Results 31 to 40 of about 263,020 (247)

From Strategy to Impact: How Young People Create Social and Environmental Change Through Youth Service Programs

Youth
Young people have a desire to meaningfully contribute to their communities and create lasting impact. While youth service programs aim to support this goal, research often emphasizes youth development over social and environmental outcomes.
Ilona Dougherty, Heather Lawford, Valentina Castillo Cifuentes, Amelia Clarke, Odeeth Lara-Morales, Aleksandra Spasevski   +5 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Study of Uplink Interference in UMTS Network: ASIACELL Company, Iraq

Kurdistan Journal of Applied Research, 2020
Universal Mobile Telecommunications System (UMTS), is the third generation (3G) of mobile communication which is based on the wideband code division multiple access (W-CDMA) radio access to provide bandwidth and spectral efficiency.
Bakhtiar Ali Karim, Bzhar Rahaman Othman
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Harnessing Vehicle-to-Vehicle Communications for 3G Downloads on the Move

International Journal of Distributed Sensor Networks, 2014
This paper studies the problem of 3G downloads in vehicles on the move. Although the 3G brings larger coverage and instant access to data transfer, it may also incur high cost. We observe that many applications of vehicular 3G users can actually tolerate
Yanmin Zhu, Qinghua Chen, Chao Chen
doaj   +1 more source

Contamination of Wheat Cultivated in Various Regions of Poland during 2017 and 2018 Agricultural Seasons with Selected Trichothecenes and Their Modified Forms

Toxins, 2019
Cross-interaction of antibodies within the immunoaffinity columns used in this study facilitated the simultaneous determination of nivalenol (NIV), deoxynivalenol (DON), their glucoside derivatives (NIV-3G, DON-3G), and 3-acetyl-deoxynivalenol (3-AcDON ...
Marcin Bryła, Edyta Ksieniewicz-Woźniak, Tomoya Yoshinari, Agnieszka Waśkiewicz, Krystyna Szymczyk   +4 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Bulanık Mantık Tabanlı – Uzaktan Erişimli Sera Otomasyonu

Düzce Üniversitesi Bilim ve Teknoloji Dergisi, 2016
Bu çalışmada endüstriyel denetim sistemlerinde yaygın olarak kullanılan PLC (Programlanabilir Mantık Denetleyicisi) ile bir sera sistemi kontrolü gerçekleştirilmiştir.
Mustafa Ayan, Ramazan Şenol
doaj  

Prognostic value, immune signature and molecular mechanisms of the APOBEC family members APOBEC1, APOBEC3A, APOBEC3G and APOBEC3H in pancreatic adenocarcinoma

Frontiers in Molecular Biosciences, 2022
Background: Increasing evidence supports that the APOBEC family is associated with development of a variety of cancers. However, the function of APOBEC1/3A/3G/3H in pancreatic adenocarcinoma (PAAD) is still unclear.Methods: Comprehensive bioinformatic ...
Yunjie Duan, Yongxing Du, Zongting Gu, Xiaohao Zheng, Chengfeng Wang   +4 more
doaj   +1 more source