Infected erythrocyte-derived extracellular vesicles alter vascular function via regulatory Ago2-miRNA complexes in malaria [PDF]
, 2016 Malaria remains one of the greatest public health challenges worldwide, particularly in sub-Saharan Africa. The clinical outcome of individuals infected with Plasmodium falciparum parasites depends on many factors including host systemic inflammatory ...
A Bhoumik +64 more
core +1 more source
Regulation of microRNA during cardiomyocyte maturation in sheep. [PDF]
, 2015 BACKGROUND: There is a limited capacity to repair damage in the mammalian heart after birth, which is primarily due to the inability of cardiomyocytes to proliferate after birth.
Botting, Kimberley J +6 more
core +2 more sources
To Detach, Migrate, Adhere, and Metastasize: CD97/ADGRE5 in Cancer [PDF]
, 2022 Tumorigenesis is a multistep process, during which cells acquire a series of mutations that lead to unrestrained cell growth and proliferation, inhibition of cell differentiation, and evasion of cell death.
Aust, Gabriela +2 more
core +2 more sources
Coordinated Expressional Landscape of the Human Placental miRNome and Transcriptome
Frontiers in Cell and Developmental Biology, 2021 Placenta is a unique organ that serves its own function, and contributes to maternal gestational adaptation and fetal development. Coordination of its transcriptome to satisfy all the maternal-fetal needs across gestation is not fully understood ...
Rain Inno +3 more
doaj +1 more source
Expression profile of the chromosome 14 Microrna Cluster (C14MC) ortholog in equine maternal circulation throughout pregnancy and its potential implications [PDF]
, 2019 Equine chromosome 24 microRNA cluster (C24MC), the ortholog of human C14MC, is a pregnancy-related miRNA cluster. This cluster is believed to be implicated in embryonic, fetal, and placental development.
A. Ball, Barry +7 more
core +1 more source
Identification of miRNA biomarkers for stomach adenocarcinoma
BMC Bioinformatics, 2022 Background Stomach adenocarcinoma (STAD) is a common malignant tumor in the world and its prognosis is poor, miRNA plays a role mainly by influencing the expression of mRNAs, and participates in the occurrence and development of tumors. However, reliable
Hao Qian +3 more
doaj +1 more source
MicroRNA Signatures in Cartilage Ageing and Osteoarthritis
Biomedicines, 2023 Osteoarthritis is the most common degenerative joint disorder. MicroRNAs are gene expression regulators that act post-transcriptionally to control tissue homeostasis.
Panagiotis Balaskas +7 more
doaj +1 more source
Cholesterol metabolism is a potential therapeutic target in Duchenne muscular dystrophy [PDF]
, 2021 Background: Duchenne muscular dystrophy (DMD) is a lethal muscle disease detected in approximately 1:5000 male births. DMD is caused by mutations in the DMD gene, encoding a critical protein that links the cytoskeleton and the extracellular matrix in ...
Amor, F +9 more
core
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Translational Oncology, 2023 Research about the effect of exosomes derived from tumor associated macrophages (TAM-exos) in the distant organ metastasis of breast cancer is limited. In this study, we found that TAM-exos could promote the migration of 4T1 cells.
Ziyuan Wang +7 more
doaj +1 more source