Results 71 to 80 of about 4,975,139 (352)

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

T1 Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ± 
Sarah J. Wright, Scotty G. McKay, Jean Ramos Bou, Fen Bao, Vivian B. Truong, Chenyang Li, Li Jiang, Anza B. Memon, E. Mark Haacke, Yulin Ge, Yongsheng Chen   +10 more
wiley   +1 more source

Precision scans of the pixel cell response of double sided 3D pixel detectors to pion and x-ray beams [PDF]

, 2011
hree-dimensional (3D) silicon sensors offer potential advantages over standard planar sensors for radiation hardness in future high energy physics experiments and reduced charge-sharing for X-ray applications, but may introduce inefficiencies due to the ...
Akiba, K., Gimenez, E N, Pellegrini, G., D Pennicard, R Plackett, Marchal, J., Bates, R, K Akiba, V V Gligorov, N Tartoni, John, M., C Fleta, Tlustos, L, Lozano, M., K J S Sawhney, Parkes, C.; id_orcid, Nicol, M, Alianelli, L., R Bates, Pennicard, D., Campbell, M, Alianelli, L, D Maneuski, Fleta, C., Pellegrini, G, Gimenez, N., M Gersabeck, Dumps, R., J Buytaert, E N Gimenez, M John, Buytaert, J, Lozano, M, Marchal, J, Pennicard, D, Gallas, A, Plackett, R, M Nicol, L Eklund, Stewart, G, C Parkes, Rodrigues, E, Gallas, A., Dumps, R, Gligorov, V., L Tlustos, M Crossley, Bates, R., Fleta, C, Parkes, C, Mac Raighne, A, Plackett, R., J Marchal, Nicol, M., Rodrigues, E., Gimenez, E.N., Akiba, K, Stewart, G., L Alianelli, Tlustos, L., Maneuski, D., Gersabeck, M, Collins, P., John, M, Campbell, M., M van Beuzekom, Sawhney, K J S, Tartoni, N, Crossley, M, Crossley, M., M Campbell, Llopart, X., Gersabeck, M., G Stewart, Tartoni, N., P Collins, G Pellegrini, Collins, P, A Gallas, van Beuzekom, M., E Rodrigues, Parkes, C., X Llopart, R Dumps, Eklund, L, Sawhney, K.J.S., Llopart, X, MacRaighne, A., Mac Raighne, A., Gligorov, V.V., Maneuski, D, A Mac Raighne, Eklund, L., Gligorov, V V, M Lozano, Sawhney, S., van Beuzekom, M, Buytaert, J.   +97 more
core   +1 more source

Gravity‐Dependent Modulation of Downbeat Nystagmus: Insights From Velocity‐Storage Dysfunction

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Downbeat nystagmus varies with head position, a phenomenon termed gravity‐dependent modulation. We aimed to clarify its mechanism using a velocity‐storage model. Methods In 10 patients with downbeat nystagmus due to cerebellar disorders, we recorded eye movements at different pitch‐ and roll‐axis head positions.
Ji‐Hyung Park, Eun‐Hyuk Choi, Jorge Otero‐Millan, David S. Zee, Jeong‐Yoon Choi, Ji‐Soo Kim   +5 more
wiley   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

[Article] 3D digital recording of archaeological, architectural and artistic heritage

, 2020
3D DIGITAL RECORDING OF ARCHAEOLOGICAL, ARCHITECTURAL AND ARTISTIC HERITAGE
Consortium 3D SHS Team
core  

Poste en photogrammétrie et modélisation 3D ( LabEx Archimede/CFEETK)

, 2021
"Appel à candidatures du LabEx Archimede et de la Fondation Universitaire Hiérolexique (Université Paul Valéry – Montpellier 3) pour un CDD d’Ingénieur-e d’études en photogrammétrie et modélisation 3D auprès de l’USR 3172 du CNRS - CFEETK, à Karnak....
Consortium 3D SHS Team
core  

Simulation adsorption characteristics of fullerene dispersions

Физико-химические аспекты изучения кластеров, наноструктур и наноматериалов
Mechanisms of action of fullerenes on biological systems are not yet fully understood. Fullerenes can be modified to increase their efficiency and safety in medicine and drug delivery. Various ligands can be attached to them increasing their selectivity
O.A. Dyudyun, A.A. Komarova, K.S. Elbekyan, G.D. Dyudyun   +3 more
doaj   +1 more source

A Two‐Stage Plasma Biomarker Algorithm Reduces Amyloid PET Use and the p‐Tau217 Gray Zone

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma p‐Tau217 leaves 30%–50% of patients in an indeterminate “gray zone” often requiring Aβ‐PET. We developed GRAD (Gatekeeper‐Reflex for Alzheimer's Disease), a two‐stage Aβ‐positivity prediction model to improve classification while reserving Aβ‐PET for residual uncertainty.
Harthik Parankusham, Casey Vanderlip, Colin Birkenbihl, Eashwar Krishna, Chizobam Ugboaja, Andrew E. Budson, Brandon Frank, for the Alzheimer's Disease Neuroimaging Initiative   +7 more
wiley   +1 more source

3D Consortium: Creation, scientific use and archiving of 3D data for Humanities and Social Sciences

, 2020
"Dariah annual Event 23- 24 mai 2018. The 3D Consortium, accredited in 2014 by Huma-Num, brings together eleven partners working in the field of archaeology and cultural heritage and who already have experience of using 3D technologies and producing 3D ...
Consortium 3D SHS Team
core