Role of mast cell-derived exosomes in exacerbating neuronal injury of experimental cerebral malaria
Parasites & VectorsBackground Cerebral malaria (CM), a fatal neurological complication of Plasmodium falciparum infection, is partially driven by neuronal injury. Emerging evidence highlights exosomes as vital mediators of mast cell–neuron interactions in neurological ...
Qianru Wang +16 more
doaj +1 more source
Exosomal MicroRNA Signatures in Central Nervous System Diseases [PDF]
, 2018 During the last decade there has been a growing interest in studying extracellular vesicles, in particular exosomes and their miRNA contents. Exosomes are released by almost all cell types.
Ebrahimkhani, Saeideh
core
MicroRNA binding site variants–new potential markers of primary osteoporosis in men and women [PDF]
IntroductionThe identification of significant DNA markers of primary osteoporosis may gain new insights by studying genome regions involved in mechanisms of epigenetic regulation through interactions with microRNAs.MethodsThe authors searched for ...
Anna Eremkina +9 more
core +1 more source
Ultraviolet radiation-induced tumor necrosis factor alpha, which is linked to the development of cutaneous SCC, modulates differential epidermal microRNAs expression [PDF]
, 2016 Chronic exposure to ultraviolet radiation (UVR) is linked to the development of cutaneous squamous cell carcinoma (SCC), a non-melanoma form of skin cancer that can metastasize.
Hafeez, Bilal B. +6 more
core +2 more sources
MiRNA调控脑缺血/再灌注诱导的自噬信号通路研究进展 [PDF]
脑卒中时缺血缺氧致脑组织功能损伤，且缺血后脑组织再恢复血液供应时，大量自由基、钙超载等引起脑缺血/再灌注损伤，进一步加重病情。自噬是一种维持细胞内环境稳态的自我保护机制，但过度自噬引起脑组织损伤。MiRNA为小的内源性非编码RNA分子，通过与其靶基因mRNA的3’ -UTR中的互补序列结合，导致翻译抑制或mRNA降解，从基因水平上调控多种生理活动。MiRNA不仅直接作用于自噬相关蛋白，还可通过多种信号通路，参与缺血/再灌注诱导的自噬调控。但关于miRNA调控脑缺血 ...
刘筱蔼, 罗友根
core +1 more source
MicroRNA profiling of the feline left heart identifies chamber-specific expression signatures in health and in advanced hypertrophic cardiomyopathy [PDF]
, 2023 Caswell, Jeff L +6 more
core +1 more source
CellsSpina Bifida (SB) and Congenital Diaphragmatic Hernia (CDH) are complex congenital anomalies that pose significant challenges in pediatric healthcare. This review synthesizes recent advancements in understanding the genetic, metabolic, and environmental ...
Angelika Buczyńska +4 more
doaj +1 more source
Hypomethylation of miR-142 promoter and upregulation of microRNAs that target the oxytocin receptor gene in the autism prefrontal cortex [PDF]
, 2015 core +1 more source
Hledání cirkulujících biomarkerů charakterizujících časnou axiální spondylartritidu a její progresi [PDF]
Axial spondyloarthritis (axSpA) is a chronic autoimmune disease primarily affecting the spine and sacroiliac joints. It presents with chronic back pain, sacroiliitis, arthritis, and other skeletal and extra-skeletal inflammatory symptoms.
Mocová, Klára
core
American journal of translational researchTo analyze the regulatory mechanism microRNA miR-379-5p in oral squamous cell carcinoma (OSCC).We collected serum samples from patients with OSCC and examined the expression of miR-379-5p and receptor tyrosine kinase-like orphan receptor 1 (ROR1) by real-time polymerase chain reaction and western blot.
Lei, Meng +3 more
openaire +1 more source