Results 81 to 90 of about 379,593 (353)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
3D geometry. A proposal to integrate computer graphics in descriptive geometry
Revista de Expresión Gráfica en la Edificación, 2016 El presente artículo se centra en el estudio de la integración de los programas de informática gráfica en la didáctica de la Geometría Descriptiva y los nuevos planteamientos que pueden aportar a esta disciplina.
Javier Pita Andreu
doaj +1 more source
HOLOGRAPHICS: Combining Holograms with Interactive Computer Graphics [PDF]
, 2006 Among all imaging techniques that have been invented throughout the last decades, computer graphics is one of the most successful tools today. Many areas in science, entertainment, education, and engineering would be unimaginable without the aid of 2D or
Bimber, Oliver (Prof. Dr.)
core
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Study of 3D Technologies for Web
Digital Presentation and Preservation of Cultural and Scientific Heritage, 2019 This paper presents solutions for objectives and presentation related to 3D technology exploration and three-dimensional web visualization, implementation of approaches for 3D reconstruction of museum exhibits, creation of models for three-dimensional ...
Pavel Hristov, Emiliyan Petkov
doaj +1 more source
Shadow Techniques on Contemporary Hardware and Their Comparison [PDF]
, 2014 Tato práce se zabývá technikami tvorby stínů ve 3D počítačové grafice. V práci jsou srovnány dvě základní techniky - stínové mapy a stínová tělesa. Následně je navržena nová technika, kombinující obě předchozí.This master's project focuses on basic ...
Tóth, Michal
core
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Three-dimensional imaging and scanning: Current and future applications for pathology
Journal of Pathology Informatics, 2017 Imaging is vital for the assessment of physiologic and phenotypic details. In the past, biomedical imaging was heavily reliant on analog, low-throughput methods, which would produce two-dimensional images.
Navid Farahani +7 more
doaj +1 more source
Procedural Vegetation Generation [PDF]
, 2013 Tato bakalářská práce se zabývá procedurálním generováním vegetace za pomocí L-systémů. Představuje procedurální generování jako prostředek pro tvorbu modelů rostlin.
Zuzaňák, Ondřej
core
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source