Results 111 to 120 of about 398,436 (318)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
The Self-Referenced DLR 3D-Modeler
, 2009 In the context of 3-D scene modeling, this work aims at the accurate estimation of the pose of a close-range 3-D modeling device, in real-time and passively from its own images.
Hirzinger, Gerd +14 more
core +1 more source
Plane-based registration of construction laser scans with 3D/4D building models [PDF]
, 2012 With the development of building information modelling (BIM) and terrestrial laser scanning (TLS) in the architecture, engineering, construction and facility management (AEC/FM) industry, the registration of site laser scans and project 3D (BIM) models ...
Bosché, Frédéric, Frédéric Bosché
core +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Мінеральні ресурси УкраїниCurrently, the development of gas and gas-condensate reservoirs with bottom water remains insufficiently effective, while the phenomenon of coning is a fundamental problem in petroleum engineering. To develop methods for slowing down or preventing bottom
S. V. Matkivskyi, I. I. Chudyk
doaj +1 more source
Separation of line drawings based on split faces for 3D object reconstruction
, 2014 © 2014 IEEE. Reconstructing 3D objects from single line drawings is often desirable in computer vision and graphics applications. If the line drawing of a complex 3D object is decomposed into primitives of simple shape, the object can be easily ...
core +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Laser scanning and 3d modeling of historical heritage
, 2012 Laser scanning and 3d modeling of historical ...
CATUOGNO, RAFFAELE
core
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source