Results 101 to 110 of about 5,662,897 (253)

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Near-field nano holographic tomography with chemical contrast exploiting low-dimensionality constraints

JPhys Photonics
X-ray absorption near-edge structure (XANES) spectroscopy is key to understanding functional materials. We present, to our knowledge, the first use of hard x-ray near-field holography (NFH) for three-dimensional (3D), spatially resolved XANES.
Johannes Gruen, Johannes Dora, Thea Engler, Martin Seyrich, Andreas Schropp, Jakob Soltau, Markus Osterhoff, Thomas L Sheppard, Tim Salditt, Christian G Schroer, Johannes Hagemann   +10 more
doaj   +1 more source

Aïoli, une plateforme d'annotation sémantique 3D pour la documentation collaborative d'objets patrimoniaux

, 2020
"Modéliser puis annoter un objet patrimonial en 3D à l’aide d’un simple smartphone, c’est ce que permet aujourd’hui le web service Aïoli développé au sein du laboratoire MAP ...."
Consortium 3D SHS Team
core  

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Residual Stress Distribution and Its Effect on Fatigue Crack Path of Laser Powder Bed Fusion Ti6Al4V Alloy

Aerospace
Residual stress (RS) in laser powder bed fusion (LPBF) additive manufactured structures can significantly affect mechanical performance, potentially leading to premature failure.
Wenbo Sun, Yu’e Ma, Peiyao Li, Weihong Zhang   +3 more
doaj   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Mixed-Mode Electro Optical Properties of Ge2Sb2Te5 [PDF]

, 2013
In this paper we present ongoing work on a novel alternative mode of operation of phase change materials, specifically Ge2Sb2Te5: mixed-mode electro-optical operation, which offers a new set of potential applications for this ...
Harish Bhaskaran (1357371), Wolfram H.P. Pernice (20194992), Peiman Hosseini (11852257), C. David Wright (3796741), G Rodriguez-Hernandez (21833195), YY Au (21840008)   +5 more
core   +2 more sources

Stable three-dimensional solitons in spin-orbit-coupled atomic-molecular condensates

Physical Review Research
We elaborate a mechanism for the creation of stable three-dimensional (3D) solitons in spin-orbit-coupled (SOC) atomic-molecular Bose-Einstein condensates, modeled by the mean-field equations with the quadratic three-wave interaction, characterized by ...
Chao Kong, Jinqing Li, Guihua Chen, Guilong Li, Zhaopin Chen, Haiming Deng, Boris A. Malomed, Yongyao Li   +7 more
doaj   +1 more source

Cette visualisation en 3D de poumons endommagés par Covid-19 permet de mieux comprendre le danger

, 2020
" Une vidéo en 3D montre les dommages aux poumons d'une personne atteinte du Covid-19. Diffusée par le Dr. Keith Mortman, qui travaille à l'hôpital universitaire de George-Washington, aux Etats-Unis, la vidéo a été produite en partenariat avec Surgical ...
Consortium 3D SHS Team
core