MicroRNAs in fibrosis: opportunities and challenges [PDF]
, 2016 MicroRNAs (miRNAs) are small, non-coding RNAs that mediate mRNA cleavage, translational repression or mRNA destabilisation and are around 22-25 nucleotides in length via partial complementary binding to the 3' untranslated region in target transcripts ...
O'Reilly, Steven, Steven O’Reilly
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An Insight into Ocular Genetics
Delhi Journal of Ophthalmology, 2017 Over the past decade, there has been an exponential increase in the database of heritable eye disorders. More than 100,000 germline mutations reported in more than 3,700 different human nuclear genes are associated with inherited diseases.
Shilpa Bisht +3 more
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Amniotic fetal stem cells – derived endothelial progenitors, a support for personalized cardiovascular regenerative medicine [PDF]
Archives of the Balkan Medical Union, 2022 Introduction. Worldwide, cardiovascular diseases represent the first cause of morbidity and mortality. The genetic contribution in this pathology is heterogenous, and the microenvironment-genes interactions (mediated by epigenetic mechanisms) influence ...
Cosmin A. BUZILA, Florin IORDACHE
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Improvement of the design and generation of highly specific plant knockdown lines using primary synthetic microRNAs (pri-smiRNAs) [PDF]
, 2010 Niemeier S, Alves jun. L, Merkle T. Improvement of the design and generation of highly specific plant knockdown lines using primary synthetic microRNAs (pri-smiRNAs). BMC Research Notes.
Merkle Thomas +8 more
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Predicting the possible effect of miR-203a-3p and miR-29a-3p on DNMT3B and GAS7 genes expression
Journal of Integrative Bioinformatics, 2021 Aberrant expression of genes involved in methylation, including DNA methyltransferase 3 Beta (DNMT3B), can cause hypermethylation of various tumor suppressor genes.
Ali Afgar +3 more
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Unique and conserved MicroRNAs in wheat chromosome 5D revealed by next-generation sequencing [PDF]
, 2013 MicroRNAs are a class of short, non-coding, single-stranded RNAs that act as post-transcriptional regulators in gene expression. miRNA analysis of Triticum aestivum chromosome 5D was performed on 454 GS FLX Titanium sequences of flow sorted chromosome 5D
Hikmet Budak (150694) +15 more
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MicroRNA-145-5p Regulates the Epithelial-Mesenchymal Transition in Nasal Polyps by Targeting Smad3 [PDF]
Clinical and Experimental OtorhinolaryngologyObjectives. The annual prevalence of chronic rhinosinusitis (CRS) is increasing, and the lack of effective treatments imposes a substantial burden on both patients and society.
Mengyu Zhang +8 more
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miRNAs as Interconnectors between Obesity and Cancer
Non-Coding RNAObesity and cancer are a concern of global interest. It is proven that obesity may trigger the development or progression of some types of cancer; however, the connection by non-coding RNAs has not been totally explored. In the present review, we discuss
Grecia Denisse González-Sánchez +4 more
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Journal of Ardabil University of Medical Sciences, 2022 Background & objectives: Evidence suggests that microRNAs (miRNAs) are essential for immune cell differentiation and function. In addition, miRNAs play an essential role in regulating the expression of pro-inflammatory genes in neurons.
Behrouz Shademan +5 more
doaj
The Non-Canonical Aspects of MicroRNAs: Many Roads to Gene Regulation
Cells, 2019 MicroRNAs (miRNAs) are critical regulators of gene expression. As miRNAs are frequently deregulated in many human diseases, including cancer and immunological disorders, it is important to understand their biological functions.
Christiaan J. Stavast +1 more
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