Results 71 to 80 of about 248,159 (173)

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, Volume 13, Issue 35, 24 June 2026.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Reduced levels of methyltransferase DNMT2 sensitize human fibroblasts to oxidative stress and DNA damage that is accompanied by changes in proliferation-related miRNA expression

Redox Biology, 2018
Methyltransferase DNMT2 is suggested to be involved in the regulation of numerous processes, however its biological significance and underlying molecular mechanisms remain elusive.
Anna Lewinska, Jagoda Adamczyk-Grochala, Ewa Kwasniewicz, Anna Deregowska, Ewelina Semik, Tomasz Zabek, Maciej Wnuk   +6 more
doaj   +1 more source

MiR-515-5p was a direct target of hsa_circ_0056686. [PDF]

, 2022
(A) The sequences of hsa_circ_0056686 containing the miR-515-5p binding sites or mutant binding sites were showed. (B) (n = 30) Relative miR-515-5p expression level in ULM tissues and normal myometrial tissues.
Dongfang Guo (1298073), Meifang Suo (12368512), Airong Zhang (745854), Zhichen Lin (4437625)   +3 more
core   +1 more source

Establishment of Repertoire of Placentome-Associated MicroRNAs and Their Appearance in Blood Plasma Could Identify Early Establishment of Pregnancy in Buffalo (Bubalus bubalis)

Frontiers in Cell and Developmental Biology, 2021
Precise early pregnancy diagnosis in dairy animals is of utmost importance for an efficient dairy production system. Not detecting a dairy animal pregnant sufficiently early after the breeding results to extending the unproductive time of their milk ...
Parul Sarwalia, Mustafa Raza, Apoorva Soni, Pratiksha Dubey, Pratiksha Dubey, Rajeev Chandel, Rakesh Kumar, A. Kumaresan, Suneel Kumar Onteru, Ankit Pal, Kalpana Singh, Mir Asif Iquebal, Sarika Jaiswal, Dinesh Kumar, T. K. Datta   +14 more
doaj   +1 more source

The miR-590 C57T SNP reduces levels of miR-590-5p and miR-590-3p, without affecting the levels of pri-miR-590 and pre-miR-590. [PDF]

, 2016
(A) Quantification of pri-miR-590 by qRT-PCR normalized by GAPDH. Mean ± SD (n = 3). HEK293T cells were transfected with the pri-miR-590-WT or pri-miR-590-SNP plasmids. The empty plasmid was used as negative control.
Suresh K. Kandasamy (2794198), Steven Steinberg (582816), Scot J. Matkovich (421129), Neal Epstein (2794180), Dotti Tripodi (2794204), Garry Cutting (2794201), Xiaoping Lin (215407), Blaid Mbiyangandu (2794195), Celia P. Corona-Villalobos (2794189), Ryuya Fukunaga (2794186), M. Roselle Abraham (242563), Junaid Afzal (2794192), Susan E. Liao (2794177), Yufan Guan (2794171), Zhaoxia Huo (2794183), Theodore P. Abraham (2794174)   +15 more
core   +1 more source

Vascular Calcification: Mechanisms, Models, and Therapies

iNew Medicine, Volume 2, Issue 2, June 2026.
ABSTRACT Vascular calcification represents an active multifactorial process that mirrors several key features of skeletal bone mineralization. Clinically, it is characterized by diminished arterial compliance and increased arterial wall stiffness, both of which serve as independent predictors of significant adverse cardiovascular events.
Wenya Zhu, Shu Yang, Ziyi Chen, Xiaoxiao Yang, Zhen Liang, Yuanli Chen   +5 more
wiley   +1 more source

miR-125a-5p suppresses colorectal cancer progression by targeting VEGFA [PDF]

, 2018
Xuehua Yang, Jianwei Qiu, Haifeng Kang, Yaming Wang, Junbo Qian Department of Gastroenterology, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu, China Background: MiR-125a-5p has been reported to be involved in the development and
Yang X, Qiu J, Kang H, Qian J, Wang Y
core  

MicroRNA-379-5p attenuates cancer stem cells and reduces cisplatin resistance in ovarian cancer by regulating RAD18/Polη axis

Cell Death and Disease
Ovarian cancer (OC) is an aggressive malignancy of the female reproductive organs, associated with a low 5-year survival rate. Emerging evidence suggests the pivotal role of microRNAs (miRNAs) in regulating chemoresistance and metastasis in OC, primarily
Devendra Shukla, Sanjay Mishra, Tanima Mandal, Manish Charan, Ajeet Kumar Verma, Md Maqsood Ahamad Khan, Nabanita Chatterjee, Amit Kumar Dixit, Senthil Kumar Ganesan, Ramesh K. Ganju, Amit Kumar Srivastava   +10 more
doaj   +1 more source

MOV10 binding circ-DICER1 regulates the angiogenesis of glioma via miR-103a-3p/miR-382-5p mediated ZIC4 expression change

Journal of Experimental & Clinical Cancer Research, 2019
Background RNA binding proteins (RBPs) have been reported to interact with RNAs to regulate gene expression. Circular RNAs (circRNAs) are a type of endogenous non-coding RNAs, which involved in the angiogenesis of tumor.
Qianru He, Lini Zhao, Xiaobai Liu, Jian Zheng, Yunhui Liu, Libo Liu, Jun Ma, Heng Cai, Zhen Li, Yixue Xue   +9 more
doaj   +1 more source

Small RNA Sequencing Uncovers New miRNAs and moRNAs Differentially Expressed in Normal and Primary Myelofibrosis CD34+ Cells. [PDF]

PLoS ONE, 2015
Myeloproliferative neoplasms (MPN) are chronic myeloid cancers thought to arise at the level of CD34+ hematopoietic stem/progenitor cells. They include essential thrombocythemia (ET), polycythemia vera (PV) and primary myelofibrosis (PMF).
Paola Guglielmelli, Andrea Bisognin, Claudia Saccoman, Carmela Mannarelli, Alessandro Coppe, Alessandro M Vannucchi, Stefania Bortoluzzi   +6 more
doaj   +1 more source