Results 131 to 140 of about 3,388,278 (296)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
, 2020 " CloudCompare is a 3D point cloud (and triangular mesh) processing software. It has been originally designed to perform comparison between two dense 3D points clouds (such as the ones acquired with a laser scanner) or between a point cloud and a ...
Consortium 3D SHS Team
core
3D pressure-corrected ballistic extrapolation of solar wind speed in the inner heliosphere
Journal of Space Weather and Space ClimateSolar wind parameters at different locations in the inner heliosphere can be estimated using various solar wind extrapolation methods. The simple ballistic method extrapolates solar wind parameters from the point of measurement to a chosen heliospheric ...
Timar Aniko +7 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
, 2021 Dans le cadre des missions du consortium 3D SHS, nous vous sollicitons pour proposer des actions à mener pour développer, évaluer, finaliser des outils et des méthodologies concernant l’usage de la 3D pour la recherche en SHS.
Consortium 3D SHS Team
core
LA TERZA DIMENSIONE IN ARCHEOLOGIA
Archeomatica, 2016 With the arrival of the “Digital Age” and new technologies, modern archeology started to deal with the concept of 3-Dimension. Educational text books on archaeological methodology still tend to classify, however, the third dimension primarily as a ...
Stefano Calò
doaj
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
, 2020 ". Access the real-time 3D development platform and workflows that professionals use to create immersive experiences across industries.Free for students. .
Consortium 3D SHS Team
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source