Results 41 to 50 of about 208,790 (267)

Insights into role of microRNAs in cardiac development, cardiac diseases, and developing novel therapies [PDF]

Iranian Journal of Basic Medical Sciences, 2020
Objective(s): MicroRNAs (miRNAs) are a subfamily of small noncoding RNAs that play a variety of roles in regulating gene expression in nearly all organisms. They affect different biological pathways by post-transcriptionally regulating mRNAs.
Maedeh Arabian, Fatemeh Mirzadeh Azad, Majid Maleki, Mahshid Malakootian   +3 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Transcriptomic profile assessment for preeclampsia prediction and early diagnostics

Акушерство, гинекология и репродукция
Aim: to develop a model for predicting preeclampsia (PE) based on the clinically most significant differentially expressed plasma microRNAs.Materials and Methods. A prospective observational comparative study was conducted with 62 women, divided into two
A. V. Melnik, V. E. Solovyova, Yu. O. Yatsenko, A. E. Filippova, E. G. Asryan, T. Е. Seitumerov, E. R. Myshak, Yu. A. Chernysheva, S. A. Ziyadinova, V. O. Kononenko, M. R. Kadyrova, A. A. Denisenko, K. T. Ismagilova, D. V. Mushinsky, L. E. Sorokina   +14 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Curcumin inhibits migration and invasion of non-small cell lung cancer cells through up-regulation of miR-206 and suppression of PI3K/AKT/mTOR signaling pathway

Acta Pharmaceutica, 2020
Curcumin has been proved to inhibit cell proliferation and induce cell apoptosis in non-small cell lung cancer (NSCLC). However, little is known about antimetastatic effects and molecular mechanisms of curcumin in NSCLC.
Wang Naizhi, Feng Tao, Liu Xiaona, Liu Qin   +3 more
doaj   +1 more source

MicroRNA Expression Profiles of Epicardial Adipose Tissue-Derived Exosomes in Patients with Coronary Atherosclerosis

Reviews in Cardiovascular Medicine, 2022
Background and Aims: Epicardial adipose tissue, exosomes, and miRNAs have important activities in atherosclerosis. The purpose of this study was to establish miRNA expression profiles of epicardial adipose tissue-derived exosomes in patients with ...
Jinxing Liu, Ang Gao, Yan Liu, Yan Sun, Dai Zhang, Xuze Lin, Chengping Hu, Yong Zhu, Yu Du, Hongya Han, Yang Li, Shijun Xu, Taoshuai Liu, Chenhan Zhang, Junming Zhu, Ran Dong, Yujie Zhou, Yingxin Zhao   +17 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

MicroRNA-34, microRNA-130, microRNA-148, microRNA-181, microRNA-194 and microRNA-605 expression in colon cancer tissue

South Russian Journal of Cancer
Purpose of the study. Determination of the expression of microRNA‑34, microRNA‑130, microRNA‑148, microRNA‑181, microRNA‑194 and microRNA‑605 in colon tumor tissue depending on the clinical and morphological features of the tumor and the effectiveness of treatment.Materials and methods.
D. I. Azovsky, S. G. Afanasyev, A. V. Avgustinovich, L. V. Spirina, I. V. Kovaleva, A. B. Zinnurova, V. A. Belova   +6 more
openaire   +2 more sources

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

microRNA Bioinformatics

Cells, 2022
Firstly, I apologize for the delayed publication of this Special Issue in the form of a book title [...]
openaire   +3 more sources