Results 31 to 40 of about 97,236 (208)
SNP analysis reveals an evolutionary acceleration of the human-specific microRNAs [PDF]
, 2008 MicroRNAs are one class of important gene regulators at the post-transcriptional level by binding to the 3’UTRs of target mRNAs. It has been reported that human microRNAs are evolutionary conserved and show lower single nucleotide polymorphisms ...
Qipeng Zhang, Qinghua Cui, Ming Lu
core
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Detection of MicroRNAs in Dried Serum Blots [PDF]
, 2010 MicroRNAs are short RNAs which can be utilized as biomarkers for a variety of conditions. They are detectable in serum, and changes in the levels of circulating microRNAs have been associated with different diseases.
Santosh K. Patnaik +2 more
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MicroRNAs in Diffuse Large B-Cell Lymphoma
, 2013 Diffuse large B‐cell lymphoma (DLBCL), the most common sub‐type of non‐Hodgkin's lymphomas (NHL), is a genetically and clinically heterogeneous disease.
Alencar, Alvaro J +3 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
A glance into the roles of microRNAs (exosomal and non-exosomal) in polycystic ovary syndrome [PDF]
Obstetrics & Gynecology SciencePolycystic ovarian syndrome (PCOS) is a common endocrine disorder in women of reproductive age. The clinical symptoms include hyperandrogenism, chronic anovulation, and multiple ovarian cysts.
Afsane Masoudi Chelegahi +3 more
doaj +1 more source
Cardiac microRNAs: diagnostic and therapeutic potential
Archives of Medical Science, 2023 MicroRNAs are small non-coding post-translational biomolecules which, when expressed, modify their target genes. It is estimated that microRNAs regulate production of approximately 60% of all human proteins and enzymes that are responsible for major ...
Anna Kabłak-Ziembicka +5 more
doaj +1 more source
Insights into role of microRNAs in cardiac development, cardiac diseases, and developing novel therapies [PDF]
Iranian Journal of Basic Medical Sciences, 2020 Objective(s): MicroRNAs (miRNAs) are a subfamily of small noncoding RNAs that play a variety of roles in regulating gene expression in nearly all organisms. They affect different biological pathways by post-transcriptionally regulating mRNAs.
Maedeh Arabian +3 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Die Bedeutung von microRNAs für die Funktion von Endothelzellen [PDF]
, 2009 Dicer and Drosha are the major enzymes involved in microRNA processing. Using siRNA targeting Dicer and Drosha, thereby downregulating a substantial number of microRNAs in EC, we demonstrate a crucial role of both enzymes in angiogenic processes ...
Bonauer, Angelika
core