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The miRNA Registry provides a service for the assignment of miRNA gene names prior to publication. A comprehensive and searchable database of published miRNA sequences is accessible via a web interface (http://www.sanger.ac.uk/Software/Rfam/mirna/), and all sequence and annotation data are freely available for download.
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With the advent of next generation sequencing techniques a previously unknown world of non‐coding RNA molecules have been discovered. Non‐coding RNA transcripts likely outnumber the group of protein coding sequences and hold promise of many new discoveries and mechanistic explanations for essential biological phenomena and pathologies.
Jansson, Martin D, Lund, Anders H
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MicroRNA-26a-5p: multiple functions, multiple possibilities – a mini-review
Introduction MicroRNA are small RNA molecules about 22 nucleotides long that do not encode proteins. Their function is to change the expression of proteins by attaching to their mRNA.
Paweł Zapolnik, Beata Zapolnik
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Background: Different genetic variants, including the single-nucleotide polymorphisms (SNPs) present in microRNA recognition elements (MREs) within 3'UTR of genes, can affect miRNA-mediated gene regulation and susceptibility to a variety of human ...
Reyhaneh Dehghanzad +2 more
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An Insight into Ocular Genetics
Over the past decade, there has been an exponential increase in the database of heritable eye disorders. More than 100,000 germline mutations reported in more than 3,700 different human nuclear genes are associated with inherited diseases.
Shilpa Bisht +3 more
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Amniotic fetal stem cells – derived endothelial progenitors, a support for personalized cardiovascular regenerative medicine [PDF]
Introduction. Worldwide, cardiovascular diseases represent the first cause of morbidity and mortality. The genetic contribution in this pathology is heterogenous, and the microenvironment-genes interactions (mediated by epigenetic mechanisms) influence ...
Cosmin A. BUZILA, Florin IORDACHE
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Predicting the possible effect of miR-203a-3p and miR-29a-3p on DNMT3B and GAS7 genes expression
Aberrant expression of genes involved in methylation, including DNA methyltransferase 3 Beta (DNMT3B), can cause hypermethylation of various tumor suppressor genes.
Ali Afgar +3 more
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Objective To construct a risk model for predicting the prognosis of papillary thyroid carcinoma (PTC) patients based on the expression of microRNAs (miRNA).
JIAO Zhaoshuang, ZHANG Huainian
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Circulating microRNA, secreted microRNA and exogenous plant microRNA [PDF]
Dysregulated expression of microRNAs (miRNAs) in various tissues has been associated with a variety of diseases, including cancers. Here we demonstrate that miRNAs are present in the serum and plasma of humans and other animals such as mice, rats, bovine fetuses, calves and horses.
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MicroRNA-145-5p Regulates the Epithelial-Mesenchymal Transition in Nasal Polyps by Targeting Smad3 [PDF]
Objectives. The annual prevalence of chronic rhinosinusitis (CRS) is increasing, and the lack of effective treatments imposes a substantial burden on both patients and society.
Mengyu Zhang +8 more
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