Results 101 to 110 of about 9,013,010 (294)

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Integrated Multi‐Omics Reveals Cellular States and Microenvironmental Remodeling in Coexisting DCIS and IDC

Advanced Science, EarlyView.
Coexisting DCIS and IDC samples are profiled using spatial transcriptomics, single‐cell RNA sequencing, and single‐cell DNA sequencing. Integrative multi‐omics analysis reveals distinct malignant epithelial and microenvironmental features between DCIS and IDC, which are further validated using Xenium and multiplex immunohistochemistry.
Ning Zhang, Tong Wan, Siyue Zhang, Yunzhen Jiang, Peng Su, Jixin Liu, Zhitong Chen, Jie Hao, Haoyu Wang, Bing Chen, Wenjing Zhao, Lijuan Wang, Tao Xing, Qihuang Zhang, Ulf Schmitz, Zhiyong Ding, Nicola Crosetto, Bingqiang Liu, Qifeng Yang   +18 more
wiley   +1 more source

POMA-3D: The Point Map Way to 3D Scene Understanding

CoRR
In this paper, we introduce POMA-3D, the first self-supervised 3D representation model learned from point maps. Point maps encode explicit 3D coordinates on a structured 2D grid, preserving global 3D geometry while remaining compatible with the input format of 2D foundation models.
Ye Mao, Weixun Luo, Ranran Huang 0004, Junpeng Jing, Krystian Mikolajczyk   +4 more
openaire   +2 more sources

Single‐Cell Transcriptomic Profiling Identifies B Cell‐Intrinsic Dysregulation of Sphingolipid Biosynthesis and Could Be Improved by Inhibiting UGCG in Primary Immune Thrombocytopenia

Advanced Science, EarlyView.
This study generates the single‐cell atlas of pathogenic B‐cell subset Bc‐5 in ITP. It identifies RUNX3 as a key survival regulator and uncovers sphingolipid‐driven metabolic reprogramming, validating UGCG inhibition as a therapeutic candidate and building a valuable resource for ITP mechanistic and therapeutic exploration.
Dongmei Luo, Yanxia Zhan, Lili Ji, Pengcheng Xu, Pu Chen, Hao Pang, Yunan Ling, Fanli Hua, Xibing Zhuang, Hao Chen, Yunfeng Cheng   +10 more
wiley   +1 more source

LLM-Supervised Point Cloud Processing: From Unsupervised 3D Scene-Graph Generation to Interactive Scene Manipulation [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences
We demonstrate an end-to-end pipeline for 3D scene understanding which integrates unsupervised graph-based point cloud segmentation with LLM-enabled spatial reasoning and editing.
F. Poux, F. Poux, A. Key
doaj   +1 more source

VLA-3D: A Dataset for 3D Semantic Scene Understanding and Navigation

CoRR
Accepted and presented at the 1st Workshop on Semantic Reasoning and Goal Understanding in Robotics (SemRob), Robotics Science and Systems Conference (RSS 2024)
Haochen Zhang 0001, Nader Zantout, Pujith Kachana, Zongyuan Wu, Ji Zhang 0003, Wenshan Wang   +5 more
openaire   +2 more sources

An Expertise Transfer Framework For Autonomous Surgical Assistance

Advanced Science, EarlyView.
This study introduces an expertise transfer framework for procedure‐spanning autonomous surgical assistance. By emulating expert logic through hierarchical perception, attention modeling, and knowledge graph‐based decision‐making, the system provides near‐expert surgical view assistance.
Yuan Gao, Guangdi Chu, Wei Jiao, Yuchuan Zhong, Hang Yuan, Chengjun Li, Jinhua Li, Shuxin Wang, Bo Guan, Jianchang Zhao, Lizhi Pan, Haitao Niu, Jianmin Li   +12 more
wiley   +1 more source

Integrated high-precision real scene 3D modeling of karst cave landscape based on laser scanning and photogrammetry

Scientific Reports
In recent years, the application of real scene 3D technology has become widespread in urban planning and cultural heritage protection. However, there has been relatively little attention paid to the construction of real scene 3D models for special ...
Congyuan Zhang, Jianping Chen, Ping Li, Sipeng Han, Jie Xu   +4 more
doaj   +1 more source

SceneReasoner: Decoupled Spatial Tokenization for Indoor Large-Scene Understanding with LLMs [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences
Most existing 3D vision-language models focus on object-level or single-room understanding and perform poorly in large-scale, multi-room indoor environments where task-relevant objects constitute only a small fraction of the total point cloud. When multi-
B. Shi, S. Tang, X. Li, W. Wang, L. Xie, B. Zhou, B. Zhou   +6 more
doaj   +1 more source

Embodied intelligence for 3D understanding: A survey on 3D Scene question answering

Information Fusion
3D Scene Question Answering (3D SQA) represents an interdisciplinary task that integrates 3D visual perception and natural language processing, empowering intelligent agents to comprehend and interact with complex 3D environments. Recent advances in large multimodal modelling have driven the creation of diverse datasets and spurred the development of ...
Zechuan Li, Hongshan Yu, Yihao Ding, Yan Li 0186, Yong He 0012, Naveed Akhtar   +5 more
openaire   +2 more sources