF2 expression in miR-210-5p-overexpressing cells. [PDF]
, 2021 (A) Predicted miR-210-5p binding sites in the TGIF2-3`UTR. (B) HOS cells were transfected with the luciferase reporter vector of TGIF2-3`UTR (upper image) and various amounts of miR-210-5p mimic, and dual-luciferase activity was measured 30 h later. (C-D)
Lixia Huang (429197) +9 more
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Coordinated Expressional Landscape of the Human Placental miRNome and Transcriptome
Frontiers in Cell and Developmental Biology, 2021 Placenta is a unique organ that serves its own function, and contributes to maternal gestational adaptation and fetal development. Coordination of its transcriptome to satisfy all the maternal-fetal needs across gestation is not fully understood ...
Rain Inno +3 more
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miR-218-5p directly targets HMGB2 and CMPK1 3'UTR. [PDF]
, 2019 (A). Luciferase activity in HEK293T cells cotransfected with miR-218-5p mimic (miR-218-5p; 10 nM) or its control (NC of mimic; 10 nM) and the reporter constructs for 48 h. (B). Luciferase activity in HEK293T cells cotransfected with increasing amounts of
Qin Yan (281622) +6 more
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