Results 101 to 110 of about 8,252,764 (291)

In Situ Photo‑Crosslinked Functional Bilayer Hydrogel Modulates Local Microenvironment and Remyelination After Optic Nerve Injury

Advanced Science, EarlyView.
A blue‐light‐crosslinked bilayer hydrogel was developed for local optic nerve repair. The adhesive GM‐Odex outer layer seals and anchors the lesion, while the non‐adhesive GM‐imid inner layer releases MPDA‐Cle without obstructing CSF flow. This system modulates oxidative and inflammatory microenvironments, supports oligodendrocyte differentiation and ...
Tonghe Pan, Yate Huang, Junhao Zhang, Shudong Tian, Zhixing Li, Xuanwen Li, Yanchen Zhang, Dongmei Wang, Sihao Ye, Ming Jin, Neng Ling, Wentao Yan, Kaihui Nan, Wencan Wu   +13 more
wiley   +1 more source

High‐Conductivity Active Interface Layer for Active Lithium Reservoir in Micro‐Silicon‐Based All‐Solid‐State Batteries

Advanced Science, EarlyView.
A self‐generated Li–Si alloy interface transforms carbon‐free micro‐silicon into a kinetically accelerated and mechanically resilient anode for sulfide‐based all‐solid‐state batteries. Serving simultaneously as an active lithium reservoir and conductive interface, the alloy layer compensates lithium loss while accommodating volume changes, enabling 89 ...
Ziqing Wang, Xinxin Zhu, Ruichen Zhu, Wendi Dou, Qian Zhang, Jun Lu, Junxiu Wu   +6 more
wiley   +1 more source

A Fish MDA5 Integrates Canonical RIG‐I and MDA5 Ligand Recognition

Advanced Science, EarlyView.
These results show that the large yellow croaker lacks RIG‐I, yet its MDA5 senses both 5′ppp‐dsRNA and long dsRNA. A flexible RNA‐capping loop in the MDA5 C‐terminal domain enables two ligand‐binding modes. This dual recognition signals through MAVS–STING–TBK1/IRF3 and induces type I interferons, revealing unexpected plasticity in vertebrate antiviral ...
Wenxing Li, Yuan Feng, Huazhi Chen, Jiamei Liu, Álvaro Fernández Montero, Jiangtao Gao, Jingqun Ao, Xinhua Chen   +7 more
wiley   +1 more source

3D Consortium: Creation, scientific use and archiving of 3D data for Humanities and Social Sciences

, 2020
"Dariah annual Event 23- 24 mai 2018. The 3D Consortium, accredited in 2014 by Huma-Num, brings together eleven partners working in the field of archaeology and cultural heritage and who already have experience of using 3D technologies and producing 3D ...
Consortium 3D SHS Team
core  

To Be or Not to Be Eutectic: Anomalous Glass Forming Ability Governed by Melt Structural Complexity

Advanced Science, EarlyView.
Challenging the eutectic rule, congruently melting Ti–Cu alloys show greater glass‐forming ability than their eutectic counterparts. This arises from the congruent melt's structural complexity: higher cluster diversity and stronger inter‐cluster correlations from entropy–enthalpy competition.
Wei Chen, Xuerui Wei, Chengzhe Wang, Zhichao Lu, Fan Zhang, Yan Huang, Yibo Zhang, Liang Wang, Saichao Cao, Chunyin Zhou, Ke Yang, Zhendong Fu, Jinkui Zhao, Dongbai Sun, Fanqiang Meng, Zhou Zhou, Xun‐li Wang, Weihua Wang, Dong Ma   +18 more
wiley   +1 more source

Rational Surface Engineering Reduces Advanced Glycation End‐Product Adsorption and Improves Implant Integration

Advanced Science, EarlyView.
Targeted surface chemical modification prevents the accumulation of advanced glycation end products (AGEs) on implant surfaces, attenuates inflammation and fibrosis, effectively restores angiogenic activity, and improves osseointegration under diabetic conditions.
Thien Ngoc Le, Wenhao Chen, Tengxiao Huang, Tien Thanh Nguyen, Markos Negash Alemie, Xuan Duy Do, Giles Best, Jordan Li, Jitraporn Vongsvivut, Vi‐Khanh Truong, Weiwei Li, Yunpeng Zhao, Richard Bright, Krasimir Vasilev   +13 more
wiley   +1 more source

RUNX1‐Mediated Hypoxic Signaling Impairs Myogenesis and Promotes Fibrosis in Myopathies

Advanced Science, EarlyView.
Myofiber overgrowth was associated with reduced blood flow and a potential hypoxic state in broiler breast muscle, accompanied by increased RUNX1 expression. Elevated RUNX1 impaired myogenic regeneration, promoted fibrosis, and disrupted the signaling niche required for efficient muscle repair, contributing to pathological degeneration in Wooden Breast
Liang Zhao, Taijiang Hou, Lin Zhang, Feng Gao, Tong Xing   +4 more
wiley   +1 more source

PHGDH‐Mediated Serine Metabolism in Nucleus Pulposus Cells Is a Potential Therapeutic Target for Intervertebral Disc Degeneration

Advanced Science, EarlyView.
When nucleus pulposus cells senesce, PHGDH decreases, reducing serine synthesis and glutathione, impairing antioxidant capacity. The intermediate α‐KG also drops, lowering JMJD3 demethylase activity, increasing H3K27me3 at the Rap1b promoter, and reducing Rap1b expression, whose down‐regulation in turn activates mTORC1 and suppresses autophagy ...
Hao‐Wei Xu, Sheng‐Jie Chang, Xiao‐Wei Liu, Shu‐Bao Zhang, Ying‐Jie Wang, Shan‐Jin Wang   +5 more
wiley   +1 more source

Unveiling the complex morphologies of sessile droplets on heterogeneous surfaces

Communications Physics
Droplets exhibiting a myriad of shapes on surfaces are ubiquitous in both nature and industrial applications. In high-resolution manufacturing processes, e.g., semiconductor chips, precise control over wetting shapes is crucial for production accuracy ...
Yanchen Wu, Hongmin Zhang, Fei Wang, Britta Nestler   +3 more
doaj   +1 more source

Building Lightweight 3D Indoor Models from Point Clouds with Enhanced Scene Understanding

Remote Sensing
Indoor scenes often contain complex layouts and interactions between objects, making 3D modeling of point clouds inherently difficult. In this paper, we design a divide-and-conquer modeling method considering the structural differences between indoor ...
Minglei Li, Mingfan Li, Min Li, Leheng Xu   +3 more
doaj   +1 more source