Results 141 to 150 of about 2,403,682 (282)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Faraday rotation and depolarization in the powerful DRAGNs 3C 34, 3C 228 and 3C 340 [PDF]
Monthly Notices of the Royal Astronomical Society, 1995 R. A. Johnson +2 more
openaire +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
New Observations of 3C 382, 3C 452 and 3C 465 at 2.7 and 5 GHz [PDF]
Monthly Notices of the Royal Astronomical Society, 1973 J. M. Riley, N. J. B. A. Branson
openaire +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
El conformado incremental como nueva técnica de prototipado rápido
3C Tecnología, 2012 Various industrial sectors (aerospace, automotive,) use forming processes nowadays to produce components of complex shapes from sheet metal. Traditional processes that use arrays are suitable for the production of large volumes of parts, but are not ...
Miguel Ángel Peydró Rasero +3 more
doaj
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Recuperación de Hips mediante sebs: Caracterización reológica y mecánica
3C Tecnología, 2013 The effect of reprocessing two mixtures: recycled high impact polystyrene (HIPS) with polybutadiene (PB); and HIPS with styrene-ethylene-butylenestyrene (SEBS) have been studied in this article. Our results show that tensile strength increases, while the
Miguel Ángel Peydró Rasero +3 more
doaj
The rotation axes of 3C 33, 3C 98, 3C 184.1, and 3C 218
The Astrophysical Journal, 1979 openaire +1 more source