Results 91 to 100 of about 2,403,682 (282)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, Volume 20, Issue 6, Page 1591-1611, June 2026.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

The interaction between jets and clouds in the 3CR galaxies [PDF]

, 2008
From the HST/WFPC2 3CR Snapshot Survey, data taken with the filter F555W, F702W and narrow-ramp, a set of galaxies with noticeable extended structure were selected (e.g. 3C 79, 3C 135, 3C 234, etc).
Feinstein Baigorri, Carlos, Hägele, G. F., Macchetto, D. F., Montero, F.   +3 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

STATIC AND DYNAMIC POSTURE CONTROL IN POSTLINGUAL COCHLEAR IMPLANTED PATIENTS: Effects of dual-tasking, visual and auditory inputs suppression

Frontiers in Integrative Neuroscience, 2014
Posture control is based on central integration of multisensory inputs, and on internal representation of body orientation in space. This multisensory feedback regulates posture control and continuously updates the internal model of body’s position which
BERNARD DEMANZE eLaurence, BERNARD DEMANZE eLaurence, LEONARD eJacques, DUMITRESCU eMichel, MELLER eRenaud, MAGNAN eJacques, LACOUR eMichel   +6 more
doaj   +1 more source

ESTUDIO BIBLIOMÉTRICO DE LAS REVISTAS 3C EMPRESA, 3C TIC Y 3C TECNOLOGÍA [PDF]

3C Tecnología_Glosas de innovación aplicadas a la pyme, 2017
En el siguiente trabajo se realiza un estudio bibliometrico sobre las tres revistas de la Editorial 3Ciencias: 3C Empresa, 3C TIC y 3C Tecnologia, con el objetivo de examinar y analizar las caracteristicas de las publicaciones y los autores de la Editorial 3Ciencias y su desarrollo entre los anos 2012 y 2016.
openaire   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, Volume 20, Issue 6, Page 1612-1625, June 2026.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Biochemical characterization of recombinant Avihepatovirus 3C protease and its localization

Virology Journal, 2019
Background The picornaviral 3C protease mediates viral polyprotein maturation and multiple cleavages of host proteins to modulate viral translation and transcription.
Di Sun, Mingshu Wang, Xingjian Wen, Sai Mao, Anchun Cheng, Renyong Jia, Qiao Yang, Ying Wu, Dekang Zhu, Shun Chen, Mafeng Liu, Xinxin Zhao, Shaqiu Zhang, Xiaoyue Chen, Yunya Liu, Yanling Yu, Ling Zhang   +16 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Multifrequency Variability of Blazars 3C 279 and 3C 345 [PDF]

Symposium - International Astronomical Union, 1994
The multifrequency spectra of Blazars 3C 279 and 3C 345 are presented and their implications for theoretical models are discussed. The spectra resulted from two separate but complimentary observational programs; one a serendipitous discovery by CGRO that extended the spectrum up to GEV energies, while the other a program designed to investigate the ...
openaire   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source