Results 81 to 90 of about 2,162,733 (357)

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Modelling and 3D Printing of Crankshaft [PDF]

International Journal of Trend in Scientific Research and Development, 2019
Power from the burnt gases in the combustion chamber is delivered to the crankshaft through the piston, piston pin and connecting rod. The crankshaft changes reciprocating motion of the piston in cylinder to the rotary motion of the flywheel. Crankshaft is designed for multi cylinder engine and its 3D model is created using modeling software CATIA ...
T. Venkata Ramana, Sagam Kunta Subhash, Sangem Devendra Kumar | Vanga Balakrishna   +2 more
openaire   +1 more source

Large-Scale Urban 3D Geological Modeling Based on Multi-Method Coupling Under Multi-Source Heterogeneous Data Conditions

Applied Sciences
The development and utilization of urban underground space represents a crucial strategy for achieving sustainable urban development. Three-dimensional (3D) geological models provide a data foundation and technical support for research in urban planning ...
Jixiang Zhu, Xiaoyuan Zhou, Lizhong Zhang   +2 more
doaj   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

The influence of mining activities on the Church of St. Cross in Bytom-Miechowice

Reports on Geodesy and Geoinformatics, 2018
The paper presents an analysis of the influence of multiannual coal exploitation on the church situated in Bytom–Miechowice. The objects has been monitored for many years by classic measurement methods as well as by the laser scanner.
Lipecki Tomasz, Ligarska Hanna, Zawadzka Małgorzata   +2 more
doaj   +1 more source

A coiled‐coil domain triggers oligomerization of MmpL10, the mycobacterial transporter of trehalose polyphleate precursor

FEBS Letters, EarlyView.
Most MmpLs transport lipids and glycolipids of the complex mycomembrane of mycobacteria. This study shows that MmpL10 from Mycobacterium smegmatis, the transporter of the trehalose polyphosphate precursor, harbors a coiled‐coil‐like extension. Biochemical and electron microscopy studies demonstrate that the coiled‐coil enables MmpL10 to trimerize.
Julie Couston, Jérôme Feuillard, Aurélie Ancelin, Joséphine Lai‐Kee‐Him, Konstantin Brodolin, Christian Chalut, Pontus Gourdon, Mickaël Blaise   +7 more
wiley   +1 more source

Local recurrences after laparoscopic resections for renal parenchymal cancer

Андрология и генитальная хирургия, 2018
Introduction. Renal cancer constitutes 2–3 % of all tumors of the human body. Annually worldwide renal cancer morbidity increases by 2 %, about 90 % of cases are localized in the parenchyma.
Yu. G. Alyaev, L. M. Rapoport, E. S. Sirota, E. A. Bezrukov, A. V. Kondrashina   +4 more
doaj   +1 more source

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Learning while Competing -- 3D Modeling & Design

, 2019
The e-Yantra project at IIT Bombay conducts an online competition, e-Yantra Robotics Competition (eYRC) which uses a Project Based Learning (PBL) methodology to train students to implement a robotics project in a step-by-step manner over a five-month ...
Arya, Kavi, Bessariya, Rucmenya, Karia, Kalind, Lala, Krishna   +3 more
core   +1 more source

A hierarchical anti-Hebbian network model for the formation of spatial cells in three-dimensional space. [PDF]

, 2018
Three-dimensional (3D) spatial cells in the mammalian hippocampal formation are believed to support the existence of 3D cognitive maps. Modeling studies are crucial to comprehend the neural principles governing the formation of these maps, yet to date ...
Chakravarthy, Srinivasa, Soman, Karthik, Yartsev, Michael   +2 more
core   +3 more sources