Results 61 to 70 of about 319,465 (163)
EVALUATION OF THE PLASMA MICRO RNA EXPRESSION LEVELS IN SECONDARY HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS
Mediterranean Journal of Hematology and Infectious Diseases, 2013 Background: Hemophagocytic lymphohistiocytosis (HLH) is a life threatening hyper inflammatory disease. Micro RNAs (miRNA) are about 22 nucleotide-long, small RNAs encoded with genes, and they have regulatory functions in immune response.
Ali Bay +5 more
doaj +1 more source
Clinical and Translational Medicine, 2017 Background Serial analysis of biomarkers in the circulation of patients undergoing treatment (“liquid biopsies”) can provide new insights into drug effects.
Narayan Shivapurkar +4 more
doaj +1 more source
Frontiers in Genetics, 2020 Early studies have provided a wealth of information on the functions of microRNAs (miRNAs). However, less is known regarding their functions in the hypothalamus involved in sheep reproduction. To explore the potential roles of hypothalamic messenger RNAs
Zhuangbiao Zhang +10 more
doaj +1 more source
Differential expression of microRNAs in adipose tissue after long-term high-fat diet-induced obesity in mice. [PDF]
PLoS ONE, 2012 Obesity is a major health concern worldwide which is associated with increased risk of chronic diseases such as metabolic syndrome, cardiovascular disease and cancer.
Dionysios V Chartoumpekis +6 more
doaj +1 more source
MiR-21-5p, miR-18a-5p, miR-27a-3p and miR-423-5p expression in AMI_T0 and CAD groups (n = 3).
, 2019 (A) MiR-21-5p expression in CAD and AMI_T0 groups. Mann-Whitney U = 196, n.s. (B) MiR-18a-5p expression in CAD and AMI_T0 groups. Mann-Whitney U = 190, n.s. (C) MiR-27a-3p expression in CAD and AMI_T0 groups. Mann-Whitney U = 106, n.s.
Ruggiero Mango (266696) +11 more
core +1 more source
Advanced Science, Volume 13, Issue 31, 4 June 2026.RNF213 is characterized as a dual‐functional antiviral effector. It directly mediates the degradation of the influenza A virus nucleoprotein (NP) while simultaneously activating the MDA5‐mediated innate immune signaling pathway. This coordinated response establishes a powerful host defense system against viral infection. ABSTRACT Influenza A virus (IAV)
Haoning Li +5 more
wiley +1 more source
BCL11A expression was negatively regulated by hsa-miR-190b-5p.
, 2023 (A, B) qRT-PCR and Western blot analysis of the mRNA and protein expression levels of BCL11A in 293T cells after transfected hsa-miR-190b-5p mimics and negative control mimics. β-actin gene was used as the internal control. (C) hsa-miR-190b-5p expression
Hailong Huang (1449589) +9 more
core +1 more source
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, Volume 13, Issue 35, 24 June 2026.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Frontiers in Genetics, 2020 Some differentially expressed genes (DEGs) that encode key enzymes involved in steroidogenic biosynthesis (CYP19A1) and key molecules related to gonadal functions (DMRT1, SOX9, AMH, FOXL2, WNT4, RSPO2, and GDF9) have been identified in adult gonadal RNA ...
Lei Xiong +11 more
doaj +1 more source
, 2019 Although the cancer/testis antigen CAGE has been implicated in tumorigenesis, the molecular mechanisms of CAGE-promoted tumorigenesis remain largely unknown.
Seungheon Lee (7862393) +5 more
core +1 more source