Results 131 to 140 of about 379,593 (353)

Expanding Hereditary Spastic Paraplegias Limits: Biallelic SPAST Variants in Cerebral Palsy Mimics

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegias (HSP) are rare neurodegenerative disorders marked by spasticity and lower limb weakness. The most common type, SPG4, is usually autosomal dominant and caused by SPAST gene variants, typically presenting as pure HSP.
Gregorio A. Nolasco   +18 more
wiley   +1 more source

Exosome Proteomics of SOD1D90A Mutation Suggest Early Disease Mechanisms, and FN1 as a Biomarker

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Amyotrophic lateral sclerosis (ALS) is a neuromuscular disease. Super oxide dismutase 1 (SOD1) gene mutations cause ALS, and the D90A mutation is associated with primarily upper motor neuron (UMN) loss. Objective Our goal is to reveal the early cellular events in ALS pathology and identify potential pharmacokinetic biomarkers, using well ...
Mukesh Gautam   +6 more
wiley   +1 more source

Decreased Serum 5‐HT: Clinical Correlates and Regulatory Role in NMJ of MG

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although 5‐Hydroxytryptamine (5‐HT) indirectly stimulates muscle contraction and participates in regulating Acetylcholine receptor (AChR) cluster homeostasis in cellular, animal, and clinical studies, evidence regarding its potential to modulate muscle contraction in myasthenia gravis (MG) remains limited.
Xinru Shen   +18 more
wiley   +1 more source

THE TRANSFORMATIVE IMPACT OF ADVANCED GRAPHICS TECHNOLOGIES AND COMPUTER-GENERATED IMAGERY IN CIVIL ENGINEERING

open access: yesJournal of Industrial Design and Engineering Graphics
The present study explores how modern graphics technology and computer-generated imagery (CGI) are revolutionizing the field of civil engineering. With an emphasis on 3D modelling, the study investigates how virtual reality (VR), augmented reality (AR),
Ioana-Roxana BACIU   +3 more
doaj   +2 more sources

Frailty Exacerbates Disability in Progressive Multiple Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background To evaluate frailty in severe progressive multiple sclerosis (PMS) and to investigate the underlying mechanisms. Methods This prospective, cross‐sectional, multicenter study enrolled a late severe PMS group requiring skilled nursing (n = 53) and an age, sex, and disease duration‐matched control PMS group (n = 53).
Taylor R. Wicks   +10 more
wiley   +1 more source

A multi-smart agent-based training environment for enhancing 3D graphics production and design thinking skills among elementary computer teachers

open access: yesFrontiers in Education
This study introduces a multi-smart agent-based training environment aimed at enhancing the production of 3D graphics and fostering design-thinking skills among primary-stage computer teachers.
Shaymaa E. Sorour   +3 more
doaj   +1 more source

3D-CT vascular setting protocol using computer graphics for the evaluation of maxillofacial lesions [PDF]

open access: diamond, 2001
Marcelo de Gusmão Paraíso Cavalcanti   +2 more
openalex   +1 more source

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