Results 11 to 20 of about 97,236 (208)

miR-802-5p is a key regulator in diabetic kidney disease

Journal of Research in Medical Sciences, 2023
Background: Diabetic kidney disease has substantial burden and limited therapeutic options. An inadequate understanding of the complex gene regulatory circuits underlying this disorder contributes to the insufficiency of current treatment strategies ...
Farnoush Kiyanpour, Maryam Abedi, Yousof Gheisari   +2 more
doaj   +1 more source

MicroRNAs regulatory networks in cardiotoxicity [PDF]

, 2012
A long time and many steps are needed to bring valuable drugs to patients. Drugs not only have to be effective against the disease which they are intended for, but also safe. All drugs cause toxic effects in proportion to the dose (Paracelsus, ca.
Vacchi-Suzzi, Caterina
core   +1 more source

Exosomes: From Potential Culprits to New Therapeutic Promise in the Setting of Cardiac Fibrosis

Cells, 2020
Fibrosis is a significant global health problem associated with many inflammatory and degenerative diseases affecting multiple organs, individually or simultaneously.
Roman Tikhomirov, Benedict Reilly-O’ Donnell, Francesco Catapano, Giuseppe Faggian, Julia Gorelik, Fabio Martelli, Costanza Emanueli   +6 more
doaj   +1 more source

A Database for TSSs of Human MicroRNAs [PDF]

, 2012
MicroRNAs (miRNAs) are small endogeneous non-coding RNAs of about 22nt length. These short RNAs regulate the expression of mRNAs by hybridizing with their 3'-UTRs or by translational repression.
Sanghamitra Bandyopadhyay, Malay Bhattacharyya, Malay Bhattacharyya, Sanghamitra B   +3 more
core   +1 more source

Diversity in parasitic nematode genomes: the microRNAs of Brugia pahangi and Haemonchus contortus are largely novel [PDF]

, 2012
<b>BACKGROUND:</b> MicroRNAs (miRNAs) play key roles in regulating post-transcriptional gene expression and are essential for development in the free-living nematode Caenorhabditis elegans and in higher organisms.
Winter, A.D., Weir, W., Hunt Martin, Gilleard, J.S., Berriman, M., Devaney, E., Collette Britton, Alan D Winter, Gilleard John S, Britton Collette, Winter Alan D, Martin Hunt, Hunt, M., Devaney Eileen, Britton, C., Matthew Berriman, Eileen Devaney, John S Gilleard, Weir William, Berriman Matthew, William Weir   +20 more
core   +1 more source

Therapeutic Potentials of MiRNA for Colorectal Cancer Liver Metastasis Treatment: A Narrative Review [PDF]

Iranian Journal of Medical Sciences
Colorectal cancer (CRC) ranks among the most prevalent cancers worldwide and is the fourth leading cause of cancer-related deaths. Metastasis poses a significant obstacle in CRC treatment, as distant metastasis, particularly to the liver, remains the ...
Amir Hossein Barjasteh, Rawa Jaseb Mazhar AleKassar, Abdulridha Mohammed Al-Asady, Hanieh Latifi, Amir Avan, Majid Khazaei, Mikhail Ryzhikov, Seyed Mahdi Hassanian   +7 more
doaj   +1 more source

miR-508-5p and mir-510-5p expressions and their relationships with spermatozoa motility and morphology [PDF]

Journal of Shahrekord University of Medical Sciences, 2020
Background and aims:miRNAs have regulatory functions in developmental processes. The stages of spermatogenesis can also be affected by miRNAs. We tried to detect a relationship between the expression of miR-508-5p and miR-510-5p and male infertility. The
Tahere Hasheminiya, Mohammadreza Saberiyan, Delnya Gholami, Hossein Teimori   +3 more
doaj   +1 more source

Effect of Amyloid Beta on Cholesterol Metabolism-Correlated microRNAs in Primary Cultured Astrocytes of C57BL/6J Mice: A Focus on CYP46A1 and APOE Genes [PDF]

Cell Journal
Objective: The accumulation of amyloid plaques and disturbance of cholesterol homeostasis are implicated in thepathophysiology of Alzheimer’s disease. Apolipoprotein E (ApoE) and cholesterol 24-hydroxylase (CYP46A1) are keyproteins involved in the efflux
Bahar Jaberian Asl, Zahra Nazeri, Seyadeh Pardis Pezeshki, Alireza Kheirollah, Shirin Azizidoost, Maryam Adelipour, Maryam Cheraghzadeh   +6 more
doaj   +1 more source

MicroRNA-26a-5p: multiple functions, multiple possibilities – a mini-review

Journal of Pre-Clinical and Clinical Research, 2020
Introduction MicroRNA are small RNA molecules about 22 nucleotides long that do not encode proteins. Their function is to change the expression of proteins by attaching to their mRNA.
Paweł Zapolnik, Beata Zapolnik
doaj   +1 more source

Prediction of single-nucleotide polymorphisms within microRNAs binding sites of neuronal genes related to multiple sclerosis: A preliminary study

Advanced Biomedical Research, 2021
Background: Different genetic variants, including the single-nucleotide polymorphisms (SNPs) present in microRNA recognition elements (MREs) within 3'UTR of genes, can affect miRNA-mediated gene regulation and susceptibility to a variety of human ...
Reyhaneh Dehghanzad, Somayeh Panahi Moghadam, Zeinab Shirvani Farsani   +2 more
doaj   +1 more source