Results 1 to 10 of about 357,095 (308)

Preliminary evidence supports circulating microRNAs as prognostic biomarkers for type 2 diabetes. [PDF]

, 2017
Background:Circulating microRNAs are emerging as potential prognostic biomarkers for the development of type 2 diabetes. However, microRNAs are also associated with complications from impaired glucose metabolism (e.g. endothelial cell function).
Allen, IE, Aouizerat, BE, Cooper, B, Flowers, E, Fukuoka, Y, Kanaya, AM   +5 more
core   +1 more source

Circulating microRNAs Reveal Time Course of Organ Injury in a Porcine Model of Acetaminophen-Induced Acute Liver Failure [PDF]

, 2015
Acute liver failure is a rare but catastrophic condition which can progress rapidly to multi-organ failure. Studies investigating the onset of individual organ injury such as the liver, kidneys and brain during the evolution of acute liver failure, are ...
A O'Riordan, A Turchinovich, AB Imaeda, AM Larson, AM Reddy, B Ekser, Carolina Palacios Jimenez, CD Williams, CL Andersen, D Mladinov, Diego Calvisi, DJ Antoine, E Cholongitas, F Martino, Fausto Andreola, G Szabo, Hatim Alibhai, HT Zhu, J Hellemans, J Vandesompele, JG O'Grady, JK Moore, K John, K Purins, K Wang, Karla C. L. Lee, KC Lee, Lewis PJ Starkey, Luisa A. Baker, M Karali, M Lagos-Quintana, M Weiland, ML Bajt, MR McGill, MW Pfaffl, N Silver, Nathan A. Davies, O Timoneda, O Timoneda, OF Laterza, P Gilje, P Landgraf, Pamela J. Leckie, PS Mitchell, Q Ge, R Bellomo, Rajeshwar P. Mookerjee, Rajiv Jalan, RL Mehta, RT Stravitz, S Bala, T Kawai, W Bernal, WE Hoffman, WM Lee, X Chen, Y Sun, Y Wang, Y Zhang, Yu-Mei Chang, YW Kong   +60 more
core   +14 more sources

Clusters of microRNAs emerge by new hairpins in existing transcripts [PDF]

, 2013
Genetic linkage may result in the expression of multiple products from a polycistronic transcript, under the control of a single promoter. In animals, protein-coding polycistronic transcripts are rare.
Alberts, Altschul, Altuvia, Antonio Marco, Aravin, Auyeung, Axtell, Bartel, Bartel, Barton, Baskerville, Blumenthal, Blumenthal, Boutla, Campo-Paysaa, Charlesworth, Cutter, Felsenstein, Griffiths-Jones, Griffiths-Jones, Grimson, Han, Hertel, Hill, Katoh, Kim, Kloosterman, Kozomara, Krol, Lagos-Quintana, Larkin, Lau, Lawrence, Leaman, Lee, Lee, Li, Lynch, Lynch, Maher, Marco, Marco, Marco, Marco, Marco, Maria Ninova, Matthew Ronshaugen, Maynard Smith, Nozawa, Nozawa, Qian, Roux, Ruby, Ryazansky, Saini, Saini, Saitou, Salgado, Sam Griffiths-Jones, Satou, Savard, Sempere, Tamura, Tanzer, Wheeler, Wheeler, Zeng   +66 more
core   +2 more sources

Regulation of neutrophil senescence by microRNAs [PDF]

, 2011
Neutrophils are rapidly recruited to sites of tissue injury or infection, where they protect against invading pathogens. Neutrophil functions are limited by a process of neutrophil senescence, which renders the cells unable to respond to chemoattractants,
A Bonauer, A Lee, AD Kennedy, AS Cowburn, AW Ford-Hutchinson, C Haslett, C Martin, CH Wang, CL Andersen, DP Bartel, E Berezikov, E Tsitsiou, EP Cronkite, F Bazzoni, F Colotta, F Fazi, Frank R. DeLeo, GM Bokoch, H Su, H Xia, I Sabroe, I Sabroe, J Davidson-Moncada, J Savill, J Yu, James W. Catto, JB Johnnidis, JJ Lum, JL Mott, Jon R. Ward, JR Ward, LR Prince, M Merkerova, M Scherr, Marta Milo, MK Whyte, MK Whyte, Moira K. B. Whyte, OD Weiner, P Scapini, PA Davoren, Paul R. Heath, PT Nelson, R Chhabra, R Yi, RE Stringer, RW Watson, S Huang, S Radom-Aizik, S Slezak, SA Renshaw, SD Kobayashi, SD Kobayashi, Stephen A. Renshaw, W Filipowicz, W Huang da, WC Liles, WP Tsang, Y Lee, Y Wang, YZ Pan   +60 more
core   +5 more sources

