Results 51 to 60 of about 282,884 (301)
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
A glance into the roles of microRNAs (exosomal and non-exosomal) in polycystic ovary syndrome [PDF]
Obstetrics & Gynecology SciencePolycystic ovarian syndrome (PCOS) is a common endocrine disorder in women of reproductive age. The clinical symptoms include hyperandrogenism, chronic anovulation, and multiple ovarian cysts.
Afsane Masoudi Chelegahi +3 more
doaj +1 more source
SNP analysis reveals an evolutionary acceleration of the human-specific microRNAs [PDF]
, 2008 MicroRNAs are one class of important gene regulators at the post-transcriptional level by binding to the 3’UTRs of target mRNAs. It has been reported that human microRNAs are evolutionary conserved and show lower single nucleotide polymorphisms ...
Qipeng Zhang, Qinghua Cui, Ming Lu
core
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Cardiac microRNAs: diagnostic and therapeutic potential
Archives of Medical Science, 2023 MicroRNAs are small non-coding post-translational biomolecules which, when expressed, modify their target genes. It is estimated that microRNAs regulate production of approximately 60% of all human proteins and enzymes that are responsible for major ...
Anna Kabłak-Ziembicka +5 more
doaj +1 more source
Insights into role of microRNAs in cardiac development, cardiac diseases, and developing novel therapies [PDF]
Iranian Journal of Basic Medical Sciences, 2020 Objective(s): MicroRNAs (miRNAs) are a subfamily of small noncoding RNAs that play a variety of roles in regulating gene expression in nearly all organisms. They affect different biological pathways by post-transcriptionally regulating mRNAs.
Maedeh Arabian +3 more
doaj +1 more source
Journal of Orthopaedic Research, 2013 ABSTRACTmicroRNAs are small non‐coding RNAs that in the last decade have emerged as overarching regulators of gene expression. Their abundance, ability to repress a large number of target genes and overlapping target specificity indicate a complex network of interactions that is still being defined.
Gary, Gibson, Hiroshi, Asahara
openaire +2 more sources
Die Bedeutung von microRNAs für die Funktion von Endothelzellen [PDF]
, 2009 Dicer and Drosha are the major enzymes involved in microRNA processing. Using siRNA targeting Dicer and Drosha, thereby downregulating a substantial number of microRNAs in EC, we demonstrate a crucial role of both enzymes in angiogenic processes ...
Bonauer, Angelika
core
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
microRNAs in the control of lymphocytes response [PDF]
, 2009 Recently, it has become evident the importance of miRNAs in regulating immune response, as well as immune cell development. During my phD fellow I focused my attention on the relationship B-lymphocytes-microRNA; in particular I examined two the different
Rossi, Annalisa
core +1 more source