Results 191 to 200 of about 90,374 (275)

Single Cell and Spatially Resolved Transcriptome and Immune Repertoire of Mouse Thymus During Aging Reveal Immunological Heterogeneity and Direction of Thymic Selection Pressure

open access: yesAging Cell, Volume 25, Issue 8, August 2026.
A systemic single‐cell and spatially‐resolved transcriptomics and TCR sequencing analysis across the aging thymus dissects the molecular underpinnings of T cell subset dynamics. The study highlights the shifting proportions and transcriptomic profiles of T cell subsets during aging.
Jialing Fang   +14 more
wiley   +1 more source

Multi‐Omics Integration Reveals That SN‐011 Targets JUNB to Upregulate ADGRE5 and Restore Vascular Endothelial Cell Communication in Ischemic Stroke

open access: yesChemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
Ischemic stroke (IS) remains a leading cause of disability with limited therapeutic targets. Using multi‐omics integration, we identified ADGRE5 as a protective gene significantly downregulated in venous endothelial cells (vECs) during IS. JUNB acts as a key upstream transcription factor that negatively regulates ADGRE5 expression.
XiangLing Ou, ZunKe Gong
wiley   +1 more source

Integrating Artificial Intelligence Into Drug Discovery From Medicinal Plants: Current Applications and Infrastructural Challenges

open access: yesChemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
This review presents a systems‐oriented roadmap for integrating artificial intelligence into medicinal plant drug discovery to overcome persistent bottlenecks like extract complexity. It highlights that advancing toward reproducible therapeutics requires making phytochemical datasets AI‐ready via rigorous harmonization and phyto‐centric foundational ...
Amit Gangwal   +5 more
wiley   +1 more source

Novel Bio-Inspired Physics-Based Learning and Evolutionary Guidance for Dynamic Multi-Objective Cold Chain Routings. [PDF]

open access: yesBiomimetics (Basel)
He T   +12 more
europepmc   +1 more source

Structure‐Aware Unsupervised Transmission Corridor Structure Extraction From 3DEP Lidar Using Graph Attention Embeddings and Reinforcement‐Learned DBSCAN

open access: yesTransactions in GIS, Volume 30, Issue 5, August 2026.
ABSTRACT Transmission corridors are critical components of power delivery infrastructure, and their large‐area monitoring increasingly relies on national‐scale airborne lidar programs. This study presents an unsupervised, scalable framework for extracting transmission corridor structures (including conductors and supporting towers) from U.S. Geological
Nanzhou Hu   +4 more
wiley   +1 more source

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