Results 61 to 70 of about 379,593 (353)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Efficient Measurement of Shape Dissimilarity between 3D Models Using Z-Buffer and Surface Roving Method

EURASIP Journal on Advances in Signal Processing, 2002
Estimation of the shape dissimilarity between 3D models is a very important problem in both computer vision and graphics for 3D surface reconstruction, modeling, matching, and compression.
In Kyu Park, Kyoung Mu Lee, Sang Uk Lee
doaj   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

3D Graphics with Spreadsheets

Spreadsheets in Education, 2008
In the article, the formulas for orthographic parallel projection of 3D bodies on computer screen are derived using secondary school vector algebra. The spreadsheet implementation is demonstrated in six applications that project bodies with increasing ...
Jan Benacka
doaj  

An experimental study to test a 3D laser Scanner for body measurement and 3D virtual garment design in Fashion education [PDF]

, 2005
Artists, scientists, anthropometrists and tailors have accurately measured the human body with traditional tools, such as tape measures, callipers and accumulated visceral experience for centuries. Due to the progressive acceleration in the quality of 3D
Taylor, Andrew, Unver, Ertu
core  

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

3D-DESIGN OF THE TOURIST MAPS

InterCarto. InterGIS, 2015
Modern map designe is heavily influenced by the achievements in computer graphics software development. 3D symbols are widely used now in different maps. Such symbols are used very often in the design of various tourist maps.
L. L. Karpovich, L. A. Ushakova
doaj   +1 more source

Using 3D computer graphics for perception [PDF]

Proceedings of the 4th symposium on Applied perception in graphics and visualization, 2007
Everyday life requires us to recognize faces under transient changes in pose, expression and lighting conditions. Despite this, humans are adept at recognizing familiar faces. In this study, we focused on determining the types of information human observers use to recognize faces across variations in viewpoint. Of specific interest was whether holistic
Schwaninger, A., Schumacher, S., Wallraven, C., Bülthoff, H.   +3 more
openaire   +2 more sources