Results 191 to 200 of about 1,556,426 (318)

Heterotypic 3D Model of Breast Cancer Based on Tumor, Stromal and Endothelial Cells: Cytokines Interaction in the Tumor Microenvironment. [PDF]

Cells
Leonteva A, Kazakova A, Berezutskaya E, Ilyina A, Sergeevichev D, Vladimirov S, Bogachek M, Vakhrushev I, Makarevich P, Richter V, Nushtaeva A.   +10 more
europepmc   +1 more source

Structure and Function of a 3D Gingivae-biofilm Interface Model

Objectives: Oral diseases such as gingivitis and periodontitis arise through a dysregulated immune response to microbial challenge. Here we combined a 3D model of gingival epithelium with a complex biofilm, to represent the periodontal pocket to study ...
Ramage, Gordon, Rajendran, Ranjith, Bradshaw, David, Butcher, John, Brown, Jason, Culshaw, Shauna, Khan, Shaz   +6 more
core  

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Building the blood-brain barrier: a scalable self-assembling 3D model of the brain microvasculature under unidirectional flow. [PDF]

Fluids Barriers CNS
Admiraal J, Emeh PO, Bokkers M, de Ruiter SPM, Olivier T, Queiroz K, Burton TP, Wevers NR.   +7 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

A 3D model to evaluate cell chemotaxis within a heterogenic tumor microenvironment.

Lab Chip
Rodrigues DB, Cruz-Moreira D, Gasperini L, Jarnalo M, Horta R, Reis RL, Pirraco RP.   +6 more
europepmc   +1 more source

A fully iPS-cell-derived 3D model of the human blood-brain barrier for exploring neurovascular disease mechanisms and therapeutic interventions. [PDF]

Nat Neurosci
González-Gallego J, Todorov-Völgyi K, Müller SA, Antesberger S, Todorov MI, Malik R, Grimalt-Mirada R, Gonçalves CC, Schifferer M, Kislinger G, Weisheit I, Lindner B, Crusius D, Kroeger J, Borri M, Erturk A, Nelson M, Misgeld T, Lichtenthaler SF, Dichgans M, Paquet D.   +20 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Assessment of the ligamentous stress distribution in the pathomechanics of the boutonniere deformity through a computational 3D model. [PDF]

J Orthop Surg Res
Solitro GF, Echenique DB, Gonzalez MH, Amirouche F.   +3 more
europepmc   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source