Influence of sex differences on microRNA gene regulation in disease. [PDF]

, 2014
Sexual dimorphism is observed in most human diseases. The difference in the physiology and genetics between sexes can contribute tremendously to the disease prevalence, severity, and outcome.
Eghbali, Mansoureh, Sharma, Salil
core   +1 more source

Induction of microRNAs, mir-155, mir-222, mir-424 and mir-503, promotes monocytic differentiation through combinatorial regulation [PDF]

, 2010
Acute myeloid leukemia (AML) involves a block in terminal differentiation of the myeloid lineage and uncontrolled proliferation of a progenitor state. Using phorbol myristate acetate (PMA), it is possible to overcome this block in THP-1 cells (an M5-AML ...
A Astrinidis, A Cimmino, A Pession, A Rosa, AD Basso, AW O’Sullivan, BP Lewis, C Esau, C Kanellopoulou, C le Sage, D Gaidatzis, D Liu, D O’Carroll, E Bernstein, E Gottwein, FO Martinez, GA Calin, GA Calin, GK Smyth, H Hohjoh, H Suzuki, H Tazawa, HY Chang, J Kluiver, J Severin, JF Chen, K Kitagawa, K Nie, L Fontana, M Selbach, MD Odero, N Felli, N Standart, PS Linsley, Q Liu, Q Wang, R Edgar, R Medina, R Visone, RJ Mayoral, RJ Taft, RW Georgantas 3rd, S Costinean, S Kang, S Tsuchiya, S Tsuchiya, T Beissbarth, V Martino, W Wang, Y Hayashita, Y Mizuno, YS Lee   +51 more
core   +2 more sources

MicroRNAs in melanoma development and resistance to target therapy [PDF]

, 2017
microRNAs constitute a complex class of pleiotropic post-transcriptional regulators of gene expression involved in the control of several physiologic and pathologic processes.
Ascierto, Paolo Antonio, Ciliberto, Gennaro, Costantini, Susan, Croce, Carlo M, Fattore, Luigi, Malpicci, Debora, Mancini, Rita, Ruggiero, Ciro Francesco   +7 more
core   +1 more source

Exosome-delivered microRNAs promote IFN-α secretion by human plasmacytoid DCs via TLR7 [PDF]

, 2018
The excessive production of type I IFNs is a hallmark and a main pathogenic mechanism of many autoimmune diseases, including systemic lupus erythematosus (SLE).
Andreoli, Laura, Bergese, Paolo, Bosisio, Daniela, Busatto, Sara, D'Oro, Ugo, Giannello, Veronica, Salvi, Valentina, Sozzani, Silvano, Tincani, Angela, Zingoni, Alessandra   +9 more
core   +1 more source

High-throughput, Efficient, and Unbiased Capture of Small RNAs from Low-input Samples for Sequencing. [PDF]

, 2019
MicroRNAs hold great promise as biomarkers of disease. However, there are few efficient and robust methods for measuring microRNAs from low input samples.
Belair, Cassandra D, Blelloch, Robert H, Chu, Brandon, Cooperberg, Matthew R, Freimer, Jacob W, Hu, Tianyi   +5 more
core   +2 more sources

MicroRNAs in the stressed heart: Sorting the signal from the noise [PDF]

, 2014
The short noncoding RNAs, known as microRNAs, are of undisputed importance in cellular signaling during differentiation and development, and during adaptive and maladaptive responses of adult tissues, including those that comprise the heart.
Matkovich, Scot J
core   +3 more sources