Results 81 to 90 of about 4,116 (175)

Advanced extracellular vesicle immunotherapy

FlexMat, Volume 3, Issue 1, Page 117-143, March 2026.
A diagrammatic depiction of the therapeutic applicability of extracellular vesicles (EVs) in immunotherapy. This review explores the dual roles of tumor‐derived and immune cell‐derived EVs in cancer immunotherapy, discusses recent progress in EV engineering that improve their clinical utility, and evaluates their potential to augment existing ...
Jingjing Zhang, Yunfei Mu, Xianyue Ji, Xiaoting Jiang, Ruiheng Wang, Xianguang Ding, Lianhui Wang   +6 more
wiley   +1 more source

Circulating microRNAs in patients with hormone receptor-positive, metastatic breast cancer treated with dovitinib

Clinical and Translational Medicine, 2017
Background Serial analysis of biomarkers in the circulation of patients undergoing treatment (“liquid biopsies”) can provide new insights into drug effects.
Narayan Shivapurkar, Eveline E. Vietsch, Erin Carney, Claudine Isaacs, Anton Wellstein   +4 more
doaj   +1 more source

Integrated Hypothalamic Transcriptome Profiling Reveals the Reproductive Roles of mRNAs and miRNAs in Sheep

Frontiers in Genetics, 2020
Early studies have provided a wealth of information on the functions of microRNAs (miRNAs). However, less is known regarding their functions in the hypothalamus involved in sheep reproduction. To explore the potential roles of hypothalamic messenger RNAs
Zhuangbiao Zhang, Jishun Tang, Jishun Tang, Ran Di, Qiuyue Liu, Xiangyu Wang, Shangquan Gan, Xiaosheng Zhang, Jinlong Zhang, Mingxing Chu, Wenping Hu   +10 more
doaj   +1 more source

Differential expression of microRNAs in adipose tissue after long-term high-fat diet-induced obesity in mice. [PDF]

PLoS ONE, 2012
Obesity is a major health concern worldwide which is associated with increased risk of chronic diseases such as metabolic syndrome, cardiovascular disease and cancer.
Dionysios V Chartoumpekis, Apostolos Zaravinos, Panos G Ziros, Ralitsa P Iskrenova, Agathoklis I Psyrogiannis, Venetsana E Kyriazopoulou, Ioannis G Habeos   +6 more
doaj   +1 more source

RNA Regulatory Networks: Key Hubs in the Panorama of Cancer and Emerging Therapeutic Targets

MedComm, Volume 7, Issue 3, March 2026.
RNA regulatory networks play a crucial role in the initiation and progression of cancer through various modes of RNA interactions. Notably, circulating RNAs have emerged as potential biomarkers, while targeted interventions in RNA regulatory networks facilitate precise therapeutic strategies. ABSTRACT Cancer is a global health challenge. The initiation
Xuan Yin, Zengkan Du, Shuya Jiang, Yan Liao, Changli Wang, Jiaqi Li, Haoling Zhang, Ting‐Ting Wei, Wangzheqi Zhang, Zui Zou   +9 more
wiley   +1 more source

Additional file 1 of Androgen-induced exosomal miR-379-5p release determines granulosa cell fate: cellular mechanism involved in polycystic ovaries

, 2023
Additional file 1: Supplementary Figure 1. Androgen excess in human PCOS subjects is associated with reduced follicular fluid-derived exosomal mir-379-5p content and granulosa cell proliferation. (A) Follicular fluids from the dominant follicles (≥ 20 mm; n = 25 Non-PCOS and 13 PCOS subjects) of PCOS subjects exhibited significantly higher free ...
Salehi, Reza, Wyse, Brandon A., Asare-Werehene, Meshach, Esfandiarinezhad, Fereshteh, Abedini, Atefeh, Pan, Bo, Urata, Yoko, Gutsol, Alex, Vinas, Jose L., Jahangiri, Sahar, Xue, Kai, Xue, Yunping, Burns, Kevin D., Vanderhyden, Barbara, Li, Julang, Osuga, Yutaka, Burger, Dylan, Tan, Seang-Lin, Librach, Clifford L., Tsang, Benjamin K.   +19 more
openaire   +1 more source

Chromatin Accessibility in Cancer: Biological Functions, Mechanisms, Therapeutic Potential, and Future Directions

MedComm, Volume 7, Issue 3, March 2026.
Cancer remains the leading cause of mortality worldwide, and drug resistance further underscores the urgent need for innovative therapeutic strategies. Chromatin, a stable yet highly dynamic nucleoprotein complex, serves as the primary carrier of genetic material in eukaryotic cells.
Wentao Xia, Min Jiang, Yefei Huang, Kun Ding, Yansu Chen   +4 more
wiley   +1 more source

Comparison of Adult Testis and Ovary MicroRNA Expression Profiles in Reeves’ Pond Turtles (Mauremys reevesii) With Temperature-Dependent Sex Determination

Frontiers in Genetics, 2020
Some differentially expressed genes (DEGs) that encode key enzymes involved in steroidogenic biosynthesis (CYP19A1) and key molecules related to gonadal functions (DMRT1, SOX9, AMH, FOXL2, WNT4, RSPO2, and GDF9) have been identified in adult gonadal RNA ...
Lei Xiong, Lei Xiong, Mengli Yang, Kai Zheng, Ziming Wang, Shengli Gu, Shengli Gu, Jiucui Tong, Jiucui Tong, Jianjun Liu, Nadar Ali Shah, Liuwang Nie   +11 more
doaj   +1 more source

MiR-379-5p improved locomotor function recovery after spinal cord injury in rats by reducing endothelin 1 and inhibiting astrocytes expression.

European review for medical and pharmacological sciences, 2019
The aim of this study was to investigate the effect of microRNA-214-5p (miR-214-5p) on spinal cord injury (SCI) and to explore the mechanism of action in pathophysiological relevance.The model of SCI was successfully established in rats aged 6-8 weeks.
A, J.-C., Li, Z.-Y., Long, Q.-F., Wang, D.-Y., Zhao, H.-S., Jia, S.-L., Zhang, W.-H.   +6 more
openaire   +2 more sources

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, Volume 46, Issue 2, Page 475-512, March 2026.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source