Results 51 to 60 of about 357,095 (308)
Functional microRNA high throughput screening reveals miR-9 as a central regulator of liver oncogenesis by affecting the PPARA-CDH1 pathway [PDF]
, 2015 Background: Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths, reflecting the aggressiveness of this type of cancer and the absence of effective therapeutic regimens.
Drakaki, A +7 more
core +2 more sources
Exploring Epigenetic Mechanisms in Aggressive Periodontitis; Unraveling the Molecular Dynamics of Disease Progression: A Narrative Review [PDF]
Iranian Journal of Medical SciencesAggressive periodontitis is an inflammation of the periodontal tissue that usually affects adolescents and young adults aged
Ranny Grevanny +3 more
doaj +1 more source
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Modulation of microRNA Activity by Semi-microRNAs [PDF]
Frontiers in Genetics, 2012 The ribonuclease Dicer plays a central role in the microRNA pathway by catalyzing the formation of 19-24-nucleotide (nt) long microRNAs. Subsequently incorporated into Argonaute 2 (Ago2) effector complexes, microRNAs are known to regulate messenger RNA (mRNA) translation.
Plante, Isabelle +4 more
openaire +2 more sources
International Journal of Nephrology and Renovascular Disease, 2020 Seyyedeh Mina Hejazian,1– 3 Mohammadreza Ardalan,2 Mohammadali M Shoja,4 Nasser Samadi,1 Sepideh Zununi Vahed2 1Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran; 2Kidney ...
Hejazian SM +4 more
doaj
Expression of miRNA-25 in young and old lung adenocarcinoma
Journal of Research in Medical Sciences, 2021 Background: An appropriate personalized molecular testing ensures the most efficacious treatment in lung cancer. It is still controversial whether younger lung adenocarcinoma (LUAD) patients have different molecular features compared with their older ...
Laura Boldrini +4 more
doaj +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Molecular medicine of microRNAs: structure, function and implications for diabetes [PDF]
, 2008 MicroRNAs (miRNAs) are a family of endogenous small noncoding RNA molecules, of 19–28 nucleotides in length. In humans, up to 3% of all genes are estimated to encode these evolutionarily conserved sequences.
Duncan +5 more
core +1 more source
Regulation of Cardiac MicroRNAs by Cardiac MicroRNAs [PDF]
Circulation Research, 2013 Rationale: MicroRNAs modestly suppress their direct mRNA targets, and these direct effects are amplified by modulation of gene transcription pathways. Consequently, indirect mRNA modulatory effects of microRNAs to increase or decrease mRNAs greatly outnumber direct target suppressions.
Scot J, Matkovich +2 more
openaire +2 more sources
MiRNA-Based Inspired Approach in Diagnosis of Prostate Cancer
Medicina, 2020 Prostate cancer is one of the most encountered cancer diseases in men worldwide and in consequence it requires the improvement of therapeutic strategies. For the clinical diagnosis, the standard approach is represented by solid biopsy.
Vlad Cristian Munteanu +5 more
doaj +1 more source