Results 21 to 30 of about 282,884 (301)
Diversity in parasitic nematode genomes: the microRNAs of Brugia pahangi and Haemonchus contortus are largely novel [PDF]
, 2012 <b>BACKGROUND:</b> MicroRNAs (miRNAs) play key roles in regulating post-transcriptional gene expression and are essential for development in the free-living nematode Caenorhabditis elegans and in higher organisms.
Winter, A.D. +20 more
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Therapeutic Potentials of MiRNA for Colorectal Cancer Liver Metastasis Treatment: A Narrative Review [PDF]
Iranian Journal of Medical SciencesColorectal cancer (CRC) ranks among the most prevalent cancers worldwide and is the fourth leading cause of cancer-related deaths. Metastasis poses a significant obstacle in CRC treatment, as distant metastasis, particularly to the liver, remains the ...
Amir Hossein Barjasteh +7 more
doaj +1 more source
Effect of Amyloid Beta on Cholesterol Metabolism-Correlated microRNAs in Primary Cultured Astrocytes of C57BL/6J Mice: A Focus on CYP46A1 and APOE Genes [PDF]
Cell JournalObjective: The accumulation of amyloid plaques and disturbance of cholesterol homeostasis are implicated in thepathophysiology of Alzheimer’s disease. Apolipoprotein E (ApoE) and cholesterol 24-hydroxylase (CYP46A1) are keyproteins involved in the efflux
Bahar Jaberian Asl +6 more
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miR-508-5p and mir-510-5p expressions and their relationships with spermatozoa motility and morphology [PDF]
Journal of Shahrekord University of Medical Sciences, 2020 Background and aims:miRNAs have regulatory functions in developmental processes. The stages of spermatogenesis can also be affected by miRNAs. We tried to detect a relationship between the expression of miR-508-5p and miR-510-5p and male infertility. The
Tahere Hasheminiya +3 more
doaj +1 more source
Nucleic Acids Research, 2004 The miRNA Registry provides a service for the assignment of miRNA gene names prior to publication. A comprehensive and searchable database of published miRNA sequences is accessible via a web interface (http://www.sanger.ac.uk/Software/Rfam/mirna/), and all sequence and annotation data are freely available for download.
openaire +4 more sources
Molecular Oncology, 2012 With the advent of next generation sequencing techniques a previously unknown world of non‐coding RNA molecules have been discovered. Non‐coding RNA transcripts likely outnumber the group of protein coding sequences and hold promise of many new discoveries and mechanistic explanations for essential biological phenomena and pathologies.
Jansson, Martin D, Lund, Anders H
openaire +3 more sources
MicroRNAs in fibrosis: opportunities and challenges [PDF]
, 2016 MicroRNAs (miRNAs) are small, non-coding RNAs that mediate mRNA cleavage, translational repression or mRNA destabilisation and are around 22-25 nucleotides in length via partial complementary binding to the 3' untranslated region in target transcripts ...
O'Reilly, Steven, Steven O’Reilly
core +1 more source
MicroRNA-26a-5p: multiple functions, multiple possibilities – a mini-review
Journal of Pre-Clinical and Clinical Research, 2020 Introduction MicroRNA are small RNA molecules about 22 nucleotides long that do not encode proteins. Their function is to change the expression of proteins by attaching to their mRNA.
Paweł Zapolnik, Beata Zapolnik
doaj +1 more source
Improvement of the design and generation of highly specific plant knockdown lines using primary synthetic microRNAs (pri-smiRNAs) [PDF]
, 2010 Niemeier S, Alves jun. L, Merkle T. Improvement of the design and generation of highly specific plant knockdown lines using primary synthetic microRNAs (pri-smiRNAs). BMC Research Notes.
Merkle Thomas +8 more
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Advanced Biomedical Research, 2021 Background: Different genetic variants, including the single-nucleotide polymorphisms (SNPs) present in microRNA recognition elements (MREs) within 3'UTR of genes, can affect miRNA-mediated gene regulation and susceptibility to a variety of human ...
Reyhaneh Dehghanzad +2 more
doaj +1 more source