Results 41 to 50 of about 179,536 (231)
Journal of Rock Mechanics and Geotechnical EngineeringRock masses in high-elevation or cold regions are vulnerable to the combined effects of freeze-thaw (F-T) weathering and dynamic mixed-mode loading, posing a serious threaten to the safety and stability of geotechnical engineering.
Zhihui Cui +5 more
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Three-dimensional buoyancy-driven convection structures in thermohaline stratification
AIP Advances, 2016 We report on three-dimensional convection structures in thermohaline stratification with the high Rayleigh number RaT = 7 ⋅ 107, the diffusion ratio δ = 0.01 and various initial density stability ratios R = 0.5, 0.8, and 1.1.
Ye-Jun Gong, Ying-Ying Luo, Jie-Min Zhan
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Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
SoftwareXEvaluating the conditions for crack propagation under static and cyclic loads is critical for predicting the lifespan of engineering components, particularly in the energy and transport industries.
Abdalrhaman Koko, James Marrow
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Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Utilizing A Game Engine for Interactive 3D Topographic Data Visualization
ISPRS International Journal of Geo-Information, 2019 Developers have long used game engines for visualizing virtual worlds for players to explore. However, using real-world data in a game engine is always a challenging task, since most game engines have very little support for geospatial data.
Dany Laksono, Trias Aditya
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Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Electrical Coupling and Simulation of Monolithic 3D Logic Circuits and Static Random Access Memory
Micromachines, 2019 In order to simulate a circuit by applying various logic circuits and full chip using the HSPICE model, which can consider electrical coupling proposed in the previous research, it is investigated whether additional electrical coupling other than ...
Tae Jun Ahn +3 more
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