Results 71 to 80 of about 5,662,897 (253)
Development of a Finite Element Methodology for Modelling Mixed-Mode Delamination Growth [PDF]
, 2007 A critical failure mechanism for composite skin-stiffened structures in compression is separation of the skin and stiffener, which can be considered analogous to interlaminar cracking.
Degenhardt, Richard +4 more
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
L’archivage pérenne des modèles numériques 3D pour les SHS
, 2020 Ce document est la formalisation d’une étape de la réflexion consacrée à l'archivage des données 3D mené au sein du consortium 3D SHS en collaboration avec Huma-Num et le CINES.
Consortium 3D SHS Team
core
Delamination of Z-pinned carbon fibre reinforced laminates [PDF]
, 2005 The paper outlines the current status of mechanical testing, identification of failure mechanisms and data analysis related to delamination cracking in high performance laminates made via the prepreg/autoclave route, strengthened in the through ...
Cartié, Denis D. R. +2 more
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
An Investigation Study on Mode Mixing Separation in Empirical Mode Decomposition
IEEE Access, 2019 Mode mixing is a limitation of the empirical mode decomposition (EMD) method appropriate for physiological signal analysis. In 2008, boundary condition map presented by Rilling and Flandrin provided the efficiency of separating the two components of a ...
Han-Ping Huang +5 more
doaj +1 more source
Vocabulaire 3D - Lexique pour les Sciences Humaines et Sociales
, 2020 "Ce document est le résultat d’un effort continu pour permettre aux acteurs des SHS et ceux de la 3D d’interagir autour d’un vocabulaire commun. Ce lexique a pour but d’accompagner les différents livrables du consortium 3D.
Consortium 3D SHS Team
core
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
[Article] 3D digital recording of archaeological, architectural and artistic heritage
, 2020 3D DIGITAL RECORDING OF ARCHAEOLOGICAL, ARCHITECTURAL AND ARTISTIC HERITAGE
Consortium 3D SHS Team
core
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source