Results 71 to 80 of about 4,048 (141)

Aging‐Driven Immunosuppression: The Role of Tregs in the Ovarian Tumor Microenvironment

Aging Cell, Volume 25, Issue 5, May 2026.
In the aged ovarian TME, cancer cells exhibit increased succinate production. Elevated extracellular succinate activates the SUCNR1 receptor on Tregs, promoting their recruitment and contributing to an immunosuppressive environment. This leads to diminished anti‐tumor T cell responses and reduced survival.
Mary P. Udumula, Anjaly KM, Faraz Rashid, Mohammad Nematullah, Harshit Singh, Tanya Bhardwaj, Miriana Hijaz, Shailendra Giri, Eduardo N. Chini, Heather M. Gibson, Ramandeep Rattan   +10 more
wiley   +1 more source

Small and Large Extracellular Vesicles in Circulation of Diffuse Large B‐Cell Lymphoma Patients Originate From Different Cell Types of the Tumor Microenvironment

Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
ABSTRACT Malignant and non‐malignant cells within the tumor microenvironment (TME) actively secrete extracellular vesicles (EVs) that may mediate intercellular communication or enter the blood stream. Circulating EVs in Diffuse Large B‐Cell Lymphoma (DLBCL) patients are a promising source of liquid biopsy biomarkers; however, whether different cellular
Filippo Maltoni, Steven Wang, Mischa. F. B. Steketee, Cristina A. Gómez‐Martín, Esther E. E. Drees, Federica Morelli, Leontien Bosch, Monique van Eijndhoven, Gert Jan Timmers, Ilse Houtenbos, Josée M. Zijlstra, Xiaofei Ye, Qiang Pan‐Hammarström, Martine E. D. Chamuleau, Pier Luigi Zinzani, Yongsoo Kim, Lucia Catani, Dirk Michiel Pegtel   +17 more
wiley   +1 more source

The Homeobox Genes: Classification, Regulation, Biological Functions, and Diseases

MedComm, Volume 7, Issue 4, April 2026.
Overview of the homeobox gene superfamily and its pathophysiological roles. The homeobox superfamily comprises several major classes, including ANTP, PRD, TALE, LIM, POU, and others. Among these, the HOX clusters (A–D) play critical roles in embryonic development specifically in conferring cellular identity, regulating morphogenesis, and guiding axial ...
Maedeh Dadzadi, Shahin Ramazi, Mona Darvazi, Sepideh Yoosefi, Melika Abbasi, Shirin Farsad   +5 more
wiley   +1 more source

Osteoarthritis: Epidemiology, Pathogenesis, and Treatment

MedComm, Volume 7, Issue 4, April 2026.
Osteoarthritis is a prevalent degenerative joint disease with a growing global burden. Its development involves complex interactions among epidemiological factors, pathological changes, molecular signaling, and epigenetic regulation. Understanding these mechanisms provides insights into disease progression and supports the development of therapeutic ...
Tianrui Chen, Wenlong Chen, Tianpeng Xu, Hong Wang, Yuheng Zhang, Li Wang, Sijie Zhu, Huaqiang Tao, Xing Yang   +8 more
wiley   +1 more source

A comprehensive method for identification of suitable reference genes in extracellular vesicles

Journal of Extracellular Vesicles, 2017
Reverse transcription–quantitative polymerase chain reaction (RT-qPCR) is one of the most sensitive, economical and widely used methods for evaluating gene expression.
Kenneth Gouin, Kiel Peck, Travis Antes, Jennifer Leigh Johnson, Chang Li, Sharon Denise Vaturi, Ryan Middleton, Geoff de Couto, Ann-Sophie Walravens, Luis Rodriguez-Borlado, Rachel Ruckdeschel Smith, Linda Marbán, Eduardo Marbán, Ahmed Gamal-Eldin Ibrahim   +13 more
doaj   +1 more source

The miR-15b-5p/miR-379-3p-FOXO axis regulates cell cycle and apoptosis in scleral remodeling during experimental myopia

Journal of Translational Medicine
Background Myopia is one of the most common eye diseases in children and adolescents worldwide, and scleral remodeling plays a role in myopia progression.
Ruixue Zhang, Ying Wen, Jinpeng Liu, Jiawen Hao, Yuan Peng, Miao Zhang, Yunxiao Xie, Zhaohui Yang, Xuewei Yin, Yongwei Shi, Hongsheng Bi, Dadong Guo   +11 more
doaj   +1 more source

Sources of Individual Variability: Mirnas That Predispose to Neuropathic Pain Identified Using Genome-Wide Sequencing

Molecular Pain, 2014
Background: We carried out a genome-wide study, using microRNA sequencing (miRNA-seq), aimed at identifying miRNAs in primary sensory neurons that are associated with neuropathic pain. Such scans usually yield long lists of transcripts regulated by nerve
Kiran Kumar Bali, Michael Hackenberg, Avigail Lubin, Rohini Kuner, Marshall Devor   +4 more
doaj   +1 more source

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Role of mast cell-derived exosomes in exacerbating neuronal injury of experimental cerebral malaria

Parasites & Vectors
Background Cerebral malaria (CM), a fatal neurological complication of Plasmodium falciparum infection, is partially driven by neuronal injury. Emerging evidence highlights exosomes as vital mediators of mast cell–neuron interactions in neurological ...
Qianru Wang, Xiumei Mo, Hua Li, Mingqiu Ye, Guojun Fei, Pinru Chen, Yongfei Wang, Xinpeng Hou, Jiajing He, Wenbin Liu, Jie Wang, Hui Yin, Zujun Deng, Xiaobao Jin, Zhenlong Liu, Qi Wang, Bo Huang   +16 more
doaj   +1 more source

Publication Only

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source