Results 41 to 50 of about 97,236 (208)

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

microRNA in cellular senescence [PDF]

, 2010
Senescence is recognized as a permanent arrest of cell proliferation triggered by telomere shortening or various stresses. Senescence imposes a barrier to tumorigenesis and contributes to aging.
Sedia, Carla
core   +1 more source

Transcriptomic profile assessment for preeclampsia prediction and early diagnostics

Акушерство, гинекология и репродукция
Aim: to develop a model for predicting preeclampsia (PE) based on the clinically most significant differentially expressed plasma microRNAs.Materials and Methods. A prospective observational comparative study was conducted with 62 women, divided into two
A. V. Melnik, V. E. Solovyova, Yu. O. Yatsenko, A. E. Filippova, E. G. Asryan, T. Е. Seitumerov, E. R. Myshak, Yu. A. Chernysheva, S. A. Ziyadinova, V. O. Kononenko, M. R. Kadyrova, A. A. Denisenko, K. T. Ismagilova, D. V. Mushinsky, L. E. Sorokina   +14 more
doaj   +1 more source

Curcumin inhibits migration and invasion of non-small cell lung cancer cells through up-regulation of miR-206 and suppression of PI3K/AKT/mTOR signaling pathway

Acta Pharmaceutica, 2020
Curcumin has been proved to inhibit cell proliferation and induce cell apoptosis in non-small cell lung cancer (NSCLC). However, little is known about antimetastatic effects and molecular mechanisms of curcumin in NSCLC.
Wang Naizhi, Feng Tao, Liu Xiaona, Liu Qin   +3 more
doaj   +1 more source

MicroRNA Expression Profiles of Epicardial Adipose Tissue-Derived Exosomes in Patients with Coronary Atherosclerosis

Reviews in Cardiovascular Medicine, 2022
Background and Aims: Epicardial adipose tissue, exosomes, and miRNAs have important activities in atherosclerosis. The purpose of this study was to establish miRNA expression profiles of epicardial adipose tissue-derived exosomes in patients with ...
Jinxing Liu, Ang Gao, Yan Liu, Yan Sun, Dai Zhang, Xuze Lin, Chengping Hu, Yong Zhu, Yu Du, Hongya Han, Yang Li, Shijun Xu, Taoshuai Liu, Chenhan Zhang, Junming Zhu, Ran Dong, Yujie Zhou, Yingxin Zhao   +17 more
doaj   +1 more source

MicroRNAs in cardiac arrhythmia: DNA sequence variation of MiR-1 and MiR-133A in long QT syndrome. [PDF]

, 2014
Long QT syndrome (LQTS) is a genetic cardiac condition associated with prolonged ventricular repolarization, primarily a result of perturbations in cardiac ion channels, which predisposes individuals to life-threatening arrhythmias.
Corfield, VA, Christiansen, M, Corfield, Valerie A, Christiansen, Kasper M, Carlsen, AL, Christiansen, KM, Carlsen, Anting L, Behr, Elijah R, Kanters, JK, Hedley, Paula L, Kanters, Jørgen K., Christiansen, Michael, Behr, ER, Hedley, PL   +13 more
core   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

CHO microRNA engineering is growing up : recent successes and future challenges [PDF]

, 2013
microRNAs with their ability to regulate complex pathways that control cellular behavior and phenotype have been proposed as potential targets for cell engineering in the context of optimization of biopharmaceutical production cell lines, specifically of
Grillari, Johannes, Heffner, Kelley M., Shridhar, Smriti, Borth, Nicole, Barron, Niall, Betenbaugh, Mike, Shiloach, Joseph, Chung, Cheng-Yu, Hackl, Matthias, Kreil, David, Jadhav, Vaibhav, Druz, Aliaksandr   +11 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Shared and organ-specific gene-expression programs during the development of the cochlea and the superior olivary complex

RNA Biology, 2023
The peripheral and central auditory subsystems together form a complex sensory network that allows an organism to hear. The genetic programs of the two subsystems must therefore be tightly coordinated during development.
Mor Bordeynik-Cohen, Michal Sperber, Lena Ebbers, Naama Messika-Gold, Constanze Krohs, Tal Koffler-Brill, Yael Noy, Ran Elkon, Hans Gerd Nothwang, Karen B. Avraham   +9 more
doaj   +1 more source