Results 81 to 90 of about 299,387 (267)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Assessing the Impact of AI-Enhanced Diagnostic Tools on the Treatment Planning of Orthodontic Cases: An RCT

Journal of Pharmacy and Bioallied Sciences
BackgroundOrthodontic treatment planning involves the precise assessment of dental and skeletal anomalies, which can be facilitated by AI-enhanced diagnostic tools. Materials and MethodsA total of 100 orthodontic cases were included in this RCT. Patients
Mohammed Imad, Ribin Mohammed, Kumar D Chetan, Thomas Pallavi A, Saini Ruchi   +4 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

3D-GPT: Procedural 3D Modeling with Large Language Models

2025 International Conference on 3D Vision (3DV)
Project page: https://chuny1.github.io/3DGPT/3dgpt ...
Sun, Chunyi, Han, Junlin, Deng, Weijian, Wang, Xinlong, Qin, Zishan, Gould, Stephen   +5 more
openaire   +2 more sources

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Implementation of inverted classroom methodology in 3D modeling course [PDF]

FME Transactions, 2019
More than one decade 3D modeling in SolidWorks is taught at the Faculty of Mechanical Engineering at the University of Belgrade (Serbia). As every new skill that has to be mastered, SolidWorks software package demands well-tailored teaching methodology ...
Joksimović Aleksandra D., Veg Emil A., Simonović Vojislav D., Regodić Mladen M., Šiniković Goran B., Gubeljak Nenad   +5 more
doaj  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

IDENTIFIKASI PATAHAN SEISMO-TEKTONIK JAYAPURA BERDASARKAN PEMODELAN INVERSI 3D DATA GRAVITASI

JGE
Pada awal tahun 2023 wilayah Kota Jayapura dan sekitarnya mengalami gempabumi dengan seismisitas yang tinggi dan terjadi terus menerus. Gempabumi tersebut termasuk ‘Black Swan Earthquakes’ karena di luar prediksi para ahli; langka terjadi; dan sumber ...
Bangkit Sudrajad, Tatang Sutarman, Ego Srivajawaty Sinaga, Hubertus Ngaderman   +3 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source