Results 51 to 60 of about 97,236 (208)

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Functional and cell-specific regulation of the Brn-3b transcription factor by microRNAs [PDF]

, 2010
Post-transcriptional gene regulation is a very powerful and evolutionary conserved mechanism which allows cells to finely modulate gene expression by acting at the level of their mRNAs.
Calissano, M.
core  

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Evaluation of miR-146a as a potential biomarker for diagnosis of cardiotoxicity induced by chemotherapy in patients with breast cancer

Journal of Research in Medical Sciences
Background: Cardiotoxicity from chemotherapy may result in cardiomyopathy and heart failure. Clinicians can use the evaluation of cardiotoxicity-specific biomarkers, such as microRNA, as a tool for the early detection of cardiotoxicity.
Nasrin Zare, Nasim Dana, Azam Mosayebi, Golnaz Vaseghi, Shaghayegh Haghjooy Javanmard   +4 more
doaj   +1 more source

MicroRNA-374a Expression as a Prognostic Biomarker in Lung Adenocarcinoma [PDF]

Journal of Pathology and Translational Medicine, 2019
Background Lung cancer is the most common cause of cancer-related death, and adenocarcinoma is the most common histologic subtype. MicroRNA is a small non-coding RNA that inhibits multiple target gene expression at the post-transcriptional level and is ...
Yeseul Kim, Jongmin Sim, Hyunsung Kim, Seong Sik Bang, Seungyun Jee, Sungeon Park, Kiseok Jang   +6 more
doaj   +1 more source

Micro RNAs of Epstein-Barr virus promote cell cycle progression and prevent apoptosis of primary human B cells. [PDF]

, 2010
Cellular and viral microRNAs (miRNAs) are involved in many different processes of key importance and more than 10,000 miRNAs have been identified so far.
Seto, Eri, Walz, Nicole, Moosmann Andreas, Hammerschmidt, W., Grömminger, Sebastian, Andreas Moosmann, Wolfgang Hammerschmidt, Adam Grundhoff, Grömminger, S., Hammerschmidt Wolfgang, Grömminger Sebastian, Seto, E., Hammerschmidt, Wolfgang, Grundhoff Adam, Nicole Walz, Walz, N., Grundhoff, A., Moosmann, A., Walz Nicole, Grundhoff, Adam, Sebastian Grömminger, Seto Eri, Moosmann, Andreas, Eri Seto   +23 more
core   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Association of MicroRNA-103 expression with Type 2 Diabetes Mellitus [PDF]

Caspian Journal of Internal Medicine
Background: Type 2 diabetes mellitus (T2DM), the most prevalent metabolic disorder worldwide, has genetic, epigenetic, and environmental contributors. Among them, circulating microRNAs (miRNAs/miRs) have attracted considerable attention. This study aimed
Mahnoosh Rafiee, Farzin Sadeghi, Ali Mirzapour, Soraya Khafri, Bahare Korani, Atiyeh Al-e-Ahmad, Hadi Parsian   +6 more
doaj  

Mammalian cells in culture actively export specific microRNAs [PDF]

, 2009
The discovery of microRNAs (miRNAs) as a new class of regulators of gene expression has triggered an explosion of research, but has left many unanswered questions about how this regulation works and how it is integrated with other regulatory mechanisms ...
David J. Galas, Shile Zhang, Jessica Weber, David Baxter, Kai Wang   +4 more
core  

Differential expression of exosomal microRNAs in prefrontal cortices of schizophrenia and bipolar disorder patients [PDF]

, 2013
Exosomes are cellular secretory vesicles containing microRNAs (miRNAs). Once secreted, exosomes are able to attach to recipient cells and release miRNAs potentially modulating the function of the recipient cell.
Andrea Schmitt, Howard Cabral, Vanderburg, Charles, Delalle, Ivana, Ashley R. Winslow (277744), Cagsal-Getkin, Ozge, Vanderburg, Charles R., Joan Costa (277746), Costa Joan, Medina, Juan, Anja Schneider, Cagsal-Getkin Ozge, James A Kozubek, Charles R. Vanderburg (239921), Winslow Ashley R., Kozubek, James A., Winslow, Ashley R., Howard Cabral (277749), Kao, Patricia F., Ozge Cagsal-Getkin, Juan Medina (277745), Meredith G. Banigan (239919), Schmitt Andrea, Juan Medina, Ivana Delalle, Banigan Meredith G., Meredith G Banigan, Schneider Anja, Schneider, Anja, Ashley R Winslow, James A. Kozubek (277743), Vanderburg Charles R., Patricia F. Kao (239917), Anja Schneider (277748), Winslow, Ashley R, Joan Costa, Kozubek James A., Banigan, Meredith G., Costa, Joan, Cabral Howard, Delalle Ivana, Ozge Cagsal-Getkin (277750), Charles R Vanderburg, Andrea Schmitt (277747), Cabral, Howard, Kao Patricia F., Medina Juan, Ivana Delalle (239923), Patricia F Kao, Schmitt, Andrea   +49 more
core   +1 more source