Results 11 to 20 of about 208,790 (267)

MicroRNA [PDF]

Journal of Allergy and Clinical Immunology, 2018
MicroRNAs (miRNAs) are small endogenous RNAs that regulate gene-expression posttranscriptionally. MiRNA research in allergy is expanding because miRNAs are crucial regulators of gene expression and promising candidates for biomarker development.
Thomas X. Lu, Marc E. Rothenberg
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MicroRNA: MicroRNAs Reach out into Dendrites [PDF]

Current Biology, 2006
A recent study has shown that miR-134, a brain-specific microRNA, is present in dendrites where it represses the local synthesis of the protein kinase LimK1; this is a novel form of translational regulation in dendrites and may have important physiological implications.
Tai, H., Schuman, E.
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MicroRNA or Not MicroRNA? [PDF]

, 2011
The avalanche of next generation sequencing data has led to a rapid increase of annotated microRNAs in the last few years. Many of them are specific to individual species or rather narrow clades. A closer inspection of the current version of miRBase shows that dozens of entries conflict with other ncRNAs, in particular snoRNAs.With few exceptions ...
David Langenberger, Sebastian Bartschat, Jana Hertel, Steve Hoffmann, Hakim Tafer, Peter F. Stadler   +5 more
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Modulation of microRNA Activity by Semi-microRNAs [PDF]

Frontiers in Genetics, 2012
The ribonuclease Dicer plays a central role in the microRNA pathway by catalyzing the formation of 19-24-nucleotide (nt) long microRNAs. Subsequently incorporated into Argonaute 2 (Ago2) effector complexes, microRNAs are known to regulate messenger RNA (mRNA) translation.
Plante, Isabelle, Plé, Hélène, Landry, Patricia, Gunaratne, Preethi H., Provost, Patrick   +4 more
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MicroRNAs and Metastasis [PDF]

Cancers, 2019
Metastasis, the development of secondary malignant growths at a distance from the primary site of a cancer, is associated with almost 90% of all cancer deaths, and half of all cancer patients present with some form of metastasis at the time of diagnosis. Consequently, there is a clear clinical need for a better understanding of metastasis.
Solé, Carla, Lawrie, Charles H.
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Exosomes: From Potential Culprits to New Therapeutic Promise in the Setting of Cardiac Fibrosis

Cells, 2020
Fibrosis is a significant global health problem associated with many inflammatory and degenerative diseases affecting multiple organs, individually or simultaneously.
Roman Tikhomirov, Benedict Reilly-O’ Donnell, Francesco Catapano, Giuseppe Faggian, Julia Gorelik, Fabio Martelli, Costanza Emanueli   +6 more
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MicroRNAs in the Hypothalamus [PDF]

Neuroendocrinology, 2013
MicroRNAs (miRNAs) are short (∼22 nucleotides) non-coding ribonucleic acid (RNA) molecules that negatively regulate the expression of protein-coding genes. Posttranscriptional silencing of target genes by miRNA is initiated by binding to the 3′-untranslated regions of target mRNAs, resulting in specific cleavage and subsequent degradation of the mRNA ...
Meister, Björn, Herzer, Silke, Silahtaroglu, Asli   +2 more
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Therapeutic Potentials of MiRNA for Colorectal Cancer Liver Metastasis Treatment: A Narrative Review [PDF]

Iranian Journal of Medical Sciences
Colorectal cancer (CRC) ranks among the most prevalent cancers worldwide and is the fourth leading cause of cancer-related deaths. Metastasis poses a significant obstacle in CRC treatment, as distant metastasis, particularly to the liver, remains the ...
Amir Hossein Barjasteh, Rawa Jaseb Mazhar AleKassar, Abdulridha Mohammed Al-Asady, Hanieh Latifi, Amir Avan, Majid Khazaei, Mikhail Ryzhikov, Seyed Mahdi Hassanian   +7 more
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Effect of Amyloid Beta on Cholesterol Metabolism-Correlated microRNAs in Primary Cultured Astrocytes of C57BL/6J Mice: A Focus on CYP46A1 and APOE Genes [PDF]

Cell Journal
Objective: The accumulation of amyloid plaques and disturbance of cholesterol homeostasis are implicated in thepathophysiology of Alzheimer’s disease. Apolipoprotein E (ApoE) and cholesterol 24-hydroxylase (CYP46A1) are keyproteins involved in the efflux
Bahar Jaberian Asl, Zahra Nazeri, Seyadeh Pardis Pezeshki, Alireza Kheirollah, Shirin Azizidoost, Maryam Adelipour, Maryam Cheraghzadeh   +6 more
doaj   +1 more source

miR-508-5p and mir-510-5p expressions and their relationships with spermatozoa motility and morphology [PDF]

Journal of Shahrekord University of Medical Sciences, 2020
Background and aims:miRNAs have regulatory functions in developmental processes. The stages of spermatogenesis can also be affected by miRNAs. We tried to detect a relationship between the expression of miR-508-5p and miR-510-5p and male infertility. The
Tahere Hasheminiya, Mohammadreza Saberiyan, Delnya Gholami, Hossein Teimori   +3 more
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