Results 91 to 100 of about 248,159 (173)
Frontiers in Genetics, 2020 Some differentially expressed genes (DEGs) that encode key enzymes involved in steroidogenic biosynthesis (CYP19A1) and key molecules related to gonadal functions (DMRT1, SOX9, AMH, FOXL2, WNT4, RSPO2, and GDF9) have been identified in adult gonadal RNA ...
Lei Xiong +11 more
doaj +1 more source
ESC Heart Failure, 2021 Aims MicroRNAs (miRNAs) might be used as prospective biomarkers for the identification of unexplained heart failure caused by a viral and/or inflammatory process.
Ganna Aleshcheva +3 more
doaj +1 more source
Aging‐Driven Immunosuppression: The Role of Tregs in the Ovarian Tumor Microenvironment
Aging Cell, Volume 25, Issue 5, May 2026.In the aged ovarian TME, cancer cells exhibit increased succinate production. Elevated extracellular succinate activates the SUCNR1 receptor on Tregs, promoting their recruitment and contributing to an immunosuppressive environment. This leads to diminished anti‐tumor T cell responses and reduced survival.
Mary P. Udumula +10 more
wiley +1 more source
Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.ABSTRACT Malignant and non‐malignant cells within the tumor microenvironment (TME) actively secrete extracellular vesicles (EVs) that may mediate intercellular communication or enter the blood stream. Circulating EVs in Diffuse Large B‐Cell Lymphoma (DLBCL) patients are a promising source of liquid biopsy biomarkers; however, whether different cellular
Filippo Maltoni +17 more
wiley +1 more source
The Homeobox Genes: Classification, Regulation, Biological Functions, and Diseases
MedComm, Volume 7, Issue 4, April 2026.Overview of the homeobox gene superfamily and its pathophysiological roles. The homeobox superfamily comprises several major classes, including ANTP, PRD, TALE, LIM, POU, and others. Among these, the HOX clusters (A–D) play critical roles in embryonic development specifically in conferring cellular identity, regulating morphogenesis, and guiding axial ...
Maedeh Dadzadi +5 more
wiley +1 more source
Mir-434-5p mediates skin whitening and lightening [PDF]
, 2008 David TS Wu, Jack S Chen, Donald C Chang, Shi-Lung LinInstitute of Mello Biotechnology, Taipei, Taiwan, ROCAbstract: Utilization of gene silencing effectors, such as microRNA (miRNA) and small airpin RNA (shRNA), provides a powerful new strategy for ...
Shi-Lung Lin +3 more
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miR-16-5p Regulates Ferroptosis by Targeting SLC7A11 in Adriamycin-Induced Ferroptosis in Cardiomyocytes [PDF]
, 2023 Yongquan Chen, Yecheng Deng, Linghua Chen, Ziyao Huang, Yi Yan, Zhaoqi Huang Department of Cardiology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, People’s Republic of ChinaCorrespondence: Zhaoqi Huang, Department of ...
Huang Z, Chen L, Chen Y, Yan Y, Deng Y
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Osteoarthritis: Epidemiology, Pathogenesis, and Treatment
MedComm, Volume 7, Issue 4, April 2026.Osteoarthritis is a prevalent degenerative joint disease with a growing global burden. Its development involves complex interactions among epidemiological factors, pathological changes, molecular signaling, and epigenetic regulation. Understanding these mechanisms provides insights into disease progression and supports the development of therapeutic ...
Tianrui Chen +8 more
wiley +1 more source
miR-491-5p functions as a tumor suppressor by targeting IGF2 in colorectal cancer [PDF]
, 2019 Lei Lu,* Ming Cai,* Meixia Peng, Fei Wang, Xiaofeng Zhai Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu, China *These authors contributed equally to this work Background: Dysregulation of ...
Lu L, Cai M, Zhai X, Wang F, Peng M
core
Advanced Science, Volume 13, Issue 16, 18 March 2026.ABSTRACT Immune homeostasis is indispensable for preserving organismal integrity, orchestrated through complex molecular networks encompassing immune cell dynamics, microbial cues, and epigenetic regulation. Among these, the gut microbiota‐non‐coding RNA (ncRNA) axis has recently garnered substantial attention as a multifaceted modulator of host ...
Bonan Chen +12 more
wiley +1 more source