Results 91 to 100 of about 3,226,598 (309)

[Article] 3D digital recording of archaeological, architectural and artistic heritage

open access: yes, 2020
3D DIGITAL RECORDING OF ARCHAEOLOGICAL, ARCHITECTURAL AND ARTISTIC HERITAGE
Consortium 3D SHS Team
core  

Improving Artistic Design With KFDeformNet: Single-Frame Three-Dimensional Cartoon Face Recovery

open access: yesIEEE Access
We propose KFDeformNet, a novel framework for enhancing 3D cartoon face recovery from single-frame inputs. Existing methods struggle to capture the fine details and exaggerated characteristics common in artistic cartoon designs.
Tong Sun, Xiaohui Wang, Yichen Qi
doaj   +1 more source

Ligand-Based Pharmacophore Modeling Using Novel 3D Pharmacophore Signatures

open access: yesMolecules, 2018
Pharmacophore modeling is a widely used strategy for finding new hit molecules. Since not all protein targets have available 3D structures, ligand-based approaches are still useful. Currently, there are just a few free ligand-based pharmacophore modeling
Alina Kutlushina   +3 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

open access: yesFEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise   +5 more
wiley   +1 more source

Réaliser un projet de modèles numériques 3D pour le patrimoine. Guide de rédaction d'un cahier des charges

open access: yes, 2020
"Dans le cadre des activités du Consortium 3D de la TGIR Huma-Num, de nombreuses rencontres ont eu lieu réunissant des spécialistes aux profils divers (historiens, archéologues, informaticiens, architectes, ingénieurs 3D, archivistes …etc.) afin de ...
Consortium 3D SHS Team
core  

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

open access: yesFEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux   +7 more
wiley   +1 more source

Pre-training molecular graph representation with 3D geometry

open access: yes, 2022
Molecular graph representation learning is a fundamental problem in modern drug and material discovery. Molecular graphs are typically modeled by their 2D topological structures, but it has been recently discovered that 3D geometric information plays a ...
Liu, Shengchao   +5 more
core  

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