Results 121 to 130 of about 398,436 (318)
Uso produttivo e riproduttivo del 3D modeling
, 2018 In un saggio pubblicato nel 1922 da László Moholy-Nagy dal titolo Produktion-Reproduktion, si so- steneva che il compito dell’artista dovrebbe essere quel- lo di usare in modo “produttivo” e non solo “riproduttivo” tutte le tecnologie e i media ...
Quici, Fabio, Quici Fabio
core
Depth Representation Method by Color Tone for 3D Graphics Modeler [PDF]
, 2011 3D computer graphics modeling software that is meant to be operated in a 2D environment comes equipped with a mouse and a 2D display, it is difficult to use these tools to edit 3D mesh objects.
Chisa Morishita +3 more
core +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
, 2006 Use of automation in construction is increasing at a rapid pace because it provides ways of dealing with skilled labour shortages, and of improving safety, quality and productivity.
Bosche, Frederic Nicolas, Haas, Carl T.
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Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Universal attraction force-inspired freeform surface modeling for 3D sketching
, 2006 This paper presents a novel freeform surface modeling method to construct a freeform surface from 3D sketch. The approach is inspired by Newton’s universal attraction force law to construct a surface model from rough boundary curves and unorganized ...
Wright, David +3 more
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Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source