Results 91 to 100 of about 22,841,869 (341)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

METRIC EVALUATION PIPELINE FOR 3D MODELING OF URBAN SCENES

, 2017
. Publicly available benchmark data and metric evaluation approaches have been instrumental in enabling research to advance state of the art methods for remote sensing applications in urban 3D modeling.
Marc Bosch, A. Leichtman, D. Chilcott, H. Goldberg, M. Brown   +4 more
semanticscholar   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Basin analysis palaeo‐landscape modelling: Testing the critical controls using experimental design constrained by a real 3D geological model, Gippsland Basin, Australia [PDF]

, 2022
Xuemei Yang, Gregory Smith, Ritu Gupta
openalex   +1 more source

Next generation 3D pharmacophore modeling

WIREs Computational Molecular Science, 2020
3D pharmacophore models are three‐dimensional ensembles of chemically defined interactions of a ligand in its bioactive conformation. They represent an elegant way to decipher chemically encoded ligand information and have therefore become a valuable ...
David Schaller, Dora Šribar, Theresa Noonan, Lihua Deng, T. Nguyen, Szymon Pach, David Machalz, M. Bermudez, Gerhard Wolber   +8 more
semanticscholar   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Security and surveillance application in 3D modeling of a smart city: Kirkuk city as a case study

Open Engineering
Smart cities use information and communications technology to offer a wide range of applications targeted for improving the quality of life and perfecting urban services.
Sadiqe Noor Emad, Jasim Oday Zakariya, Al-Bakri Maythm   +2 more
doaj   +1 more source

3D Face Modeling based on 3D Morphable Shape Model

The Journal of the Korea Contents Association, 2008
Since 3D face can be rotated freely in 3D space and illumination effects can be modeled properly, 3D face modeling Is more precise and realistic in face pose, illumination, and expression than 2D face modeling. Thus, 3D modeling is necessitated much in face recognition, game, avatar, and etc. In this paper, we propose a 3D face modeling method based on
Yong-Suk Jang, Boo-Gyoun Kim, Seong-Won Cho, Sun-Tae Chung   +3 more
openaire   +2 more sources

TriSI: A Distinctive Local Surface Descriptor for 3D Modeling and Object Recognition

GRAPP/IVAPP, 2016
Local surface description is a critical stage for surface matching. This paper presents a highly distinctive local surface descriptor, namely TriSI. From a keypoint, we first construct a unique and repeatable local reference frame (LRF) using all the ...
Yulan Guo, Ferdous Sohel, Bennamoun, Min Lu, Jianwei Wan   +4 more
semanticscholar   +1 more source