Results 121 to 130 of about 1,553,287 (292)

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Nuevos aceros TWIP/TRIP en los automóviles del futuro

3C Tecnología, 2012
This paper aims to introduce the reader to a group of materials that promise to be relevant in the evolution of automotive structures, and probably change the way design elements resistant. It describes the most relevant properties.
Rafael Pla Ferrando, Samuel Sánchez Caballero, Miguel Ángel Sellés Cantó, José Enrique Crespo Amorós   +3 more
doaj  

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Estudio, análisis y clasificación de elastómeros termoplásticos

3C Tecnología, 2012
This study aims to collect, analyze and classify the different thermoplastic elastomersin order to carry out a review of art and be given sufficient information about this set of materials with characteristics based on reprocess ability and elasticity.
David Garcia Sanoguera, Santiago Ferrándiz Bou, Rafael Balart Gimeno, David Juárez Varón   +3 more
doaj  

Growth of 6H-SiC on CVD-Grown 3C-SiC Substrates

, 1989
Polytype control and crystal growth on 3C-SIC substrates have been investigated by using a sublimation growth technique. Single crystalline 3C-SiC(100) films (∼10μm thick) grown on Si (100) were used as substrates after removing Si by etching with a HF ...
Hiroyuki Matsunami, Woo Sik Yoo
core   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Metodología para el cálculo de la viscosidad empleando como caso práctico el reprocesado de ABS

3C Tecnología, 2012
This paper explains the methodology for calculating the viscosity, using as a case study the recycling of Acrylonitrile–Butadiene–Styrene (ABS). To simulate recycled ABS, virgin ABS was processed through 5 cycles, at extreme processing temperatures ...
Francisco Parres García, David Juarezz Varon, Miguel Ángel Sellés Cantó, Miguel Ángel Peydró Rasero   +3 more
doaj  

Comprehensive analysis of microtwins in the 3C-SiC films on Si(001) substrates

, 2001
Microtwins in the 3C-SiC films grown on Si(0 0 1) by atmosphere pressure chemical vapor deposition (APCVD) were investigated in detail using X-ray four-circle diffractometry.
Qu B, Yang H, Zheng XH,Chinese Acad Sci,Inst Semicond,R&D Ctr Optoelec Technol,POB 912,Beijing 100093,Peoples R China., Dai ZZ, Zheng XH, Wang YT, Liang JW, Han JY   +7 more
core  

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Multivalent Interactions Between the Picornavirus 3C(D) Main Protease and RNA Oligonucleotides Induce Liquid–Liquid Phase Separation

Viruses
The picornavirus 3CD protein is a precursor to the 3C main protease and the 3D RNA-dependent RNA polymerase. In addition to its functions in proteolytic processing of the virus polyprotein and cleavage of key host factors, the 3C domain interacts with ...
Somnath Mondal, Saumyak Mukherjee, Kevin E. W. Namitz, Neela H. Yennawar, David D. Boehr   +4 more
doaj   +1 more source