Results 21 to 30 of about 4,116 (175)

miR-379-5P INHIBITION ENHANCES INTESTINAL EPITHELIAL PROLIFERATION AND BARRIER FUNCTION RECOVERY AFTER ISCHEMIA/REPERFUSION BY TARGETING EIF4G2. [PDF]

Shock, 2023
ABSTRACT Gut barrier dysfunction caused by intestinal ischemia/reperfusion (I/R) injury is associated with substantial death and morbidity. In this research, the role of microRNAs (miRNAs) in regulating intestinal I/R injury was investigated. We used miRNA sequencing to analyze clinical ischemic and normal intestinal samples.
Jia Z, Wang Y, Gao J, Zheng M, Wang P, Zu G.   +5 more
europepmc   +3 more sources

LINC00665 promotes breast cancer progression through regulation of the miR-379-5p/LIN28B axis. [PDF]

Cell Death Dis, 2020
AbstractBreast cancer is the most common malignant tumor among women worldwide. Although increasing evidence indicates that long noncoding RNAs (lncRNAs) play critical roles during breast tumorigenesis and progression, the involvement of most lncRNAs in breast cancer remains largely unknown. In the current study, we demonstrated that LINC00665 promotes
Ji W, Diao YL, Qiu YR, Ge J, Cao XC, Yu Y.   +5 more
europepmc   +4 more sources

Endogenous and Extracellular Roles of a Tumor Suppressor miR-379-5p in Gastric Cancer.

Oncology
<p>Introduction: MiRNAs play important roles in development of various cancers including gastric cancer. Exosomes are extracellular vesicles for translocating molecules. This study aimed to investigate the tumor suppressive roles of miR-379-5p in gastric cancer and to investigate the roles of exosomes in transporting miR-379-5p from intracellular
Liu MX, Chu KM.
europepmc   +3 more sources

miR‑379‑5p inhibits cell proliferation and promotes cell apoptosis in non‑small cell lung cancer by targeting β‑arrestin‑1. [PDF]

Mol Med Rep, 2020
Lung cancer is the most common fatal type of cancer, demonstrating high incidence rates in both sexes. Therefore, it is of vital importance to devise more effective and targeted therapies to improve the treatment quality for patients. The present study aimed to determine the effects of microRNA (miR)‑379‑5p on cell proliferation and apoptosis, in ...
Jiang Y, Zhu P, Gao Y, Wang A.
europepmc   +4 more sources

Author Correction: hsa_circ_0008305 facilitates the malignant progression of hepatocellular carcinoma by regulating AKR1C3 expression and sponging miR-379-5p. [PDF]

Sci Rep
Huang S, Liu K, Xu Y, Wang H, Fu S, Wu J.   +5 more
europepmc   +3 more sources

miR-379-5p inhibits proliferation and invasion of the endometrial cancer cells by inhibiting expression of ROR1

Acta Biochimica Polonica, 2021
Endometrial cancer is a common gynecological malignancy, and the incidence of this disease has increased in recent years. Recently, some studies suggested that the expression of miR-379-5p suppressed the metastasis of breast cancer cells. However, whether the expression of miR-379-5p could affect the proliferation, migration and invasion of endometrial
Minglin, Liang, Hui, Chen, Jie, Min
openaire   +3 more sources

MicroRNA‐379‐5p targets MAP3K2 to reduce autophagy and alleviate neuronal injury following cerebral ischemia via the JNK/c‐Jun signaling pathway

Kaohsiung Journal of Medical Sciences, 2022
MicroRNAs (miRNAs) are abundant in neurons and play key roles in the function and development of the nervous system. This study focuses on the function of miR‐379‐5p in neurological function recovery during ischemic stroke.
Yun Mo, Yin‐Yi Sun, Erli Yue, Yuan Liu, Kang‐Yong Liu   +4 more
doaj   +1 more source

MicroRNA-379-5p regulates free cholesterol accumulation and relieves diet induced-liver damage in db/db mice via STAT1/HMGCS1 axis

Molecular Biomedicine, 2022
Lipotoxicity induced by the overload of lipid in the liver, especially excess free cholesterol (FC), has been recognized as one of driving factors in the transition from non-alcoholic fatty liver (NAFL) to non-alcoholic steatohepatitis (NASH).
Yunxia Dong, Chuwei Yu, Ningning Ma, Xiaoding Xu, Qian Wu, Henglei Lu, Likun Gong, Jing Chen, Jin Ren   +8 more
doaj   +1 more source

A Concise Review on Dysregulation of LINC00665 in Cancers

Cells, 2022
Long Intergenic Non-Protein Coding RNA 665 (LINC00665) is an RNA gene located on the minus strand of chromosome 19. This lncRNA acts as a competing endogenous RNA for miR-4458, miR-379-5p, miR-551b-5p, miR-3619-5p, miR-424-5p, miR-9-5p, miR-214-3p, miR ...
Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Aria Baniahmad, Mohammad Taheri, Mohammadreza Hajiesmaeili   +5 more
doaj   +1 more source

AKR1C3 decreased CML sensitivity to Imatinib in bone marrow microenvironment via dysregulation of miR-379-5p

Cellular Signalling, 2021
Drug resistance is an important cause of death for most patients with chronic myeloid leukemia (CML). The bone marrow microenvironment is believed to be mainly responsible for resistance to BCR-ABL tyrosine kinase inhibitors. The mechanism involved, however, is still unclear.Bioinformatic analysis from GEO database of AKR1C3 was utilized to identify ...
Di, Pan, Wanwan, Yang, Yao, Zeng, Wenjun, Li, Kaizhen, Wang, Li, Zhao, Jia, Li, Yuting, Ye, Qinglong, Guo   +8 more
openaire   +2 more sources