Results 161 to 170 of about 5,698,007 (273)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Organoids: Unveiling Insights with Volume Electron Microscopy [PDF]

BIO Web of Conferences
Beng Lu Thon, Racine Victor, Beghin Anne, Guerin-Bonne Isabelle   +3 more
doaj   +1 more source

Interactive Vision-Based 3D Augmented Reality System for In-Home Rehabilitation in Older Adults Following Total Joint Replacement: Cross-Sectional Survey of Patients and Service Providers. [PDF]

JMIR Aging
Salvia AC, Phadke S, Kunz M, Fakolade A.
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

3D-Mesenchymal stromal cells derived VASH2 alleviates oxidative stress-induced endothelial senescence by mediating α-tubulin detyrosination in systemic sclerosis. [PDF]

J Transl Med
Zhang Y, Shi Y, Liu S, Yan Y, Wang Z, Yang D, Wen X, Zhu Y, Zheng X, Chen Y, Liu S, Sun L.   +11 more
europepmc   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

3D-Assisted Scapular Fracture Fixation in a Polytraumatized Patient: A Case Report. [PDF]

J Orthop Case Rep
Dobrich J, Deegan MK, Gerber CD, Min KS.
europepmc   +1 more source

3D including 3D IC and 3D Packaging

Advancing Microelectronics Magazine, 2013
openaire   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Next-generation epidermal patches: Bridging 3D and multidimensional printing for biomedical and personal care innovations. [PDF]

Bioact Mater
El-Khordagui LK, El-Habashy SE, Simchi A, Tohamy HS, Focarete ML, Rea M, Di Lisa L, Barman SR, Nain A, Catanzano O, Boateng J, Dodda JM.   +11 more
europepmc   +1 more source