Results 171 to 180 of about 1,556,426 (318)

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Embryotoxicity and mixture effects of legacy PFAS in a human iPSC-based 3D model. [PDF]

Cell Biol Toxicol
Treschow AF, Martiny E, Gutierrez CT, Niklas AA, Scholze M, Vinggaard AM, Valente MJ.   +6 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Scaling deep learning for material imaging with a pseudo 3D model for domain transfer. [PDF]

Nat Commun
Tang K, Armstrong RT, Mostaghimi P, Niu Y, Meyer Q, Zhao C, Finegan DP, Popeil M, Singh K, Menke H, Dimou AP, Bultreys T, Mascini A, Knackstedt M, Da Wang Y.   +14 more
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

In Vitro 3D Model of Human Endometrial Stromal and Trophoblast Cells: Techniques for an Optimized Formation and Cryopreservation of Spheroids. [PDF]

Methods Protoc
Muthuraj K, Scheliga I, Baston-Buest DM, Bender-Liebenthron J, Kruessel JS, Bielfeld AP.   +5 more
europepmc   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

The Fracture Mechanism of Impact-Resistant Bionic 3D Model Structures Inspired by Composite Structure of Mantis Shrimp Appendage. [PDF]

Biomimetics (Basel)
Yang X, Meng M, Meng X, Huang A, Shao C, Wang Y, Jin H.   +6 more
europepmc   +1 more source

Böhmisches Gewölbe, Fläche 4. Ordnung, 3D-Darstellung

BÖHMISCHES GEWÖLBE, FLÄCHE 4. ORDNUNG, 3D-DARSTELLUNG Böhmisches Gewölbe, Fläche 4. Ordnung, 3D-Darstellung ( -
Alpers, Ulrich, Brill
core  

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source